Navigation Links
Genetic risk factors play role in autoantibody-negative rheumatoid arthritis

During the past few years, several new genetic risk factors for rheumatoid arthritis (RA) have been identified. The majority of genetic risk factors identified so far have been associated with autoantibody-positive RA, which affects about two-thirds of RA patients, but distinguishing this variant from autoantibody-negative RA, which is less destructive, is considered increasingly important.

A new study led by Diane van der Woude of Leiden University Medical Center in The Netherlands examined 148 twin pairs in which one twin had RA. Participants were tested for antibodies known as anti-citrullinated protein antibodies (ACPAs), which are used because of their specificity and predictive value and for HLA SE (human leukocyte antigen shared epitope) alleles, the most important genetic risk factor for RA. The study was published in the April issue of Arthritis & Rheumatism (

The findings show that ACPA-positive and ACPA-negative RA are associated with different genetic and environmental risk factors, and may constitute distinct entities with different disease mechanisms. The results also showed that the heritability the variation in disease susceptibility that can be explained by genetic factors - was about 66 percent for both ACPA-positive and ACPA-negative RA.

The HLA SE alleles contributed 11 percent to the total genetic variance of RA, 18 percent to the genetic variance of ACPA-positive RA, and only about 2 percent to the genetic variance of ACPA-negative RA. In the past, HLA genes were estimated to contribute 37 percent to the overall inherited risk of RA.

Several new genetic risk factors for RA have recently been identified, but like the HLA SE alleles, they are predominantly associated with ACPA-positive RA. This may be because studies typically include mainly ACPA-positive patients, since most RA patients fall into this group. The authors suggest that new studies that incorporate more ACPA-negative patients will show that these risk factors also predispose individuals to this form of the disease.

The known risk factors for ACPA-negative disease do not confer as high a risk of developing RA as the HLA SE alleles. In light of the finding of the similar heritability of ACPA-positive and ACPA-negative RA, the authors conclude: "This means that genetic predisposition also plays an important role in the pathogenesis of ACPA-negative RA, for which most individual genetic risk factors remain to be identified."


Contact: Sean Wagner

Related medicine news :

1. Gene Network Sciences Names Departing Merck Head of Genetics Eric Schadt as Co-Chair of Scientific Advisory Board
2. Interleukin Genetics Grants LABEC Pharma a License for Sales and Distribution of Its Heart Health Genetic Test
3. Genetic Finding May Lead to Male Contraceptive
4. Genetic link uncovered in disparate colon cancer death
5. Interleukin Genetics Receives NYSE Amex Staff Determination, Requests Oral Hearing Before the Listing Qualifications Panel
6. Roberta A. Pagon Receives Lifetime Award in Genetics from March of Dimes
7. Genetic changes outside nuclear DNA suspected to trigger more than half of all cancers
8. Researchers Suspect Genetic Link to COPD
9. Genetics Should Decide Warfarin Dose, Study Reiterates
10. Improved Genetic Test Product Empowers Individuals to Better Understand Their Unique Nutritional Needs
11. 23andMe Launches Parkinsons Disease Genetics Initiative
Post Your Comments:
(Date:11/27/2015)... ... , ... Indosoft Inc., developer and distributor of the world-class ... (Long Term Support) into its Q-Suite 5.10 product line. , Making the change ... version of Asterisk that will receive not only security fixes, but feature and ...
(Date:11/26/2015)... ... November 26, 2015 , ... ... eReferral system for diagnostic imaging in the Waterloo region. Using the Ocean Platform, ... Medicine tests directly from their electronic medical record (EMR) without the need for ...
(Date:11/26/2015)... ... , ... Jobs in hospital medical laboratories and in the imaging field lead ... Aureus Medical Group . These fields, as well as travel nursing, ... healthcare jobs through the company’s website, , The leading healthcare staffing ...
(Date:11/26/2015)... ... 26, 2015 , ... Pixel Film Studios brings Final Cut ... Vintage. This newly styled ProTrailer pack comes with 30 all-new vintage-inspired designs, with ... users limitless opportunities to stylize and create designs quickly and easily, all within ...
(Date:11/25/2015)... ... November 25, 2015 , ... Additional breast ... found on mammography, according to a study published online in the journal Radiology. ... on mammography may necessitate a change in treatment. , Breast MRI is the ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... DUBLIN , November 26, 2015 /PRNewswire/ ... the addition of the "Radioimmunoassay Market ... User (Hospital, Pharmaceutical Industry, Academics, Clinical Diagnostic ... - Global Forecast to 2020" report ... ) has announced the addition of the ...
(Date:11/25/2015)... , Nov. 25, 2015 ... addition of the "Global Brain Monitoring ... offering. --> ) has ... Brain Monitoring Devices Market 2015-2019" report ... and Markets ( ) has announced ...
(Date:11/25/2015)... 2015  Amgen (NASDAQ: AMGN ) today announced ... the United States (U.S.) Food ... candidate to Humira ® (adalimumab). Amgen believes this ... the FDA and represents Amgen,s first BLA submission using ... , M.D., executive vice president of Research and Development ...
Breaking Medicine Technology: