Navigation Links
Genetic risk factors play role in autoantibody-negative rheumatoid arthritis
Date:4/7/2009

During the past few years, several new genetic risk factors for rheumatoid arthritis (RA) have been identified. The majority of genetic risk factors identified so far have been associated with autoantibody-positive RA, which affects about two-thirds of RA patients, but distinguishing this variant from autoantibody-negative RA, which is less destructive, is considered increasingly important.

A new study led by Diane van der Woude of Leiden University Medical Center in The Netherlands examined 148 twin pairs in which one twin had RA. Participants were tested for antibodies known as anti-citrullinated protein antibodies (ACPAs), which are used because of their specificity and predictive value and for HLA SE (human leukocyte antigen shared epitope) alleles, the most important genetic risk factor for RA. The study was published in the April issue of Arthritis & Rheumatism (http://www3.interscience.wiley.com/journal/76509746/home).

The findings show that ACPA-positive and ACPA-negative RA are associated with different genetic and environmental risk factors, and may constitute distinct entities with different disease mechanisms. The results also showed that the heritability the variation in disease susceptibility that can be explained by genetic factors - was about 66 percent for both ACPA-positive and ACPA-negative RA.

The HLA SE alleles contributed 11 percent to the total genetic variance of RA, 18 percent to the genetic variance of ACPA-positive RA, and only about 2 percent to the genetic variance of ACPA-negative RA. In the past, HLA genes were estimated to contribute 37 percent to the overall inherited risk of RA.

Several new genetic risk factors for RA have recently been identified, but like the HLA SE alleles, they are predominantly associated with ACPA-positive RA. This may be because studies typically include mainly ACPA-positive patients, since most RA patients fall into this group. The authors suggest that new studies that incorporate more ACPA-negative patients will show that these risk factors also predispose individuals to this form of the disease.

The known risk factors for ACPA-negative disease do not confer as high a risk of developing RA as the HLA SE alleles. In light of the finding of the similar heritability of ACPA-positive and ACPA-negative RA, the authors conclude: "This means that genetic predisposition also plays an important role in the pathogenesis of ACPA-negative RA, for which most individual genetic risk factors remain to be identified."


'/>"/>

Contact: Sean Wagner
medicalnews@bos.blackwellpublishing.com
781-388-8550
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. Gene Network Sciences Names Departing Merck Head of Genetics Eric Schadt as Co-Chair of Scientific Advisory Board
2. Interleukin Genetics Grants LABEC Pharma a License for Sales and Distribution of Its Heart Health Genetic Test
3. Genetic Finding May Lead to Male Contraceptive
4. Genetic link uncovered in disparate colon cancer death
5. Interleukin Genetics Receives NYSE Amex Staff Determination, Requests Oral Hearing Before the Listing Qualifications Panel
6. Roberta A. Pagon Receives Lifetime Award in Genetics from March of Dimes
7. Genetic changes outside nuclear DNA suspected to trigger more than half of all cancers
8. Researchers Suspect Genetic Link to COPD
9. Genetics Should Decide Warfarin Dose, Study Reiterates
10. Improved Genetic Test Product Empowers Individuals to Better Understand Their Unique Nutritional Needs
11. 23andMe Launches Parkinsons Disease Genetics Initiative
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2017)... ... March 29, 2017 , ... The Wall ... referral to new patients from Burnaby, BC. Patients in need of experienced orthodontics, ... services, can see the esteemed team at Wall Centre Dental. Drs. Parviz Roshan, ...
(Date:3/29/2017)... ANN ARBOR, Mich. (PRWEB) , ... ... ... Global Retailer and Manufacturer Alliance (GRMA) is growing as it continues developing ... the dietary supplement industry. The organization, which plans to publish the first ...
(Date:3/29/2017)... , ... March 29, 2017 , ... ... with wearing oral braces. "The rubber bands used in conjunction with my braces ... I decided to design a way to prevent this problem." The O.B.S. was ...
(Date:3/29/2017)... ... 2017 , ... Hamlin Dental Group, multi-location dental office in North Hollywood ... lasers are safe and effective options, and can be used alone or in conjunction ... quality of care. , Dr. Hamid Reza of Hamlin Dental Group offers other treatments ...
(Date:3/29/2017)... ... ... AvePoint , the Microsoft Cloud expert, is pleased to announce the official ... Riverfront Plaza, 901 East Byrd Street. AvePoint is celebrating with a ribbon-cutting ceremony on ... of Richmond Levar M. Stoney. , Founded in 2001, AvePoint employs more than 1,400 ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... NEW YORK , March 29, 2017 FinancialBuzz.com ... Data published in ... medical cannabis market will reach a value of USD 55.8 billion by ... the United States and a more open approach ... Arkansas , Florida , North Dakota ...
(Date:3/28/2017)... , March 28, 2017 The global emerging ... CAGR of 13.45% from 2016 to 2023 and reach ... Description Cancer is a chronic disease and is ... the cancer diagnostics market. This report is focused on ... The market growth is propelled due to factors such ...
(Date:3/28/2017)... , March 28, 2017  Rosen Law Firm, ... of a class action lawsuit on behalf of purchasers ... KTOV ) pursuant and/or traceable to Kitov,s initial public ... and/or on the open market from November 20, 2015 ... Period"). The lawsuit seeks to recover damages for Kitov ...
Breaking Medicine Technology: