Navigation Links
Genetic regulator opens new avenues to AIDS, immune system research
Date:7/1/2010

CORVALLIS, Ore. Researchers at Oregon State University and the California Institute of Technology have discovered that a genetic regulator which is critical to many life functions also plays a key role in the formation of "T cells," a type of white blood cell that's important in immune function.

The discovery, to be announced Friday in the journal Science, suggests that some types of immune function might be influenced by manipulation of this genetic regulator. This could be a target for drug development, and could open the door to new immune system-based therapies for everything from diseases of T cells, such as HIV/AIDS, to autoimmune disorders and allergies.

Other aspects of the research could be of interest to scientists trying to re-program cells to perform different functions, which is the basis of stem cell research.

The genetic regulator, or transcription factor, is called Ctip2, and it's also known as Bcl11b. It's a protein that controls gene "expression," or what aspects of a cell's genetic code will be turned on and which will be left silent. Discovered at OSU in 2000, Ctip2 has in recent years been found to be a master regulator of gene expression, controlling tissue formation in organs as diverse as tooth enamel, brain cells, skin, and T cells.

"Ctip2 is so important to various life functions that laboratory mice lacking this gene die within a few hours after birth," said Mark Leid, a professor and assistant dean in the OSU College of Pharmacy. "Ctip2 is not expressed in every cell, but plays essential roles in several different organs. The new finding about its relationship to early events in T cell formation may be of substantial interest to immunologists and clinicians alike."

T cells are important players in what's called the "adaptive" immune system, or the ability of an organism to mount an attack against a new invader, fight it off and then provide full or partial immunity to it in the fut
'/>"/>

Contact: Mark Leid
mark.leid@oregonstate.edu
541-737-5809
Oregon State University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Medco Acquires Leading Genetics Healthcare Company, DNA Direct
2. Genetic Variants in Depressed People Raise Suicide Risk
3. St. Jude and Washington University team to unravel genetic basis of childhood cancers
4. Discovery of epigenetic memory during breast cancer
5. Genetic Test May Someday Help Spot Breast Cancer
6. Advances in Genetic Understanding and Treatment Protocols Lead to Significant Progress in Leukemia and Myeloproliferative Disorders
7. Wistar-led research team discovers genetic pattern that indicates early-stage lung cancer
8. New License Agreement with University of Colorado Gives Viral Genetics, Inc., Right to Develop Cancer Therapies
9. U-M Study Reveals Surprising Lack of Genetic Diversity in the Most Widely Used Human Embryonic Stem Cell Lines
10. Chicago Cancer Genome Project studies genetics of 1,000 tumors
11. Adding a genetic supertool
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... 26, 2014 “Every three months the trends ... A-line sweetheart evening dress will be one of the hottest ... of Yunx.co.uk says. Today, the company releases 26 A-line sweetheart ... to 80% off. , “We are trying our best ... with our latest designs. Along with affordable prices, we provide ...
(Date:12/25/2014)... December 25, 2014 Recently, BellasDress ... on all its wedding dresses. BellasDress has chosen their ... for gift choices for the holiday season. , ... pick suitable wedding gowns here at discount prices. The ... experience at its website. , “All our ...
(Date:12/25/2014)... 25, 2014 Recently, LunaDress.co.uk has updated its blog ... related accessories. Now, all of the models at LunaDress.co.uk come with ... groom lifts the wedding veil can turn out to be a ... A wedding veil can always bring surprise to a wedding. On ... how to choose veils for a big day . , ...
(Date:12/25/2014)... 24, 2014 (HealthDay News) -- Among early stage breast ... than half of one percent will eventually develop leukemia ... reveals. The finding comes from a review of ... and 2007, and it suggests that the risk for ... experts had previously thought. "The frequency of bone ...
(Date:12/25/2014)... SmileStix ” was featured on NewsWatch as part of its ... on the iOS, Android, and Windows markets. Andrew Tropeano, a ... review and shared with viewers how this is an application ... goes, “A picture says a thousand words.” It’s true. There ... image, because each picture holds a unique and special meaning. ...
Breaking Medicine News(10 mins):Health News:BellasDress.com’s Christmas Sale: Trendy Wedding Dresses With Big Discounts 2Health News:LunaDress Provides Professional Tips On Shopping Wedding And Prom Dresses 2Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 2Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 3Health News:An Application to Create Custom Stickers was Featured on NewsWatch Television on December 19, 2014 2
... blood transfusion services for major hospitals throughout Washington ... provider of mobile productivity and management software, announced ... solution has been deployed by the Puget Sound ... access to wireless data and applications as they ...
... collection; simplifies UDS reportingTAMPA, Fla., March 24 ... integrated electronic health records and community health ... (FQHC) nationwide, Sage today announced that Family Health ... HealthLinc, formerly Hilltop Community Health Center, have selected ...
... Steps to Increase Participation in the School Breakfast ... L. Zahorchak today ate breakfast with 3rd graders ... breakfast programs and announce steps the department is ... who start the day with a healthy breakfast ...
... Veteran to Lead ItCOSTA MESA, Calif., March 24 ... it has hired Army Reserve officer Kirk Harrington, a ... as head of its newly-established warfighter division. Harrington is ... by the United States Department of State as a ...
... Cellegy Common Stock Expected to be Approximately 1: 9.929060BOYERTOWN, ... Board: CLGY) today announced that the stockholders of both ... merger of the two companies at stockholder meetings held ... subject to customary closing conditions, is expected to close ...
... March 24 Avidas(TM) Pharmaceuticals, a privately held, ... women,s health, today announced the launch of Scalacort(TM) ... in one patient convenience kit.Scalacort DK includes Scalacort ... in a clear fragrance-free base. Scalacort relieves itching ...
Cached Medicine News:Health News:NetMotion Wireless Boosts Mobile Productivity for Puget Sound Blood Center 2Health News:NetMotion Wireless Boosts Mobile Productivity for Puget Sound Blood Center 3Health News:NetMotion Wireless Boosts Mobile Productivity for Puget Sound Blood Center 4Health News:Community Health Centers Select Sage Intergy CHC Community Health Management System 2Health News:Community Health Centers Select Sage Intergy CHC Community Health Management System 3Health News:Community Health Centers Select Sage Intergy CHC Community Health Management System 4Health News:Community Health Centers Select Sage Intergy CHC Community Health Management System 5Health News:Community Health Centers Select Sage Intergy CHC Community Health Management System 6Health News:PA Education Secretary Emphasizes Importance of Breakfast for Student Performance 2Health News:Oxygen Biotherapeutics, Inc. Establishes Warfighter Division 2Health News:Oxygen Biotherapeutics, Inc. Establishes Warfighter Division 3Health News:Cellegy and Adamis Stockholders Approve Merger Transaction and Related Proposals 2Health News:Cellegy and Adamis Stockholders Approve Merger Transaction and Related Proposals 3Health News:Avidas(TM) Pharmaceuticals Introduces Scalacort(TM) DK Which Offers Three Scalp Solutions in One Patient Convenience Kit 2Health News:Avidas(TM) Pharmaceuticals Introduces Scalacort(TM) DK Which Offers Three Scalp Solutions in One Patient Convenience Kit 3
(Date:12/24/2014)... Mexico , Dec. 24, 2014  Novastem, ... of its first patient in its study for ... the American Stroke Association, ischemic strokes account for ... to enroll qualified patients in the study, entitled ... Administration of Allogeneic Mesenchymal Stem Cells and Intrathecal ...
(Date:12/24/2014)... PRINCETON, N.J. , Dec. 24, 2014 /PRNewswire/ ... Company), a late-stage biopharmaceutical company developing products that ... inflammation, oncology and biodefense, announced today that on ... registered public offering. The Company raised ... offering and intends to use the net proceeds ...
(Date:12/24/2014)... , December 24, 2014 ... at an average rate of 8.1%. The US has ... knee and spine surgeries are the common orthopedic procedures ... have a lower penetration. Increased number of product recalls ... Non-metallic orthopedic devices have gained popularity in the industry ...
Breaking Medicine Technology:Novastem Treats First Patient Using Stemedica's Mesenchymal and Neural Stem Cell Combination Therapy for Ischemic Stroke 2Novastem Treats First Patient Using Stemedica's Mesenchymal and Neural Stem Cell Combination Therapy for Ischemic Stroke 3Novastem Treats First Patient Using Stemedica's Mesenchymal and Neural Stem Cell Combination Therapy for Ischemic Stroke 4Soligenix Announces Closing of Public Offering of Units 2Soligenix Announces Closing of Public Offering of Units 3Use of Composites in Orthopedic Industry to Reach $596 Million by 2020 2Use of Composites in Orthopedic Industry to Reach $596 Million by 2020 3
... AURORA, Ohio , June 25 ... medical repair parts for hospital equipment, has been honored ... by Inside Business Magazine.  Now in its 13th year, ... industry,s greatest accomplishments by honoring local companies for their ...
... Soligenix, Inc. (OTC Bulletin Board: SNGX) (Soligenix ... the publication of an article in the June ... protection from mucosal and systemic ricin intoxication by intradermal ... ricin toxin. The article was authored by the Company,s ...
Cached Medicine Technology:PartsSource Wins 2010 Manny Award for Workplace Environment 2Soligenix Announces Publication of Positive Data Describing Protection from Mucosal and Systemic Ricin Intoxication by Intradermal RiVax™ Administration 2Soligenix Announces Publication of Positive Data Describing Protection from Mucosal and Systemic Ricin Intoxication by Intradermal RiVax™ Administration 3Soligenix Announces Publication of Positive Data Describing Protection from Mucosal and Systemic Ricin Intoxication by Intradermal RiVax™ Administration 4Soligenix Announces Publication of Positive Data Describing Protection from Mucosal and Systemic Ricin Intoxication by Intradermal RiVax™ Administration 5Soligenix Announces Publication of Positive Data Describing Protection from Mucosal and Systemic Ricin Intoxication by Intradermal RiVax™ Administration 6Soligenix Announces Publication of Positive Data Describing Protection from Mucosal and Systemic Ricin Intoxication by Intradermal RiVax™ Administration 7
Toothed pituitary rongeur. Straight....
Micro cup pituitary forceps, semi-malleable shafts....
Teardrop dissector. 90, 5 mm....
Papavero-caspar specula for trans-sphenoidal hypophysectomy....
Medicine Products: