Navigation Links
Genetic predictor of breast cancer response to chemotherapy
Date:5/11/2012

Chemotherapy is a major first line defense against breast cancer. However a patient's response is often variable and unpredictable. A study published in BioMed Central's open access journal BMC Medical Genomics shows that 'gene expression signatures' for TOP2A and β-tubulin can be used to predict the outcome of chemotherapy.

The goal of personalized medicine in cancer treatment is to target therapy to the characteristics of the individual tumor. For example Herceptin treatment is of most benefit to patients whose cancer is driven by HER2 and antiestrogens benefit patients whose breast cancer is hormonally driven. Gene signatures are increasingly available for different cancer types and can be used to predict patient prognosis.

Researchers from McMaster University, in association with the Juravinski Hospital and Cancer Center, analyzed the expression of the enzyme TOP2A (DNA topoisomerase) and β-tubulin, which are the targets of commonly used chemotherapy drugs (anthracycline and taxane) in hundreds of breast tumors. Combining the results from the tumor samples analyses allowed the researchers to build gene expression 'signatures' that measure the susceptibility of tumor cells to chemotherapy.

Both of the 'signatures' were separately able to predict which patients achieved a complete response (where invasive or metastatic cancer could no longer be detected) and together the two indices together were even more accurate at predicting response to chemotherapy.

Prof John Hassell, who led this study, commented, " Our results clearly demonstrate the practicality of using gene expression to personalize chemotherapy treatment for breast cancer patients. Identifying patients who will not benefit from a specific treatment means that they can be moved to a different treatment plan, and the earlier appropriate treatment is started the more likely it is that the patients will benefit from it."


'/>"/>
Contact: Dr. Hilary Glover
hilary.glover@biomedcentral.com
44-020-319-22370
BioMed Central
Source:Eurekalert

Page: 1

Related medicine news :

1. Advanced genetic screening method may speed vaccine development
2. Genetic abnormalities in benign or malignant tissues predict relapse of prostate cancer
3. Some women may be genetically predisposed to smoking-related hot flashes
4. Genetically modified T cell therapy shown to be safe, lasting in decade-long study of HIV patients
5. Moffitt researcher awarded GE grant to develop tool to detect breast cancer metastasis genetic risks
6. Research Gets Closer to Genetic Roots of Glaucoma
7. Genetic variants, tobacco exposure and lung cancer risk
8. Study of half siblings provides genetic clues to autism
9. Certain Genetic Regions May Be Tied to Osteoporosis
10. Head, Body Lice Are Genetically Very Similar
11. 2 genetic deletions in human genome linked to the development of aggressive prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2017)... ... January 23, 2017 , ... "ProRandom is a set of camera tools that allow video ... in Final Cut Pro X," said Christina Austin - CEO of Pixel Film Studios. ... of text with video footage. ProRandom works by using a virtual camera to create ...
(Date:1/23/2017)... ... January 23, 2017 , ... ... Society of Anesthesiologists® (ASA®), the Foundation for Anesthesia Education and Research (FAER), ... (AAOS) and the Cigna Foundation, encourages proposals supporting high quality research using ...
(Date:1/23/2017)... ... ... a story of love and redemption, hope and uncertainty as a girl makes her way ... at the Mill” is the creation of published author, Lois Kulp, who was born in ... County on Crow Hill. The inn, the mill and "Post Yokel" are within ...
(Date:1/23/2017)... , ... January 23, 2017 ... ... (SNP) has launched online education programs and resources at seafoodnutrition.org/programs and seafoodnutrition.org/resources ... benefits of a seafood-rich diet. These resources have been developed for use ...
(Date:1/23/2017)... ... ... “Some Infallible Characteristics of Christ”: a fascinating and entrancing novel exploring the gifts ... published author, Rev. Dr. Robert W. Thomas, the third of seven siblings. He was ... a pastor for over fifteen years. He is a graduate of N.C. College of ...
Breaking Medicine News(10 mins):
(Date:1/23/2017)... janvier 2017  ResMed (NYSE : RMD), BMC (Pékin, Chine) ... annoncé aujourd,hui qu,ils se sont mis d,accord sur le ... parties. BMC et 3B seront autorisés à vendre leurs ... ResMed, et ResMed effectuera le paiement de la décision ... litige de Floride entre les deux parties. Le règlement ...
(Date:1/23/2017)... 2017 NeuroVive Pharmaceutical AB (Nasdaq Stockholm: ... preclinical collaboration agreement with the Children,s Hospital of ... M.D., a US key opinion leader in the mitochondrial medicine ... ... from NeuroVive,s research program, NVP015, in certain experimental disease models. ...
(Date:1/22/2017)... DAVOS, Switzerland and ABU DHABI , ... leaders from the US ... , Hospital of the Future , at ... in the hospital of the future will be driven by big data and ... better," according to the panel of experts that discussed the ,Hospital of the ...
Breaking Medicine Technology: