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Genetic pathway can slow spread of ovarian cancer
Date:6/17/2014

inning to understand how this pathway might work in cancer and this work shows that it may act in completely different ways depending on the type of cancer. It also shows that these genes might be switched on in cancer but don't function properly."

The research team, involving University of Adelaide Professor Martin K. Oehler, Director of Gynecological Oncology at the Royal Adelaide Hospital, believes a mutation in this genetic pathway could promote the spread of ovarian cancer in patients.

"The laboratory tests have been conclusive that the intact gene prevents the spread of ovarian cancer. If we're able to better understand what's preventing these genes from functioning normally, this could be of significant interest for further research," Professor Oehler says.

"Ovarian cancer is the most lethal gynecological cancer world wide, and a better understanding of the molecular mechanisms responsible for its origin and progression are warranted to improve patient survival."

Associate Professor Grtzner says this research is an example of how basic science comparing species as different as platypus and humans can make significant contributions to the understanding of human disease.


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Contact: Associate Professor Frank Grützner, University of Adelaide
frank.grutzner@adelaide.edu.au
61-883-134-812
University of Adelaide
Source:Eurekalert

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