Navigation Links
Genetic pathway can slow spread of ovarian cancer
Date:6/17/2014

University of Adelaide research into the origins of ovarian cancer has led to the discovery of a genetic pathway that could slow the spread of the cancer.

The discovery is in part due to research into the genetics of humans' most distant mammalian relative, the platypus.

In a paper published today in the journal PLOS ONE, researchers characterize a genetic pathway involving piRNA genes that is turned on in ovarian cancer.

"This pathway is important for the development of the ovaries in drosophila flies but little is known about its role in the mammalian ovary," says lead author Associate Professor Frank Grtzner, Genetics Lecturer and ARC Research Fellow with the University of Adelaide's Robinson Research Institute and the School of Molecular and Biomedical Science.

"We previously found that these genes are active in cells supporting oocyte (egg cell) development in platypus, mice and humans, just like in flies.

"We then decided to look into ovarian cancer and discovered that expression of these genes is turned up in this disease. We expected that these genes would promote the spreading of cancer cells but when we switched them on in ovarian cancer cell lines in the laboratory we observed the contrary, a suppression of spread.

"This result was very surprising, and we therefore looked back at the cancers and found that many RNAs, produced from one of the genes, are faulty," Associate Professor Grtzner says. "There have been previous studies in other cancers that have shown these genes actually increase growth and spread of cancer. We are only beg
'/>"/>

Contact: Associate Professor Frank Grützner, University of Adelaide
frank.grutzner@adelaide.edu.au
61-883-134-812
University of Adelaide
Source:Eurekalert

Page: 1 2

Related medicine news :

1. IntegraGen launches ARISk test, a genetic screening tool for autism in high-risk children
2. 2 genetic deletions in human genome linked to the development of aggressive prostate cancer
3. Head, Body Lice Are Genetically Very Similar
4. Certain Genetic Regions May Be Tied to Osteoporosis
5. Study of half siblings provides genetic clues to autism
6. Genetic variants, tobacco exposure and lung cancer risk
7. Research Gets Closer to Genetic Roots of Glaucoma
8. Moffitt researcher awarded GE grant to develop tool to detect breast cancer metastasis genetic risks
9. Genetically modified T cell therapy shown to be safe, lasting in decade-long study of HIV patients
10. Some women may be genetically predisposed to smoking-related hot flashes
11. Genetic abnormalities in benign or malignant tissues predict relapse of prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... (PRWEB) December 22, 2014 Fad diets ... changed. The reason why most fad diets have hung ... The problem with fad diets is that, as the body ... the dieter uncertain of how to reset the metabolism to ... reason, Diet Doc developed their all-inclusive diet plans ...
(Date:12/22/2014)... (PRWEB) December 22, 2014 The founders ... BLS and ACLS online certification provider, are proud to ... . The updated site now features a more user-friendly ... ever to use. , As a company spokesperson ... is now consolidated into a single page during the ...
(Date:12/22/2014)... (PRWEB) December 22, 2014 ... current Ebola virus epidemic are receiving further ... government agencies, nongovernmental organizations (NGOs) and other ... ongoing, healthcare workers, emergency responders, patients and ... such as the CmTP MediDefense system ...
(Date:12/22/2014)... Physicians in China are most eagerly ... of non-Hodgkin’s lymphoma (NHL), according to a new report ... consulting firm. MabThera is the only biologic available to ... form of NHL. , According to Kantar Health’s report, ... of NHL in China has been growing and is ...
(Date:12/22/2014)... OH (PRWEB) December 22, 2014 Explorys, ... three additions to its leadership team: Greg Yarrington as ... of Engineering, and Patrick Wells as Vice President of ... to add 80 new jobs in 2015 to support ... expansion of its platform-as-a-service offerings, and growth of its ...
Breaking Medicine News(10 mins):Health News:Diet Doc Announces the Difference Between Fad Diets and Real Weight Loss Programs to Help Dieters Make the Best Choice 2Health News:Diet Doc Announces the Difference Between Fad Diets and Real Weight Loss Programs to Help Dieters Make the Best Choice 3Health News:Diet Doc Announces the Difference Between Fad Diets and Real Weight Loss Programs to Help Dieters Make the Best Choice 4Health News:ACLS Online Certification Website ACLS-PALS-BLS.com Now Features a New and User-Friendly Layout 2Health News:Novel Biostatic Antimicrobial Technology From Clearstream-mPact Technology Partnership (CmTP) Offers Effective Protection Against Transmission of Ebola Virus 2Health News:Novel Biostatic Antimicrobial Technology From Clearstream-mPact Technology Partnership (CmTP) Offers Effective Protection Against Transmission of Ebola Virus 3Health News:Novel Biostatic Antimicrobial Technology From Clearstream-mPact Technology Partnership (CmTP) Offers Effective Protection Against Transmission of Ebola Virus 4Health News:Novel Biostatic Antimicrobial Technology From Clearstream-mPact Technology Partnership (CmTP) Offers Effective Protection Against Transmission of Ebola Virus 5Health News:Physicians in China See Most Significant Demand for MabThera Biosimilar 2Health News:Physicians in China See Most Significant Demand for MabThera Biosimilar 3Health News:Explorys Continues to Experience Rapid Growth, Adds Three Healthcare IT Executives to Its Leadership Team 2Health News:Explorys Continues to Experience Rapid Growth, Adds Three Healthcare IT Executives to Its Leadership Team 3
... at Wake Forest University Baptist Medical Center (WFUBMC) have discovered ... breast cancer. For the first time, a peptide found in ... of human breast tumors in mice, according to a study ... Patricia E. Gallagher, Ph.D., and E. Ann Tallant, Ph.D., scientists ...
... Hydrocephalus in Ugandan children and other developing countries is ... by previous bacterial infection, according to an international team ... believe that the best approach to this problem is ... grand medical mystery," said Steven Schiff, the Brush Chair ...
... , THURSDAY, Dec. 30 (HealthDay News) -- Certain ... a new study finds. Because of increasing urbanization, ... more than ever before. For example, foxes, raccoons and ... mice, rats, birds and other prey. For this ...
... , , , , , ... , AUDIO: Its not news ... Click here for more information. , ... , , , , , ...
... -- Researchers report that they,ve gained insight into the workings ... in how the body stores fat to protect against future ... be linked to both insulin sensitivity and the survival of ... all these different phenomena," Dr. Philipp Scherer, a professor of ...
... Reporter , THURSDAY, Dec. 29 (HealthDay News) -- As fears ... gripped much of the United States the past two winters, George ... As vice president of human resources for a Fort Lauderdale commercial ... and protect not only the company,s employees but also the tenants ...
Cached Medicine News:Health News:Peptide delivers 1-2 punch to breast cancer in pre-clinical study 2Health News:Infant hydrocephalus, seasonal and linked to farm animals in Uganda 2Health News:Infant hydrocephalus, seasonal and linked to farm animals in Uganda 3Health News:Infant hydrocephalus, seasonal and linked to farm animals in Uganda 4Health News:Consistent exercise associated with lower risk of colon cancer death 2Health News:Consistent exercise associated with lower risk of colon cancer death 3Health News:Research Sheds Light on 'Starvation Hormone' 2Health News:How One Company Fought the Flu 2
(Date:12/22/2014)... 2014  Mark Farrah Associates (MFA), www.markfarrah.com ... of the 2015 marketplace exchange projections and insights ... According to a recent ASPE (Office of ... of Health and Human Services) report, an estimated ... plans through the Marketplace as of October 2014 ...
(Date:12/22/2014)... , Dec. 22, 2014  Pfenex Inc. (NYSE MKT: ... anthrax vaccine, has been filed and is now open ... by the Department of Health and Human Services (HHS), ... "We are extremely pleased to have the ... This represents a significant milestone in our company,s partnership ...
(Date:12/22/2014)... 2014 TWi Biotechnology, Inc., today announced ... AC-201, TWi Biotechnology,s lead drug candidate, from The ... for patent application numbered 201180018154.8.  This ... active metabolite for treatment of type II diabetes.  ... using AC-201 for type II diabetes, and provides ...
Breaking Medicine Technology:Insights into the Marketplace and Individual Market Growth 2Pfenex Announces Active IND and Additional BARDA Funding for Recombinant Anthrax Vaccine Program, Px563L 2Pfenex Announces Active IND and Additional BARDA Funding for Recombinant Anthrax Vaccine Program, Px563L 3TWi Biotechnology Receives Notice of Patent Allowance for Its Lead Drug Candidate AC-201 for the Indication of Type II Diabetes in China 2TWi Biotechnology Receives Notice of Patent Allowance for Its Lead Drug Candidate AC-201 for the Indication of Type II Diabetes in China 3
... 15 This year,s American Friends of Rabin Medical ... to be an unforgettable evening. With Larry King ... being held on the historic Intrepid Sea, Air & Space ... be in attendance, including diplomats, civic, business, medical and philanthropic ...
... , EAST BRUNSWICK, N.J., Oct. 15 Savient Pharmaceuticals, ... of its previously announced underwritten public offering. Prior to ... purchase an additional 645,000 shares of common stock. As ... of its common stock at a price to the ...
Cached Medicine Technology:Larry King to Host 10th Annual American Friends of Rabin Medical Center 'Broadway on the Hudson' Gala 2Larry King to Host 10th Annual American Friends of Rabin Medical Center 'Broadway on the Hudson' Gala 3Savient Pharmaceuticals Announces Closing of Public Offering and Exercise of Over-Allotment Option 2
... a large body for increased stability ... centimeters center-to-center) to resist the wear ... indicators are molded into the body. ... bar electrode styles. Shielded bar electrodes ...
... Cadwell's custom bars have a ... solid, machined contacts (spaced 3 centimeters ... tear of repeated cleaning. Polarity indicators ... convenient, snap-on handle fits our bar ...
The Surgifresh mini has the same rugged construction as the Plume-inator. It is the ideal size for operating room, clinic and office settings. This unit includes a filter test button, hospital grade ...
... Evolutionary refractive lens technology for ... safety and efficacy, demonstrates quality of ... contact lens correction. The lens is ... and is now available for the ...
Medicine Products: