Navigation Links
Genetic mutations that cause common childhood brain tumors identified
Date:7/22/2012

STANFORD, Calif. Researchers at the Stanford University School of Medicine and Lucile Packard Children's Hospital have identified several gene mutations responsible for the most common childhood brain tumor, called medulloblastoma, adding evidence to the theory that the diagnosis is a group of genetically distinct cancers with different prognoses. These and accompanying findings are likely to lead to less-toxic, better-targeted treatment approaches over the next two years, the researchers said.

"We tend to treat all medulloblastomas as one disease without taking into account how heterogeneous the tumors are at the molecular level," said Yoon-Jae Cho, MD, an assistant professor of neurology and neurological sciences at Stanford, a pediatric neurologist at Packard Children's and the senior author of the new research. "This paper represents a finer-grained view of the genetic landscape of these tumors and provides us with some leads on how to develop new therapies."

The research, which will appear online in Nature July 22, is part of a large, ongoing effort to characterize genetic errors in medulloblastoma. Two companion studies on which Cho is a co-author will be published simultaneously with his paper. The three papers came from a consortium that involves scientists at Stanford, Packard Children's, the Broad Institute, Children's Hospital Boston, the Dana-Farber Cancer Institute, the German Cancer Research Center, Brandeis University and the Hospital for Sick Children in Toronto.

Current treatment for medulloblastoma, which originates in the cerebellum and affects about 250 U.S. children each year, begins with surgery to remove as much of the tumor as possible. Patients then receive a combination of radiation and chemotherapy, but the treatments are not tailored to the tumor's genetic characteristics.

Cho's team extracted DNA from 92 medulloblastoma tumors and compared it with DNA from matched blood samples from the sam
'/>"/>

Contact: Erin Digitale
digitale@stanford.edu
650-724-9175
Stanford University Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Genetic markers for testosterone and estrogen level regulation identified
2. BUSM researchers identify genetic markers for testosterone, estrogen level regulation
3. Scientists discover melanoma-driving genetic changes caused by sun damage
4. Decline of immune system with aging may have a genetic cause
5. U-M researchers identify new genetic cause for chronic kidney disease
6. Turning off key piece of genetic coding eliminates toxic effect of statins, SLU research finds
7. Moffitt Cancer Center study validates activity of rare genetic variant in glioma
8. Trust hormone oxytocin found at heart of rare genetic disorder
9. Stanford study shows opiates side effects rooted in patients genetics
10. Holy glycosylation! New bat signal flags distressed cells in childhood genetic diseases
11. Study sheds new light on role of genetic mutations in colon cancer development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... HealthDay Reporter THURSDAY, July ... HIV who was thought to be cured by immediate and ... levels of the AIDS-causing virus in her bloodstream, disappointed federal ... years old, had remained virus-free even though she stopped taking ... hoped her remission would open the door to a functional ...
(Date:7/11/2014)... The Europe Well Intervention Market report defines and segments ... revenue forecast. The well intervention services market in Europe is ... $3.4 billion by 2018, at a CAGR of 7% from ... Europe Well Intervention Market report, to get an idea of ... the segmentation in the Europe well intervention market, and is ...
(Date:7/11/2014)... (HealthDay News) -- Children who have emergency surgery ... and potentially even death than those who have ... However, the Johns Hopkins researchers noted that the ... analyzed data on nearly 440,000 simple emergency surgeries ... a 22-year period. The surgeries are considered ...
(Date:7/11/2014)... According to a new market research ... Communication Technology (ZigBee, Z-Wave, Bluetooth, Wi-Fi, NFC, RFID), Application ... Transportation, Agriculture) & Geography - Global Trends & Forecasts ... Things market was worth $1029.5 Billion in 2013, and ... an estimated CAGR of 4.08% from 2014 to 2020. ...
(Date:7/11/2014)... Researchers from The Miriam Hospital have found that ... significantly higher rates of smoking than those without ... less likely to attempt quitting than those without ... be sufficient for this population. The study and ... print in the American Journal of Public ...
Breaking Medicine News(10 mins):Health News:Mississippi Girl Thought Cured of HIV Shows Signs of Infection 2Health News:Mississippi Girl Thought Cured of HIV Shows Signs of Infection 3Health News:Europe Well Intervention Services Market is Expected to Reach $3.4 Billion by 2018 - New Report by MicroMarket Monitor 2Health News:Europe Well Intervention Services Market is Expected to Reach $3.4 Billion by 2018 - New Report by MicroMarket Monitor 3Health News:Emergency Surgeries on Weekends Riskier for Kids: Study 2Health News:Internet of Things Technology & Application Market Worth $1423.09 Billion by 2020 – New Report by MarketsandMarkets 2Health News:Internet of Things Technology & Application Market Worth $1423.09 Billion by 2020 – New Report by MarketsandMarkets 3Health News:Internet of Things Technology & Application Market Worth $1423.09 Billion by 2020 – New Report by MarketsandMarkets 4Health News:Miriam Hospital study examines smoking prevalence 2
... -- The rising prevalence of obesity around the globe ... on healthcare systems and on overall economies. A major ... these burdens to inform public policies. Using a ... consequences from rising obesity rates in the United States ...
... , FRIDAY, Aug. 26 (HealthDay News) -- Scientists ... most common noncancerous tumors in women of childbearing age. ... discomfort, occur in 60 percent of women by the age ... the most common reason for hysterectomy. Despite their importance, ...
... THURSDAY, Aug. 25 (HealthDay News) -- A new scoring system might ... how much time they have left so they can prepare for ... in Palliative Care Study (PiPS) predictor model, the scoring system plugs ... or months a person with advanced cancer most likely has to ...
... People with lower socioeconomic status are much more likely to ... educated, according to a recent UC Davis study. Published online ... that this risk persists even with long-term progress in addressing ... elevated cholesterol. "Being poor or having less than ...
... , THURSDAY, Aug. 25 (HealthDay News) -- One of the ... was the secrecy that shrouded products he was about to ... iPad -- creating tremendous consumer interest. Jobs, announcement Wednesday ... the hugely successful technology company he co-founded in a northern ...
... News) -- The number of obese people in the United States ... 2030, and the number of obese people in the United Kingdom ... predicts. Obesity-related diseases and health care costs will soar as ... The Lancet . Already, the U.S. and U.K. obesity rates ...
Cached Medicine News:Health News:65 million more obese adults in the US and 11 million more in the UK expected by 2030 2Health News:65 million more obese adults in the US and 11 million more in the UK expected by 2030 3Health News:Scoring System May Tell the Dying How Long They Have to Live 2Health News:Lower socioeconomic status linked with heart disease despite improvements in other risk factor 2Health News:Steve Jobs Faces Uphill Battle Against Cancer: Experts 2Health News:Steve Jobs Faces Uphill Battle Against Cancer: Experts 3Health News:Obesity Continues to Balloon in U.S. and U.K.: Study 2
(Date:7/10/2014)... 2014 Integrated Silicon Solution, Inc. (Nasdaq: ... analog IC solutions, today announced that it will host ... at 7:00 a.m. Pacific Time (10:00 a.m. Eastern Time) ... 2014 third quarter ended June 30, 2014. ... before 6:50 a.m. Pacific time on July 24, 2014.  ...
(Date:7/10/2014)... July 10, 2014   Ventana Medical Systems, Inc. ... it has entered into an agreement with Merck KGaA, ... EMD Serono in the United States ... with Merck KGaA,s biopharmaceutical division on the development and ... target using Ventana,s proprietary diagnostic assays. In alignment with ...
(Date:1/15/2014)... 15, 2014 Sono-Tek Corporation (OTC BB: SOTK) today announced ... 2013, compared to sales of $2,202,000 for the prior year ... quarter has also shown growth over the preceding quarter,s sales, ... this fiscal year. Markets that experienced sales increases over the ...
Breaking Medicine Technology:Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 2Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 3Sono-Tek Announces Third Quarter Results 2Sono-Tek Announces Third Quarter Results 3Sono-Tek Announces Third Quarter Results 4
... Sanofi-aventis (EURONEXT: SAN and NYSE: ... REGN ) today announced results from the Phase ... Trap) for the second-line treatment of non-small cell lung ... the chemotherapy drug docetaxel did not meet the pre-specified ...
... Nephros, Inc. (OTC Bulletin Board: NEPH ), ... for therapeutic applications, infection control, and water purification, today ... placement that together resulted in gross proceeds of approximately ... by Nephros from the rights offering and private placement ...
Cached Medicine Technology:Sanofi-aventis and Regeneron Report Top-line Results from Phase III Study with aflibercept (VEGF Trap) in Second-Line Non-Small Cell Lung Cancer 2Sanofi-aventis and Regeneron Report Top-line Results from Phase III Study with aflibercept (VEGF Trap) in Second-Line Non-Small Cell Lung Cancer 3Sanofi-aventis and Regeneron Report Top-line Results from Phase III Study with aflibercept (VEGF Trap) in Second-Line Non-Small Cell Lung Cancer 4Sanofi-aventis and Regeneron Report Top-line Results from Phase III Study with aflibercept (VEGF Trap) in Second-Line Non-Small Cell Lung Cancer 5Sanofi-aventis and Regeneron Report Top-line Results from Phase III Study with aflibercept (VEGF Trap) in Second-Line Non-Small Cell Lung Cancer 6Sanofi-aventis and Regeneron Report Top-line Results from Phase III Study with aflibercept (VEGF Trap) in Second-Line Non-Small Cell Lung Cancer 7Nephros Announces Completion of $3.2 Million Financing Through Rights Offering and Private Placement Transactions 2Nephros Announces Completion of $3.2 Million Financing Through Rights Offering and Private Placement Transactions 3Nephros Announces Completion of $3.2 Million Financing Through Rights Offering and Private Placement Transactions 4
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: