Navigation Links
Genetic mutations associated with increased PSA and prostate cancer
Date:12/2/2010

Austrian researchers have uncovered mutations throughout the mitochondrial genome that are associated with prostate cancer. An exciting aspect of the study, published by Cell Press on December 2 in the American Journal of Human Genetics, is the association of tRNA mutations with elevated levels of prostate-specific antigen (PSA) in Austrian men diagnosed with various stages of prostate cancer.

Prostate cancer is among the most prevalent cancers diagnosed in the United States and Europe. The most common and noninvasive way to detect prostate cancer is to check PSA levels. This is a routine part of men's health checks starting around the age of 50. Elevated PSA levels indicate the possibility of prostate cancer. Prostate biopsies are used for verification of PSA results and cancer diagnosis. Treatment may include surgery, radiation, or chemotherapy. "Identifying genetic variants associated with prostate cancer and its primary biomarker is an exciting accomplishment," says Dr. Anita Kloss-Brandsttter, the lead author of this study.

Recognizing the important role mtDNA mutations have been found to play in development and progression of many types of cancer, Dr. Kloss-Brandsttter and colleagues set out to sequence the entire mitochondrial genome in 30 prostate cancer patients. "The influence of mtDNA on the origin and progression of prostate cancer is still not understood, leaving much to be discovered," says Dr. Kloss-Brandsttter. The group used a high-quality sequencing approach to detect differences in mtDNA sequence between cancerous and noncancerous tissue from the same 30 men. "It is the first study targeting the entire mitochondrial genome in prostate cancer and benign tissue from the same patient with a superior sequencing strategy," notes Dr. Kloss-Brandsttter.

By examining both the frequency and types of somatic mtDNA mutations in prostate cancer patients, Dr. Kloss-Brandsttter and colleagues were able to identify several genetic changes having clinical significance. They suggest that, "sequencing of selected mitochondrial regions will likely result in a mutation spectrum useful for prognosis." Perhaps the most striking finding of the study is the association between somatic tRNA mutations and PSA levels at diagnosis. "Patients with a somatic tRNA mutation had a significantly higher PSA value at diagnosis than did patients without a somatic tRNA mutation," explains Dr. Kloss-Brandsttter. "These findings will potentially help others monitor malignant transformation, tumor progression, and metastasis," she says.


'/>"/>

Contact: Elisabeth (Lisa) Lyons
elyons@cell.com
617-386-2121
Cell Press
Source:Eurekalert

Related medicine news :

1. Novel genetic mutation that causes the most common form of eye cancer discovered
2. Rare, Severe Form of Morning Sickness Appears to Be Genetic
3. Our normal genetics may influence cancer growth, too
4. Academies of science call for amendments to impracticable Genetic Diagnostics Act
5. New research shows genetic test for lung cancer risk prompts smokers to quit
6. Genetic Deletion Linked to Raised Risk of Autism, Schizophrenia
7. ASHG 2010: New research on implications of direct-to-consumer and clinical genetic testing
8. Possible Genetic Switches for Blood Sugar Control Detected
9. Newfoundland researchers crack the genetic code of a sudden death cardiac killer
10. Genetics May Play Role in Vitamin E Levels
11. Gene activity in the brain depends on genetic background
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... 2016 , ... "FCPX editors can now reveal their media with growing colorful ... Christina Austin - CEO of Pixel Film Studios. , ProSlice Color brings the ... can now reveal the media of their split screens with growing colorful panels. , ...
(Date:6/27/2016)... , ... June 27, 2016 ... ... the patient payment industry today announced its strategic partnership with Connance, a ... workflows. , The two companies’ proven, proprietary technology combine to provide health ...
(Date:6/27/2016)... ... 2016 , ... TopConsumerReviews.com recently awarded their highest five-star rating to Best Buy ... in the United States and Canada wear eyeglasses. Once considered to be a purely ... make a fashion statement. Even celebrities use glasses as a way of creating an ...
(Date:6/26/2016)... ... ... On June 10-11, 2016, A Forever Recovery, a holistic treatment center for ... Table in Battle Creek, MI, where the rehabilitation facility is located. This annual celebration ... world’s leading providers of cereal and other breakfast foods. Its residents often refer to ...
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet ... product that was developed to enhance the health of felines. The formula is all-natural ... two main herbs in the PawPaws Cat Kidney Support Supplement Soft Chews ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016  Collagen Matrix, Inc., ("Collagen ... and manufacturing of collagen and mineral based medical ... that Bill Messer has joined the ... further leverage the growing portfolio of oral surgery, ... Bill joins the Collagen Matrix executive team ...
(Date:6/24/2016)... , June 24, 2016 ... of the "Structural Electronics 2015-2025: Applications, Technologies, ... In-Mold Electronics, Smart Skin, ... Photovoltaics Structural electronics involves electronic ... load-bearing, protective structures, replacing dumb structures such as ...
(Date:6/24/2016)... , June 24, 2016 Research and ... Market for Companion Diagnostic Tests" report to their offering. ... for Companion Diagnostics The World Market for ... personalized medicine diagnostics. Market analysis in the report includes the ... Market (In Vitro Diagnostic Kits) by Region (N. America, EU, ...
Breaking Medicine Technology: