Navigation Links
Genetic mutations associated with increased PSA and prostate cancer
Date:12/2/2010

Austrian researchers have uncovered mutations throughout the mitochondrial genome that are associated with prostate cancer. An exciting aspect of the study, published by Cell Press on December 2 in the American Journal of Human Genetics, is the association of tRNA mutations with elevated levels of prostate-specific antigen (PSA) in Austrian men diagnosed with various stages of prostate cancer.

Prostate cancer is among the most prevalent cancers diagnosed in the United States and Europe. The most common and noninvasive way to detect prostate cancer is to check PSA levels. This is a routine part of men's health checks starting around the age of 50. Elevated PSA levels indicate the possibility of prostate cancer. Prostate biopsies are used for verification of PSA results and cancer diagnosis. Treatment may include surgery, radiation, or chemotherapy. "Identifying genetic variants associated with prostate cancer and its primary biomarker is an exciting accomplishment," says Dr. Anita Kloss-Brandsttter, the lead author of this study.

Recognizing the important role mtDNA mutations have been found to play in development and progression of many types of cancer, Dr. Kloss-Brandsttter and colleagues set out to sequence the entire mitochondrial genome in 30 prostate cancer patients. "The influence of mtDNA on the origin and progression of prostate cancer is still not understood, leaving much to be discovered," says Dr. Kloss-Brandsttter. The group used a high-quality sequencing approach to detect differences in mtDNA sequence between cancerous and noncancerous tissue from the same 30 men. "It is the first study targeting the entire mitochondrial genome in prostate cancer and benign tissue from the same patient with a superior sequencing strategy," notes Dr. Kloss-Brandsttter.

By examining both the frequency and types of somatic mtDNA mutations in prostate cancer patients, Dr. Kloss-Brandsttter and colleagues were able to identify several genetic changes having clinical significance. They suggest that, "sequencing of selected mitochondrial regions will likely result in a mutation spectrum useful for prognosis." Perhaps the most striking finding of the study is the association between somatic tRNA mutations and PSA levels at diagnosis. "Patients with a somatic tRNA mutation had a significantly higher PSA value at diagnosis than did patients without a somatic tRNA mutation," explains Dr. Kloss-Brandsttter. "These findings will potentially help others monitor malignant transformation, tumor progression, and metastasis," she says.


'/>"/>

Contact: Elisabeth (Lisa) Lyons
elyons@cell.com
617-386-2121
Cell Press
Source:Eurekalert

Related medicine news :

1. Novel genetic mutation that causes the most common form of eye cancer discovered
2. Rare, Severe Form of Morning Sickness Appears to Be Genetic
3. Our normal genetics may influence cancer growth, too
4. Academies of science call for amendments to impracticable Genetic Diagnostics Act
5. New research shows genetic test for lung cancer risk prompts smokers to quit
6. Genetic Deletion Linked to Raised Risk of Autism, Schizophrenia
7. ASHG 2010: New research on implications of direct-to-consumer and clinical genetic testing
8. Possible Genetic Switches for Blood Sugar Control Detected
9. Newfoundland researchers crack the genetic code of a sudden death cardiac killer
10. Genetics May Play Role in Vitamin E Levels
11. Gene activity in the brain depends on genetic background
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2017)... ... 2017 , ... International Protein, a company based out of Australia that focuses ... January ECRM trade show in Hilton Head, SC. , International Protein was founded ... a line of products that would elevate her fitness regime. At this ECRM trade ...
(Date:1/20/2017)... ... January 20, 2017 , ... ... sugar-free alternative VW+ 002. The drinks have been produced in collaboration with Zlatan ... perform during your workout. , After a successful launch in Sweden last year, ...
(Date:1/20/2017)... ... 20, 2017 , ... “Code Word: Chocolate Biscuit”: a biographical account following a man who went ... creation of published author, Marlyn Ivey, born in Lynn Haven, Florida and at the age ... at 19 years of age, he joined the Navy and got married right out of ...
(Date:1/20/2017)... ... ... in Suffolk”: a story of love, secrets, and mystery. “Christmas in Suffolk” is ... works in a daycare and looks for inspiration in the local coffee shop as ... Seymour’s new book is an adventure of love and secrets. , After ...
(Date:1/20/2017)... ... ... “The Land of More and More”: a brilliant story for children and adults ... and achievable answer. “The Land of More and More” is the creation of published ... Indiana where he works with the children’s ministry department. , Michael says that ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... , Jan. 19, 2017 ViewRay, Inc. ... a federal institution supporting research in Germany ... and patient treatments at the University Clinic Heidelberg as ... The MRIdian Linac program will be headed by ... also heads radiation oncology at the German Cancer Research ...
(Date:1/19/2017)... 19, 2017   Science Exchange , the leading ... that the first five replication studies from the ... published in eLife today. Despite intense scrutiny around ... practical evaluation of reproducibility rates that may identify ... other assessments of reproducibility, the results of this ...
(Date:1/19/2017)... , January 19, 2017 ... Option to Address Motor Symptoms and Motor Complications ... ...      (Logo: http://photos.prnewswire.com/prnh/20151014/276718LOGO) ... , European Neurological Review,2016;11(Suppl. 2): 2-15, http://www.touchneurology.com/articles/safinamide-new-therapeutic-option-address-motor-symptoms-and-motor-complications-mid-late ...
Breaking Medicine Technology: