Navigation Links
Genetic mutation linked to asbestos exposure
Date:6/15/2011

Mice inhabiting an area known for its high concentration of asbestos-contaminated dust, have a higher level of genetic somatic mutations, compared with other regions where asbestos pollution levels are lower. This has been shown in a new study carried out by Dr. Rachel Ben-Shlomo and Dr. Uri Shanas of the University of Haifa's Department of Biology in Oranim. "This study clearly indicates that there is a link between the higher levels of asbestos in the environment and the frequency of genetic somatic mutations in the mammals," the scientists said.

Earlier studies of asbestos have already shown that the thin fibers, which penetrate the body by inhalation or through consumption of food contaminated with the material, not only cause certain cancers but also genetic mutations in DNA structures. It is also known that asbestos is a material that decomposes slowly, over many years. Data from the Israeli Ministry of Health indicate a rise in the number of cancer patients from exposure to asbestos in the Western Galilee region of northern Israel, and therefore the scientists set out to examine whether genetic mutations are found in the mouse population living in its northern town of Nahariya. They chose to probe mutations in mice because their generations are renewed every three months, so it could be assumed for the study that dozens of generations of this sample population in Nahariya had already been exposed to the fibers.

Wild mice from two locations were sampled one group living close to a factory that manufactured asbestos-based products in Nahariya during 1952-1997, and a second group from a town located 50 kilometers, or 31 miles, from Nahariya and where no known asbestos pollutants are found. Samples were taken from both groups and six sites in the DNA were examined for genetic differences between the groups.

The results indicated differences between the groups' DNA and that the Nahariya-based mice had higher levels of genetic somatic mutations.

"These findings teach us that the pollutive, mutagenic asbestos increases somatic mutational frequency, which can in turn heighten the chances of developing cancerous growths," the researchers concluded.


'/>"/>

Contact: Rachel Feldman
rfeldman@univ.haifa.ac.il
972-482-88722
University of Haifa
Source:Eurekalert

Related medicine news :

1. Certain genetic profiles associated with recurrence-free survival for non-small cell lung cancer
2. Obstructive Sleep Apnea in Kids May Have Genetic Cause
3. Epigenetic signals differ across alleles
4. Study reveals genetic link between mammographic density and breast cancer
5. Genetic Risk Score Doesnt Spot Heart Trouble in Women
6. Penn researchers find genetic link to leukemias with an unknown origin
7. Scientists Spot Genetic Fingerprints of Individual Cancers
8. Genetic health risks in children of assisted reproductive technology
9. Genetic Mutation Linked to Prostate Cancer in Blacks
10. Protecting the brain from of a deadly genetic disease
11. Protecting the brain from a deadly genetic disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2017)... ... September 21, 2017 , ... Demonstrating a consistent ... health departments have been awarded five-year accreditation status through the Public Health ... being served by a PHAB-accredited health department now extend to more than ...
(Date:9/21/2017)... ... September 21, 2017 , ... Preora Diagnostics Inc. , ... tests, has received two prestigious recognitions that acknowledge the promise of its PWS ... Preora has been named a Top 100 Finalist for the 16th annual Chicago ...
(Date:9/21/2017)... , ... September 21, 2017 , ... ... offices serving communities in northern Alabama and Georgia, is embarking on an extended ... by utilizing modern early detection methods. , US Breast Cancer statistics show ...
(Date:9/20/2017)... ... September 20, 2017 , ... On ... Best Places to Work in the Research Triangle for 2017. , Winners were ... company had to meet a threshold in employee participation--a percentage that varies based ...
(Date:9/20/2017)... ... September 20, 2017 , ... Demand generation pioneer True ... edition of MarTech: The Marketing Tech Conference October 2–4, at the Hynes Convention ... speakers — representing such thought-leading companies as JP Morgan Chase, GE Digital, ...
Breaking Medicine News(10 mins):
(Date:9/1/2017)... PALMER, Mass. , Sept. 1, 2017 ... Complete HealthCare Solutions, Inc , highlights opportunities for growth ... Street Journal report that Marlin Equity is seeking a ... is an annual award-winning 22-year-old healthcare solutions Value Added ... market.  "As the ...
(Date:8/29/2017)... -- ivWatch, LLC, the leading provider of continuous monitoring devices for ... awarded an Innovative Technology contract from Vizient, Inc., the largest member-driven ... ... early detection of peripheral IV infiltration and extravasation events ... The Innovative Technology contract was awarded to ivWatch based ...
(Date:8/25/2017)... ), an Irish medtech company, today announced that it has commenced working ... Bassetlaw, England . The collaboration sees the company,s ... national NHS Test Bed programme exploring new models of care. ... Innovation Zed ... accessory for disposable insulin pen users, automatically collects and records pen usage ...
Breaking Medicine Technology: