Navigation Links
Genetic mutation found in peripheral artery disease
Date:2/22/2008

The finding, appearing online in the journal Circulation, is the first to document a genetic mutation linked to PAD. Although the work was done in mice, researchers say it is likely to give them new insight into how PAD develops and progresses in humans.

Dr. Brian Annex, professor of medicine and director of vascular medicine at Duke, says the study stemmed directly from his clinical experience. Over and over, Id see two patients show up at the same time. They would be the same sex, same age, have identical risk factors and have similar blockages in their arteries. One of them would experience very slow progression of the disease, while the other would face limb loss or death within six months. I just knew there just had to be a genetic basis for it.

Peripheral arterial disease occurs when major arteries in the legs become clogged with plaque, a fatty build-up thats similar to the deposits in coronary arteries that can lead to a heart attack. Symptoms range from leg pain brought on by walking that goes away with rest thats the more benign form of the disease to a more serious form, marked by continuous pain and sores and ulcers on the legs that often lead to amputation.

Annex says the mild form rarely progresses into the more severe form. In reality, we may be looking at two types of diseases, although weve always thought of PAD as one.

Annex had the perfect participants for the study right at his fingertips: two strains of mice with surgically-induced blocked blood flow that mimicked human response to PAD. One strain recovered well, showing restored blood flow and little tissue death; the other had greater tissue loss and poor recovery of normal blood flow.

In collaboration with Dr. Douglas Marchuk, a professor of molecular genetics and microbiology at Duke, researchers crossbred the two strains and eventually isolated a mouse that enabled them to identify a relatively small region on chromosome 7 that appears to protect the mice from the consequences of the surgically-induced, PAD-like injury.

Essentially, we now have a field of about 20 genes that we think may be involved in shaping the way peripheral artery disease develops, says Annex. At this point, we are not certain which ones are playing an active role, however. Still, we feel strongly that our discovery opens a new wave of investigation that may one day yield novel prevention strategies or treatments.


'/>"/>

Contact: Michelle Gailiun
michelle.gailiun@duke.edu
919-660-1306
Duke University Medical Center
Source:Eurekalert

Related medicine news :

1. Many Parents Share Genetic Test Findings With Kids
2. Genetic predisposition increases childhood asthma risk
3. New Alzheimers findings: High stress and genetic risk factor lead to increased memory decline
4. Test Spots Genetic Damage Done by Smoking
5. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
6. Scientists highlight benefits of genetic research in sport, but warn of ethical concerns
7. Genetics Hold Promise, Challenges for Cancer Care
8. Researchers genetically engineer micro-organisms into tiny factories
9. Study Questions Genetic Screening for Treatable Diseases
10. Researchers provide genetic associations from a genome-wide scan for cardiovascular disease traits
11. Genetic variation affects smoking cessation treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/19/2017)... ... January 19, 2017 , ... MB Business Capital, a ... senior credit facility to Sunrise, Florida-based Management Health Systems, LLC, dba MedPro Healthcare ... a recapitalization of MedPro led by Harren Equity Partners. Brightwood Capital Advisors ...
(Date:1/19/2017)... PETALUMA, CA (PRWEB) , ... January 19, 2017 ... ... new Tranquility acoustic and privacy panel system. , The Tranquility privacy panel ... to a collaborative office environment. Tranquility panels help reduce noise and provide the ...
(Date:1/19/2017)... ... January 19, 2017 , ... Tribble Insurance Agency, a ... eastern Virginia region, is inaugurating a charity event to honor Chad Phillip Dermyer, a ... duty last year, Chad Phillip Dermyer and his fellow officers were conducting routine stops ...
(Date:1/19/2017)... ... January 19, 2017 , ... For the second consecutive ... of Connecticut (RMACT) have earned “Top Doctor” awards. Dr. Mark Leondires, Dr. Spencer ... each been chosen by their peers for the 2017 list based on their ...
(Date:1/19/2017)... Marriottsville, MD (PRWEB) , ... January 19, 2017 , ... ... launched six new clients into the US market. , Over the past 20 years ... the past 4 weeks SFI has launched six new clients into the US market. ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... ALAMEDA, Calif. , Jan. 18, 2017 /PRNewswire/ ... (MPI) solutions has entered into an agreement with ... for the Momentum MPI imaging system based on ... VivoQuant will be distributed as a complete MPI ... to enable quantitative nanoparticle or cell imaging in ...
(Date:1/18/2017)... , Jan. 18, 2017  EnteroMedics Inc. (NASDAQ: ... devices using neuroblocking technology to treat obesity, metabolic ... pricing of an underwritten public offering of units ... deducting underwriting discounts and commissions and offering expenses ... comprised of Class A Units, priced at a ...
(Date:1/18/2017)... Jan. 18, 2017  Adaptive Sound Technologies, Inc. (ASTI), the ... partnership with Hyatt Place Nashville/Downtown to deliver the best ... sleep therapy machines in over two hundred of its ... important parts of having a great stay is sleeping ... Hyatt Place Nashville/Downtown. "We,re pleased to be able to ...
Breaking Medicine Technology: