Navigation Links
Genetic mutation found in peripheral artery disease
Date:2/22/2008

The finding, appearing online in the journal Circulation, is the first to document a genetic mutation linked to PAD. Although the work was done in mice, researchers say it is likely to give them new insight into how PAD develops and progresses in humans.

Dr. Brian Annex, professor of medicine and director of vascular medicine at Duke, says the study stemmed directly from his clinical experience. Over and over, Id see two patients show up at the same time. They would be the same sex, same age, have identical risk factors and have similar blockages in their arteries. One of them would experience very slow progression of the disease, while the other would face limb loss or death within six months. I just knew there just had to be a genetic basis for it.

Peripheral arterial disease occurs when major arteries in the legs become clogged with plaque, a fatty build-up thats similar to the deposits in coronary arteries that can lead to a heart attack. Symptoms range from leg pain brought on by walking that goes away with rest thats the more benign form of the disease to a more serious form, marked by continuous pain and sores and ulcers on the legs that often lead to amputation.

Annex says the mild form rarely progresses into the more severe form. In reality, we may be looking at two types of diseases, although weve always thought of PAD as one.

Annex had the perfect participants for the study right at his fingertips: two strains of mice with surgically-induced blocked blood flow that mimicked human response to PAD. One strain recovered well, showing restored blood flow and little tissue death; the other had greater tissue loss and poor recovery of normal blood flow.

In collaboration with Dr. Douglas Marchuk, a professor of molecular genetics and microbiology at Duke, researchers crossbred the two strains and eventually isolated a mouse that enabled them to identify a relatively small region on chromosome 7 that app
'/>"/>

Contact: Michelle Gailiun
michelle.gailiun@duke.edu
919-660-1306
Duke University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Many Parents Share Genetic Test Findings With Kids
2. Genetic predisposition increases childhood asthma risk
3. New Alzheimers findings: High stress and genetic risk factor lead to increased memory decline
4. Test Spots Genetic Damage Done by Smoking
5. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
6. Scientists highlight benefits of genetic research in sport, but warn of ethical concerns
7. Genetics Hold Promise, Challenges for Cancer Care
8. Researchers genetically engineer micro-organisms into tiny factories
9. Study Questions Genetic Screening for Treatable Diseases
10. Researchers provide genetic associations from a genome-wide scan for cardiovascular disease traits
11. Genetic variation affects smoking cessation treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... Cancer Center paint a relatively optimistic picture of women,s ... have spread to the chest wall or skin, but ... skin, regardless of size and whether they have involved ... and called "locally advanced" tumors, suggesting that they are ... survival. Locally advanced breast cancers of this and other ...
(Date:7/9/2014)... By looking at ... structure and function, personality, life experiences and genetics, researchers can ... binge drinking within the next two years. Impulsivity, hopelessness, sensation-seeking ... events and a family history of drug use contribute to ... child had had a single drink at age 14 was ...
(Date:7/9/2014)... flatulence and have a reputation for being highly toxic, but ... now being being found to offer potential health benefits in ... and dementia. A new compound (AP39), designed and made at ... therapies, by targeting delivery of very small amounts of the ... , Scientists in Exeter have already found that the compound ...
(Date:7/9/2014)... Previous studies linking older age with kidney and heart ... kidney donation among older adults. However, in the first ... the Perelman School of Medicine at the University of ... above) enjoy similar life expectancy and cardiovascular health as ... kidneys. In light of the ever increasing organ transplant ...
(Date:7/8/2014)... Older kidney donors enjoy similar longevity and cardiovascular health ... study published in the American Journal of Transplantation ... individuals considering donation and the transplant professionals caring for ... donation by individuals aged 55 years and older has ... kidney disease, and heart disease, the removal of a ...
Breaking Medicine News(10 mins):Health News:Fox Chase researchers recommend updating the staging criteria for breast cancer diagnoses 2Health News:Fox Chase researchers recommend updating the staging criteria for breast cancer diagnoses 3Health News:What drives a child to abuse alcohol? 2Health News:Rotten egg gas holds key to healthcare therapies 2Health News:Penn study finds living kidney donation does not increase risk of death or heart disease for older 2Health News:Study finds kidney donation safe for healthy older adults 2
... most popular cause of death among men and women ... 2005,with approximately 6% of those recorded as copycat suicides. ... to sensationalize suicides, adding that a significant number of these ... are sensing that there is more reporting of suicide and ...
... In Namibia people are affected by polio and as ... plans to conduct a three-day mass vaccination campaign to ... Namibian dollars, said Kalumbi Shangula, permanent secretary in the ... been affected by the outbreak in the southern African ...
... used an animal vaccine supplied to it "by mistake" ... doctor //and storekeeper, authorities said Wednesday. ... Pvt Ltd, which provided the vaccine to the hospital. ... at the hospital found out that medicines meant for ...
... dermatomyositis (JDM), a protein present in chronic inflammatory conditions ... trigger T-cells response – which is associated with the ... finds. ,The specific response has earlier been ... is known about the role of HSP60 in inflammatory ...
... Delhi Consumer Court has directed a city-based private hospital to ... 'inability to walk or move on account //of the negligence' ... ,The North District Consumer Disputes Redressal Forum comprising President K ... acting on the complaint of one Shiv Kumar Sharma, also ...
... Finally there is some scientific research to explain mysteries like ... said in a perfectly audible volume to them. //It has ... to them is sometimes inaudible or thunderous torture for someone ... high-pitched noises, which adults can't. The House Ear Institute in ...
Cached Medicine News:Health News:Proteins – A New Way to Treat Children's Muscle Diseas 2
(Date:1/14/2014)... /PRNewswire-iReach/ -- Acumed,s new SLIC Screw System - a ... to place and insert the screw accurately - offers ... ligament) repair or reconstruction as it holds the bones ... http://photos.prnewswire.com/prnh/20140114/MN45636 ) The SLIC Screw ...
(Date:1/14/2014)... 2014   NuAire , a manufacturer of ergonomically designed laboratory ... Koki of Japan to sell and ... . NuAire will utilize its network of sales professionals throughout ... to offer assistance in application use, product benefits and ...
(Date:1/14/2014)... N.Y. , Jan. 14, 2014   Oligomerix, Inc. , ... modifying therapeutics for Alzheimer,s disease (AD) and related neurodegenerative ... to Valhalla, NY as of ... laboratory space at New York Medical College. ...
Breaking Medicine Technology:Acumed introduces the Scapho-Lunate Inter Carpal (SLIC) Screw System 2Acumed introduces the Scapho-Lunate Inter Carpal (SLIC) Screw System 3NuAire announces sales and service of Hitachi Koki centrifuges in North America 2Oligomerix Relocates Corporate Headquarters and Secures Additional Laboratory Space from New York Medical College 2
... senior health policy analyst for Consumers Union, will urge Congress ... before the House Energy & Commerce Health Subcommittee.  The ... of the Medical Device User Fee Act beginning at 10:15 ... Recent safety problems with metal hip implants ...
... LA JOLLA, Calif., Feb. 15, 2012 Celladon ... and development of innovative treatments for cardiovascular diseases, ... million equity financing to advance its lead investigational ... failure. The financing was led by new investor ...
Cached Medicine Technology:Consumers Union to Testify for Stronger Medical Device Safety Oversight at House Hearing Today 2Consumers Union to Testify for Stronger Medical Device Safety Oversight at House Hearing Today 3Celladon Corporation Completes $43 Million Financing to Advance MYDICAR® for the Treatment of Heart Failure 2Celladon Corporation Completes $43 Million Financing to Advance MYDICAR® for the Treatment of Heart Failure 3
... Delivers the advanced performance benefits ... strength, versatility, and durability ... that augments the effectiveness of ... floor reconstruction. Comprised of sterile, ...
... (also known as the VOCARE) Bladder System ... used by people with spinal cord injuries ... demand. A secondary use of the device ... promote penile erection.,The Bladder System includes surgically ...
Used for dilation of a tract to the kidney for removal of stones. Supplied sterile in peel-open packages. Intended for one-time use....
... Urinary Control offers a revolutionary approach ... symptoms of overactive bladder, including urinary ... urgency-frequency alone or in combination in ... not tolerate more conservative treatments. Medtronic ...
Medicine Products: