Navigation Links
Genetic markers could predict prostate cancer in younger men, U-M study finds

ANN ARBOR, Mich. Prostate cancer has become more common in younger men, and it's often more aggressive in these men. A new study from researchers at the University of Michigan Comprehensive Cancer Center has found that a series of genetic mutations could help detect this early onset prostate cancer.

Researchers believe that genetics and traditional screening methods could play a role in predicting the risk of prostate cancer in younger men.

"This is a potential opportunity to combine PSA testing with genetic markers to determine who has significant prostate cancer. It could be a combination of age and family history that could help us determine who should be tested with PSA and a panel of genetic markers," says study author Kathleen Cooney, M.D., Frances and Victor Ginsberg Professor of Hematology/Oncology and division chief of hematology/oncology at the U-M Medical School.

Researchers looked for 14 different gene mutations in 754 men age 56 and younger with prostate cancer. The men were enrolled in the Prostate Cancer Genetics Project at U-M. Researchers also looked at 1,163 older men with prostate cancer and 2,713 men without prostate cancer.

The study, which was presented at the American Society of Clinical Oncology annual meeting, found that the younger men carried more of these genetic mutations. In addition, 30 percent of the younger men had aggressive prostate cancer and 41 percent of these men had at least one first-degree relative with prostate cancer.

"Early onset prostate cancer has a strong genetic component, which we saw in this study. The genetic variants we looked at here are likely not the best indicators. Our next step is to look more widely for common genetic variants among this group of men," Cooney says.


Contact: Nicole Fawcett
University of Michigan Health System

Page: 1

Related medicine news :

1. MSU researchers discover potential genetic factor in eating disorders
2. Jews Around the World Linked by Common Genetic Ancestry
3. Sun-induced skin cancer: new discovery permits doctors to assess genetic risk
4. Lifestyle Doesnt Influence Genetic Risks in Breast Cancer
5. Genetic differences may influence joint pain among women taking lifesaving breast cancer drugs
6. Genetic data added to archaeology and linguistics to get picture of African population history
7. Fat in Males, Females Differs Genetically, Mouse Study Shows
8. Scientists Map Genetic Codes of Human Microbes
9. Existence Genetics is Pioneering the Field of Predictive Medicine - Nexus Technologies Critical in Understanding and Preventing Deadly Disease
10. Mayo Clinic researchers find genetic secrets to common kidney cancer
11. Genetics of childrens brain tumor unlocked
Post Your Comments:
(Date:11/24/2015)... ... November 24, 2015 , ... Dehydration, defined as a loss ... to perspiration in the hot sun, and heat stroke and death will quickly follow. ... radio host Sharon Kleyne. Every cell, system and structure requires water to function properly. ...
(Date:11/24/2015)... ... 2015 , ... “I am so thrilled, as a newbie here, to leave a mark for ... $7,500 School Lounge Makeover® from California Casualty . Stephanie is in her fifth year ... much longer tenure. , “This is such an amazing school and we deserve a space ...
(Date:11/24/2015)... ... November 24, 2015 , ... ... and safety labels , has been featured in the American Feed ... exclusively to representing the business, legislative and regulatory interests of the U.S. animal ...
(Date:11/24/2015)... ... ... Add a fresh touch to this year’s holiday festivities with indoor plants ... style and cheer to any space. , Holiday plants are more than just festive ... all year long. , “Holiday plants make a room come alive,” says Justin Hancock, ...
(Date:11/24/2015)... ... , ... On the pleasant autumn morning of November 15, 2015, nearly 130 ... for Autism held at Steep Rock Preserve in Washington, Connecticut. The run, which offers ... triumph. , Created and hosted by The Glenholme School, a special needs boarding and ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... 24, 2015 Teledyne DALSA , a Teledyne ... technology, will introduce its CMOS X-Ray detector for mammography ... 29 to December 3, at McCormick Place in ... diagnostic and interventional imaging will be on display in the ... of advanced CMOS X-Ray detectors is the industry benchmark for ...
(Date:11/24/2015)... , Nov. 24, 2015  Enova Illumination is ... of Helsinki, Finland to combine ... are at the cutting edge of medical visualization: Enova ... the United States and Novocam ... Together, they provide the world,s most powerful battery-operated LED ...
(Date:11/24/2015)... Nov. 24, 2015  Freudenberg Medical has developed specialty tubing ... outside of medical facilities. Africa ... care is sparse. Nevertheless, prompt diagnosis is important to treat ... the virus. With the help of a portable mini-lab or ... to village in affected areas and perform rapid testing for ...
Breaking Medicine Technology: