Navigation Links
Genetic marker may predict smoking quantity in African Americans
Date:5/22/2012

In a step toward understanding possible genetic differences in smoking behaviors, a team of researchers co-led by SRI International has identified a genetic marker associated with smoking quantity in people of African ancestry. The study's findings may help guide future public health decisions related to smoking, because the more people smoke, the higher their risk of lung cancer.

The genetic variant, called rs2036527, appears to function as a marker of smoking quantity in African Americans, predicting the number of cigarettes smoked per day. It is on the same nicotine receptor gene, located on Chromosome 15, as another marker previously identified in people of European descent. Earlier studies have also shown that this gene plays a role in limiting nicotine intake by affecting how pleasurable nicotine is, which in turn affects how much nicotine is consumed.

Findings from the Study of Tobacco Use in Minority Populations (STOMP) Genetics Consortium study are published in the May 22, 2012 issue of Translational Psychiatry (part of Nature Publishing Group).

To find the genetic variants for smoking behavior, researchers combined 13 genome-wide association studies. The result included data for genetics and smoking behavior for more than 32,000 African Americans.

Although African Americans are less likely to smoke than European Americans, if they do start smoking, they tend to start smoking later in life, are less likely to quit smoking, and die more often from smoking-related lung cancer. Smoking is the leading cause of premature death among African Americans. STOMP investigators did not assess lung cancer risk, but other researchers have found that the genetic marker (rs2036527) is associated with risk of lung cancer in African Americans.

"This study may have implications for personalized medicine and the need to identify targets for drug discovery." said Sean P. David, M.D., D.Phil., research physician and director of the Translational Medicine program in the Center for Health Sciences in SRI's Policy Division and also a family medicine physician and Clinical Associate Professor of Medicine at Stanford University School of Medicine. "However, we need to be careful not to draw conclusions about the degree to which a genetic variant associated with smoking quantity affects smoker's ability to quit. Future studies of smoking behavior, including smoking cessation clinical trials, should be performed in non-European ancestry groups, so that other informative biomarkers aren't missed."


'/>"/>
Contact: Dina Basin
dina.basin@sri.com
650-862-1657
SRI International
Source:Eurekalert

Related medicine news :

1. Optogenetics project takes top NIDA Addiction Science Award
2. Genetic test identifies eye cancer tumors likely to spread
3. Molecular subtypes and genetic alterations may determine response to lung cancer therapy
4. Genetic predictor of breast cancer response to chemotherapy
5. Advanced genetic screening method may speed vaccine development
6. Genetic abnormalities in benign or malignant tissues predict relapse of prostate cancer
7. Some women may be genetically predisposed to smoking-related hot flashes
8. Genetically modified T cell therapy shown to be safe, lasting in decade-long study of HIV patients
9. Moffitt researcher awarded GE grant to develop tool to detect breast cancer metastasis genetic risks
10. Research Gets Closer to Genetic Roots of Glaucoma
11. Genetic variants, tobacco exposure and lung cancer risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... (PRWEB) , ... June 27, 2016 , ... Quality metrics ... yet in many ways they remain in the eye of the beholder, according to ... a publication of The American Journal of Managed Care. For the full issue, ...
(Date:6/26/2016)... Michigan (PRWEB) , ... June 26, 2016 , ... ... to fertility once they have been diagnosed with endometriosis. These women need a ... they also require a comprehensive approach that can help for preservation of fertility ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency Room , ... Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm facility. , ... our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director of First ...
(Date:6/24/2016)... ... , ... A recent article published June 14 on E Online ... on to state that individuals are now more comfortable seeking to undergo not only ... calf and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians (BHP) ...
(Date:6/24/2016)... ... 24, 2016 , ... Global law firm Greenberg Traurig, P.A. announced that 20 ... by their peers for this recognition are considered among the top 2 percent of ... honors as members of this year’s Legal Elite Hall of Fame: Miami Shareholders ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... -- Dehaier Medical Systems Ltd. (NASDAQ: DHRM ... sells medical devices and wearable sleep respiratory products in ... agreement with Hongyuan Supply Chain Management Co., Ltd. (hereinafter ... 2016, to develop Dehaier,s new Internet medical technology business. ... leverage Hongyuan Supply Chain,s sales platform to reach Dehaier,s ...
(Date:6/24/2016)... , Belgium , June 24, ... VNRX), today announced the appointment of Dr. ... Directors as a Non-Executive Director, effective June 23, ... Audit, Compensation and Nominations and Governance Committees.  As ... Futcher will provide independent expertise and strategic counsel ...
(Date:6/23/2016)... , June 23, 2016 Research ... "Pharmaceutical Excipients Market by Type (Organic Chemical (Sugar, Petrochemical, ... (Oral, Topical, Coating, Parenteral) - Global Forecast to 2021" ... The global pharmaceutical excipients market is ... a CAGR of 6.1% in the forecast period 2016 ...
Breaking Medicine Technology: