Navigation Links
Genetic marker may predict smoking quantity in African Americans
Date:5/22/2012

In a step toward understanding possible genetic differences in smoking behaviors, a team of researchers co-led by SRI International has identified a genetic marker associated with smoking quantity in people of African ancestry. The study's findings may help guide future public health decisions related to smoking, because the more people smoke, the higher their risk of lung cancer.

The genetic variant, called rs2036527, appears to function as a marker of smoking quantity in African Americans, predicting the number of cigarettes smoked per day. It is on the same nicotine receptor gene, located on Chromosome 15, as another marker previously identified in people of European descent. Earlier studies have also shown that this gene plays a role in limiting nicotine intake by affecting how pleasurable nicotine is, which in turn affects how much nicotine is consumed.

Findings from the Study of Tobacco Use in Minority Populations (STOMP) Genetics Consortium study are published in the May 22, 2012 issue of Translational Psychiatry (part of Nature Publishing Group).

To find the genetic variants for smoking behavior, researchers combined 13 genome-wide association studies. The result included data for genetics and smoking behavior for more than 32,000 African Americans.

Although African Americans are less likely to smoke than European Americans, if they do start smoking, they tend to start smoking later in life, are less likely to quit smoking, and die more often from smoking-related lung cancer. Smoking is the leading cause of premature death among African Americans. STOMP investigators did not assess lung cancer risk, but other researchers have found that the genetic marker (rs2036527) is associated with risk of lung cancer in African Americans.

"This study may have implications for personalized medicine and the need to identify targets for drug discovery." said Sean P. David, M.D., D.Phil., research physician and director of the Translational Medicine program in the Center for Health Sciences in SRI's Policy Division and also a family medicine physician and Clinical Associate Professor of Medicine at Stanford University School of Medicine. "However, we need to be careful not to draw conclusions about the degree to which a genetic variant associated with smoking quantity affects smoker's ability to quit. Future studies of smoking behavior, including smoking cessation clinical trials, should be performed in non-European ancestry groups, so that other informative biomarkers aren't missed."


'/>"/>
Contact: Dina Basin
dina.basin@sri.com
650-862-1657
SRI International
Source:Eurekalert

Related medicine news :

1. Optogenetics project takes top NIDA Addiction Science Award
2. Genetic test identifies eye cancer tumors likely to spread
3. Molecular subtypes and genetic alterations may determine response to lung cancer therapy
4. Genetic predictor of breast cancer response to chemotherapy
5. Advanced genetic screening method may speed vaccine development
6. Genetic abnormalities in benign or malignant tissues predict relapse of prostate cancer
7. Some women may be genetically predisposed to smoking-related hot flashes
8. Genetically modified T cell therapy shown to be safe, lasting in decade-long study of HIV patients
9. Moffitt researcher awarded GE grant to develop tool to detect breast cancer metastasis genetic risks
10. Research Gets Closer to Genetic Roots of Glaucoma
11. Genetic variants, tobacco exposure and lung cancer risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton Lakes ... a mock evacuation of the facility as part of a disaster drill on October ... Hose EMS and Shelton City Emergency Manager, as well as the Connecticut Long ...
(Date:10/13/2017)... ... 2017 , ... Ellevate Network, the leading network for professional women, brought together ... equality at their inaugural Summit in New York City in June. The event was ... of over 3 million. To watch the Mobilize Women video, click here . ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented host, actor Rob Lowe, ... in a new episode of "Success Files," which is an award-winning educational program ... investigates each subject in-depth with passion and integrity. , Sciatica occurs when the ...
(Date:10/13/2017)... ... ... “America On The Brink”: the Christian history of the United States and the loss ... author, William Nowers. Captain Nowers and his wife, Millie, have six children, ten ... the Navy. Following his career as a naval aviator and carrier pilot, he ...
(Date:10/12/2017)... , ... October 12, 2017 , ... Planet Fitness, one ... U.S., announced today its plans to open a flagship location in Covington, LA at ... former Rooms To Go store next to Office Depot in the Holiday Square shopping ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... Oct. 4, 2017  South Korean-based healthcare product Development ... aide "cprCUBE" on Kickstarter. The device will educate the ... arrests with better efficiency compared to the dated and ... feedback on efficacy of the compression for a more ... a goal to raise $5,000. ...
(Date:10/2/2017)... Oct. 2, 2017  AllianceRx Walgreens Prime, the combined ... Walgreens and pharmacy benefit manager Prime Therapeutics LLC (Prime), ... which included the unveiling of new signage at its ... well as at a few other company-owned facilities across ... to patients, some of whom will begin to see ...
(Date:9/27/2017)... their devotion to personalized service, SMP Pharmacy Solutions announces their ... South Florida Business Journal,s 50 Fastest-Growing Companies, and listed for ... specialty pharmacy has found its niche.  To that end, the ... by SFBJ as the 2017 Power Leader in Health Care. ... award in October, Bardisa said of the three achievements, "It,s ...
Breaking Medicine Technology: