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Genetic map of African-Americans to aid study of diseases, human evolution
Date:7/20/2011

analyzing genetic data to reconstruct the mosaic of regions of African and European genetic ancestry in DNA of modern African-Americans.

Using a computer program Reich and Myers wrote specifically to sort the massive amounts of data, Hinch identified places in the genomes of the 30,000 people where switches occurred between African and European ancestry, detecting about 70 per person. These switches correspond to recombination events in the last couple of hundred years, resulting in the more than 2 million recombination events that the researchers used to build the map.

The study was only possible because of collaboration from 81 co-authors from many institutions, using DNA samples from five large studies that had previously been carried out to study common diseases such as heart disease and cancer, funded by the National Institutes of Health, the Department of Defense, and many private foundations.

"All the co-authors worked together in an incredibly collegial way to put together the enormous set of samples and high quality genetic data that made this study a success," Wilson said.


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Contact: Jack Mazurak
jmazurak@umc.edu
601-984-1970
University of Mississippi Medical Center
Source:Eurekalert

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