Navigation Links
Genetic link between pancreatitis and alcohol consumption, says Pitt team
Date:11/12/2012

PITTSBURGH, Nov. 12, 2012 A new study published online today in Nature Genetics reveals a genetic link between chronic pancreatitis and alcohol consumption. Researchers from the University of Pittsburgh School of Medicine and more than 25 other health centers across the United States found a genetic variant on chromosome X near the claudin-2 gene (CLDN2) that predicts which men who are heavy drinkers are at high risk of developing chronic pancreatitis. This finding enables doctors to identify people with early signs of pancreatitis or an attack of acute pancreatitis who are at very high risk for progressing to chronic pancreatitis, allowing them to take preventative action to slow the development of the disease, and give the pancreas a chance to heal. Once an individual develops pancreatitis it takes several years for the pancreas to deteriorate.

"The discovery that chronic pancreatitis has a genetic basis solves a major mystery about why some people develop chronic pancreatitis and others do not," said David C. Whitcomb, M.D., professor of medicine, cell biology and physiology, and human genetics at the University of Pittsburgh School of Medicine and lead author of the report. "We also knew there was an unexpected higher risk of men developing pancreatitis with alcohol consumption, but until now we weren't sure why. Our discovery of this new genetic variant on chromosome X helps explain this mystery as well."

Over 100,000 Americans suffer from chronic pancreatitis, a progressive inflammatory disease characterized by abdominal pain and permanent damage to the pancreas. Most studies report excessive alcohol consumption as the major risk factor for adult-onset chronic pancreatitis. However, according to Dr. Whitcomb, who also is chief of the Division of Gastroenterology, Hepatology and Nutrition, only 3 percent of individuals who are alcoholics develop chronic pancreatitis, suggesting a pancreas-specific risk factor.

The study was conduc
'/>"/>

Contact: Cristina Mestre
MestreCA@upmc.edu
412-586-9776
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Wake Forest Baptist research goes global with genetic center in India
2. Molecular Genetics & Genomic Medicine: New open access journal launched by Wiley
3. New light on the genetic basis of inflammatory diseases
4. Genetic test results for Lynch syndrome improved with new computer program
5. IU researchers report first effective treatment of tumors arising from common genetic disease NF1
6. Smoking and hyperactivity share common genetic risk factor
7. Moffitt Researchers find genetic predictors of fatigue for some prostate cancer patients
8. CWRUs Maxwell J. Mehlmans book examines issues emerging in genetic engineering
9. Genetically-engineered preclinical models predict pharmacodynamic response
10. Scientists Map Genetic Blueprint of Heart
11. Epigenetics emerges powerfully as a clinical tool
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2015)... 02, 2015 ProvidaStaff has ... its educational healthcare division to EDU Healthcare ... services to school systems and students nationwide. , “ProvidaStaff ... school districts throughout the country,” said Angela M. Lewis, ... a better organization and the introduction of EDU Healthcare ...
(Date:3/2/2015)... 02, 2015 Final Cut Pro X ... Volume 2 from Pixel Film Studios. , “The TranStatic Volume ... FCPX,” said Christina Austin, CEO of Pixel Film Studios. “TranStatic ... Final Cut Pro X editors toolbox.” , With TranStatic Volume ... with media altering static scrambling effects from Pixel Film Studios. ...
(Date:3/1/2015)... Clearwater, Florida (PRWEB) March 02, 2015 ... market their services and manage their practices ... offer an integrated all-inclusive solution. The ... development program and a medical practice management ... success and long-term financial sustainability. A referral ...
(Date:3/1/2015)... As residents and business owners in Southlake, Texas, ... Weaver, believe in supporting local organizations and causes. ... of Commerce, Carroll Independent School District and numerous ... for Southlake mayoral candidate Laura Hill: http://www.LauraHillforSouthlake.com ... campaign, the website combines images, videos and interactive ...
(Date:3/1/2015)... Birmingham, Clarkston, Lake Orion, Metamora, Michigan (PRWEB) March 01, 2015 ... BOTOX® , which is approved to treat Overactive Bladder (OAB) ... urgency and frequency in adults when another type of medication ... This is a different treatment option that takes another ... itself. , BOTOX® works on the nerves and ...
Breaking Medicine News(10 mins):Health News:ProvidaStaff Announces New Name Change to EDU Healthcare for Its Educational Healthcare Division 2Health News:ProvidaStaff Announces New Name Change to EDU Healthcare for Its Educational Healthcare Division 3Health News:Pixel Film Studios released the TranStatic Volume 2 plugin for Final Cut Pro X today 2Health News:Power Up Physician and Patient Referral Management While Qualifying for ARRA Incentives 2Health News:Power Up Physician and Patient Referral Management While Qualifying for ARRA Incentives 3Health News:Power Up Physician and Patient Referral Management While Qualifying for ARRA Incentives 4Health News:Website Launched for Southlake, Texas Mayoral Candidate Laura Hill 2Health News:Women's Excellence Now Offers BOTOX For Overactive Bladder Treatment 2
... New England Journal of Medicine reports the latest research ... crossed in treating early breast //cancer successfully after having ... studies apparently looked into the effectiveness of adding the ... in early stages of breast cancer. Both studies ...
... Breast Cancer Campaign charity yesterday suggested that breast cancer may ... a long-term manageable disorder like diabetes and arthritis. ... to the significant developments in the diagnosis and treatment of ... recurrence of the cancer was reduced by new drugs like ...
... less inclined to commit suicide as compared to Whites was ... among black Americans. Scientists from the University of Michigan said ... ones own life happens to be the 11th leading cause ... that nearly one in 10 black Americans suffer from suicidal ...
... of coffee (3 cups a day) can affect a man's ... to show the adverse effect of modern life on the ... the US govt. has shown that modern men have only ... hampster (160 million/ml). The sperm count has declined worldwide over ...
... More than two-thirds of people who suffer from major ... work with their doctors //and try various treatments to ... taking different antidepressants or adding cognitive therapy to the ... led by UT Southwestern Medical Center, found that 67 ...
... According to British scientists, symptoms of schizophrenia can be ... Imperial College London conducted a study in 4 hospitals ... when they were encouraged to express themselves through music. ... psychological treatments can help people with schizophrenia, but these ...
Cached Medicine News:Health News:Breast Cancer may no longer be a killer disease 2Health News:Carefully Monitored Treatment Can Help Those Who Suffer from Depression 2Health News:Carefully Monitored Treatment Can Help Those Who Suffer from Depression 3
(Date:2/27/2015)... 27, 2015 /CNW/ - Covalon Technologies Ltd. (the "Company" or ... announced financial results for its first quarter ended December ... ended December 31, 2014, revenue was $1,336,685. Operating expenses ... or $0.02 per share.  Covalon,s President ... very pleased with the significant progress we have made ...
(Date:2/27/2015)... SAN DIEGO , Feb. 27, 2015 /PRNewswire/ ... three-dimensional biology company focused on delivering breakthrough 3D ... , President and Chief Executive Officer, will present ... "We invite you to join us for ... to provide updates on our commercial launch of ...
(Date:2/27/2015)... MINNEAPOLIS , Feb. 27, 2015  Uroplasty, Inc. (NASDAQ: ... develops, manufactures and markets innovative proprietary products to treat ... the 27th Annual ROTH Conference on Tuesday, March 10, ... Brett Reynolds , Chief Financial Officer, will present ... one on one at the conference at the Ritz ...
Breaking Medicine Technology:Covalon Announces First Quarter Financial Results 2Covalon Announces First Quarter Financial Results 3Organovo Holdings, Inc. to Provide Corporate Update and Investor Presentation in a Live, Interactive Webcast on March 5th 2Organovo Holdings, Inc. to Provide Corporate Update and Investor Presentation in a Live, Interactive Webcast on March 5th 3Organovo Holdings, Inc. to Provide Corporate Update and Investor Presentation in a Live, Interactive Webcast on March 5th 4Uroplasty to Participate in the 27th Annual ROTH Conference 2
... Technology is revolutionizing healthcare — making it more ... cost of care. AT&T ,s* new set of ... designed to do just that. The 2011 Frost & ... AT&T for its approach to mHealth, recognizing the company,s ...
... -- GC-Rise Pharmaceutical Co. Ltd, in which European healthcare ... recently listed as one of the Deloitte & Touche,s ... growth over the past three years. Beijing-headquartered ... its operating revenues rising more than 270% on average ...
Cached Medicine Technology:Frost and Sullivan Recognizes AT&T's Innovative mHealth Strategy 2Frost and Sullivan Recognizes AT&T's Innovative mHealth Strategy 3Frost and Sullivan Recognizes AT&T's Innovative mHealth Strategy 4Women Health Expert GC-Rise Listed in Deloitte's 50 Top-performing Companies 2
... Bausch & Lomb PreserVision® AREDS formula ... and mineral supplement clinically proven effective in ... Age Related Eye Disease Study (AREDS). , ... and mineral supplement with the antioxidant vitamins ...
Ocuvite® vitamin and mineral supplements contain 2 mg of Lutein 8 times more than the leading multivitamins. Ocuvite also contains vitamin antioxidants A, C and E, as well as the minerals zinc, ...
HydroEye is an exclusive formulation designed to provide dry eye relief and support the body's natural tear formation. Like all ScienceBased Health formulations, it is produced in softgel form for ma...
Easy-to-use desktop QC data management solution...
Medicine Products: