Navigation Links
Genetic interactions are the key to understanding complex traits
Date:1/22/2009

lled sporulation. Cohen acknowledges it's not a particularly fascinating trait, but it is one that can be measured easily and precisely.

"We don't have any particular fondness for sporulation," he says. "We are simply using it as a model to understand how multiple genes interact to influence variation in a biological process. Our hope is that a complex trait is put together in yeast in a similar way as it is in humans."

When it comes to sporulation, the yeast from the oak tree samples produce spores with 99 percent efficiency; the vineyard strains are far less efficient, at seven percent.

The scientists discovered that just four variants, or single nucleotide polymorphisms (SNPs), in three yeast genes account for nearly 90 percent of the genetic contribution to sporulation efficiency. By moving each of the four variants from one yeast strain to the other, they produced oak strains that sporulated like vineyard strains and vice versa.

"To put this into context, there are about 85,000 SNP differences between the two strains of yeast, and by moving just four of them, we effectively reversed the phenotype of the two strains," Cohen says.

The researchers also exchanged every combination of the four SNPs between the yeast strains to determine how the genetic variations interacted. Interestingly, any two or more of variants from the oak tree strain increased sporulation efficiency far more than would have been expected based on the individual contributions of each SNP.

"The variations interacted like crazy," Cohen says. "The combined effects of variants were always larger than the sum of their individual effects."

Understanding these interactions was critical for the scientists to accurately predict how a strain would behave based on the variations it carries in its genome. Only by accounting for the interactions between variants could they predict how particular variants combine to increase or decrease
'/>"/>

Contact: Caroline Arbanas
arbanasc@wustl.edu
314-286-0109
Washington University School of Medicine
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. The 2009 Damon Runyon-Rachleff Innovation Award Granted for Pioneering Ideas for Early Detection of Ovarian and Lung Cancers, Bone Marrow Transplant Safety, and Discovery of New Genetic Markers for Cancer
2. Interleukin Genetics to Present Data Highlighting Link Between Inflammatory Gene Variations and Less Effective Weightloss
3. Genetic Data May Not Boost Heart Disease Predictions
4. Genetic Data May Predict Colon Cancer Odds
5. FDA Issues Final Regulations for Genetically Engineered Animals
6. UT leads $2.5 million training program in pioneering area of genetic research
7. Identification of genetic markers for ulcerative colitis could lead to treatment
8. CellCyte Genetics Corporation: Seattle Times Erroneously Reports That CellCyte Closes
9. Beta Release of a New Genetics Website- ItRunsInMyFamily.com
10. New Genetic Analysis Might Boost Breast Cancer Care
11. Genetic Variants Tied to Obesity
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genetic interactions are the key to understanding complex traits
(Date:8/28/2015)... ... , ... The Kentucky State Department of Workforce Investment Commissioner Beth Kuhn recently ... for, they are unable to pass the initial drug test and therefore unable to ... order to be able to hire long-term, skilled talent. (1) Will Wesch, Director of ...
(Date:8/28/2015)... ... August 28, 2015 , ... For Dallas, the time is nearing for the ... USPI Tenet Health. , The American Heart Association hosts their well-known Heart Walk to ... that together, a difference can be made. Walkers can participate in the cause and ...
(Date:8/28/2015)... ... August 28, 2015 , ... The 6th Annual Survivor in the City, ... added yet another accolade to its cadre of widespread support—an official letter of support ... help of the medical community and the University of Illinois at Chicago’s Department of ...
(Date:8/28/2015)... ... August 28, 2015 , ... Saint Petersburg, FL ... with zero fat, carbs, sugar, gluten, lactose or caffeine in a convenient 2 ... 2015 SupplySide CPG Editor’s Choice Awards. , Five consumer packaged goods (CPG) products ...
(Date:8/28/2015)... (PRWEB) , ... August 28, 2015 , ... ... businesses nationwide. Addictions specialist, Dr. James Strawbridge, gives a new approach on solutions ... it should begin with the employer and employees getting together for meaningful group ...
Breaking Medicine News(10 mins):Health News:Hiring Obstacles: Drug Abuse a Problem for Workforce 2Health News:Hiring Obstacles: Drug Abuse a Problem for Workforce 3Health News:Hiring Obstacles: Drug Abuse a Problem for Workforce 4Health News:North Central Surgical Center’s Subsidiary Participates in Walk 2Health News:Chicago Mayor Pens Official Support of Annual Survivor in the City Event Benefitting Brain Aneurysm Foundation 2Health News:Chicago Mayor Pens Official Support of Annual Survivor in the City Event Benefitting Brain Aneurysm Foundation 3Health News:Pocket Protein™ Named 2015 CPG Editor’s Choice Award Finalist by Informa’s SupplySide 2Health News:Pocket Protein™ Named 2015 CPG Editor’s Choice Award Finalist by Informa’s SupplySide 3
... could lead to new birth control for men , WEDNESDAY, ... of proteins called PLA2s play a vital role in sperm ... , The findings could improve understanding of male infertility and ... for infertility. , In one study, Japanese researchers found that ...
... ... share the leading position in the European Union’s “Novel Foods” category , ... Provo, UT (Vocus) April 28, 2010 -- ... Commission on Food Safety. Now, not only do noni juice and noni leaf have Novel ...
... ... that more than 100 baby boys die from circumcision complications each year, including from ... deaths are avoidable. , ... (PRWEB) April 28, 2010 -- The International Coalition for Genital Integrity (ICGI) acknowledges ...
... ... elegant celebration of the unique bond between adults and their moms - has been released publicly ... ... A Poem for Mothers - I Honor You " by bestselling author Brian Vaszily has been ...
... ... Brooklyn Bridge Park playground is closed for renovation less than a month after opening. ... New York (PRWEB) April 28, ... down this week. Less than a month after it opened, the much-anticipated playground was declared ...
... ... Develop a 100 Percent Lead Free Bubbler Retrofit Kit , ... Los Angeles, CA (Vocus) April 28, 2010 -- Acorn ... and a division of Acorn Engineering Company, announces a 100 percent lead-free bubbler retrofit kit ...
Cached Medicine News:Health News:Third European Novel Food Approval Received by Tahitian Noni International 2Health News:Children's Rights Group Agrees with New Study: Infant Circumcision Causes 100 Deaths Each Year in US 2Health News:Inspirational Short Video for Adults Who Celebrate Their Mothers Called "A Poem for Mothers" Released on YouTube 2Health News:Inspirational Short Video for Adults Who Celebrate Their Mothers Called "A Poem for Mothers" Released on YouTube 3Health News:New York Personal Injury Lawyer, David Perecman, says New Playground is No Place for Kids 2Health News:New York Personal Injury Lawyer, David Perecman, says New Playground is No Place for Kids 3Health News:The Acorn Aqua's Lead Free Bubbler 2
(Date:8/28/2015)... , Aug. 28, 2015 Perrigo Company plc ... the Mylan N.V. ("Mylan") (NASDAQ: MYL ) shareholder ... "Our views of Mylan,s offer to Perrigo ... based on our Board,s careful reflection of the value ... the limited choices that Mylan has allowed its shareholders ...
(Date:8/28/2015)... Korea , Aug. 28, 2015 ... University and Dr. Ra from Biostar , Published ... Confirmed 30% increase of lifespan through multiple IV administration ... physical vitality, and life expectancy found , Commercialization ... Korea have determined the possibility that adult mesenchymal stem ...
(Date:8/28/2015)... August 28, 2015 The global ... USD 49.12 billion by 2020, growing at a CAGR ... new report by Grand View Research, Inc. Monitoring services ... 49.7% from 2014 to 2020.      (Logo: ... along with rising incidences of chronic diseases such as ...
Breaking Medicine Technology:Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 2Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 3Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 4Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 5Korean Researchers Find the Possibility that Adult Mesenchymal Stem Cells (MSCs) May Extend Lifespan 2mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 2mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 3mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 4mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 5
... protection Properly manufactured radiation protective eyewear ... Our high quality frames and materials offer ... weight. Our lenses are made of Schott ... industry standards. Most Pulse Glasses are offered ...
Uvex Patriot Frame...
Panoramic styling that contours closely to the face and brow. Saddle bridge fits average to fuller noses. Adjustable temple hinge adjusts up or down, longer or shorter. Soft cushion behind ear for co...
QualCraft™ Euro Lite has a molded nylon frame that fits most faces. Universal keyhole nose bridge fits narrow to average noses. Available with or without lead vinyl-lined side shields....
Medicine Products: