Navigation Links
Genetic interactions are the key to understanding complex traits
Date:1/22/2009

Jan. 23, 2009 -- In recent years, genetic studies have uncovered hundreds of DNA variations linked to common diseases, such as cancer or diabetes, raising the prospect that scientists can gauge disease risk based on information in an individual's genome. But the variations identified to date only account for a small percentage typically one to three percent of the overall genetic risk of any common disease.

This disappointment has led geneticist Barak Cohen, Ph.D., of Washington University School of Medicine in St. Louis, to suggest that scientists need to get a better handle on the ways genes interact to influence disease risk.

"For diseases that are major health problems, many different genetic variants combine to affect an individual's risk," says Cohen. "The problem is that we as scientists are really lousy at predicting how these variations interact to determine whether an individual is likely to develop a common disease or respond to a particular drug."

This reality begs the question: Is it possible to tease apart a complex genetic trait to reveal the precise genetic variations that have combined to produce it? Yes, Cohen and his group report in the Jan. 23 issue of Science. If the research can be replicated, it suggests that scientists need better statistical models and other tools to understand genetic interactions.

The researchers turned to a simple organism, the yeast Saccharomyces cerevisiae, culled from North American oak trees and vineyards, where it grows naturally, to find their answer.

"This was a test case," Cohen explains. "If we can't dissect a complex genetic trait that occurs naturally in yeast and show how multiple genes interact to produce a particular trait, then there's no hope for doing it in humans."

The researchers probed the genome of yeast to find the DNA variations that determine the efficiency with which the yeast undergo sexual reproduction, a process ca
'/>"/>

Contact: Caroline Arbanas
arbanasc@wustl.edu
314-286-0109
Washington University School of Medicine
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. The 2009 Damon Runyon-Rachleff Innovation Award Granted for Pioneering Ideas for Early Detection of Ovarian and Lung Cancers, Bone Marrow Transplant Safety, and Discovery of New Genetic Markers for Cancer
2. Interleukin Genetics to Present Data Highlighting Link Between Inflammatory Gene Variations and Less Effective Weightloss
3. Genetic Data May Not Boost Heart Disease Predictions
4. Genetic Data May Predict Colon Cancer Odds
5. FDA Issues Final Regulations for Genetically Engineered Animals
6. UT leads $2.5 million training program in pioneering area of genetic research
7. Identification of genetic markers for ulcerative colitis could lead to treatment
8. CellCyte Genetics Corporation: Seattle Times Erroneously Reports That CellCyte Closes
9. Beta Release of a New Genetics Website- ItRunsInMyFamily.com
10. New Genetic Analysis Might Boost Breast Cancer Care
11. Genetic Variants Tied to Obesity
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genetic interactions are the key to understanding complex traits
(Date:3/1/2015)... March 01, 2015 Indiana Fiber ... Service Provider, announces NewWays Networking, LLC (NewWays) selected ... working with IFN, NewWays is well positioned to ... demand for Internet bandwidth in rural parts of ... According to Cory Childs IFN Enterprise Sales Manager, ...
(Date:3/1/2015)... The Barrel Mill ” was featured on NewsWatch as part ... the latest and coolest technology products and services available to ... expert, conducted the review and shared with viewers how this ... Home Distillation of Alcohol, it's understood that oak is essential ... product that’ll help anyone achieve a barrel aged alcohol without ...
(Date:3/1/2015)... (PRWEB) February 28, 2015 CrossFit Attollo is ... they are offering a special discount to new members. ... up for a three month contract will receive their fourth ... individually would cost members $440. The three month contract ... month, and then the fourth month comes in at only ...
(Date:2/28/2015)... 2015 In recent years Medical Marijuana has ... physicians as a way for them to expand their patient ... as medicine. Since the FDA still lists Cannabis as a ... to licensed physicians that can help guide them when ... Malka in Santa Cruz, CA is a leader in ...
(Date:2/28/2015)... OR (PRWEB) February 28, 2015 In ... Duncan Fletcher of Game Change Athlete ... Shannon Leinert about the benefits of athlete development and ... some of the unique challenges that athletes face and ... and future success. , Fletcher became involved in athlete ...
Breaking Medicine News(10 mins):Health News:NewWays Networking Selects Indiana Fiber Network, LLC as Fiber Transport Provider 2Health News:An Oak Infusion Spiral was Featured on NewsWatch Television on January 30, 2015 2Health News:CrossFit Gym in Vancouver WA Offers Spring Special 2Health News:Reputable Cannabis Doctor In Santa Cruz and Monterey Joins the Medical Cannabis Network 2Health News:SCI TV Covers Athlete Development with Duncan Fletcher 2Health News:SCI TV Covers Athlete Development with Duncan Fletcher 3
... DCThe Institute for Health Technology Studies (InHealth) has awarded ... researchers, for a study that will assess the effects ... decisions of older adults. Led by researchers at the ... the University of York (York, UK), and the Johns ...
... -- The number of American adults treated for diabetes more than ... 19 million, says a federal government report released Wednesday. By ... 4.3 million to 8 million among people age 65 and older; ... and 1.2 million to 2.4 million among people aged 18 to ...
... (HealthDay News) -- DNA can be used to determine the ... by police, Dutch researchers report. They found that DNA ... has red hair or black hair, and about 80 percent ... be taken from blood, sperm, saliva or other biological evidence ...
... Sinai School of Medicine has developed the first web-based ... has recently been used by soldiers returning from the ... Sixth Annual Road to Recovery Conference and Tribute in ... "Traumatic brain injury is underdiagnosed, and left untreated ...
... RI When methicillin-resistant S. aureus (MRSA) is ... for an invasive infection, including a surgical site infection. Some ... in the nose, the greater the risk of transmission to ... Few studies to date have assessed the differences in quantity ...
... a much hailed communication intervention works for families making ... units, Case Western Reserve University researchers found the intervention ... Barbara Daly and Sara Douglas, the study,s lead ... at Case Western Reserve, attribute the varied results to ...
Cached Medicine News:Health News:International consortium to examine the impact of medical devices on health and retirement 2Health News:International consortium to examine the impact of medical devices on health and retirement 3Health News:Diabetes Soaring Among American Adults: Report 2Health News:Mount Sinai develops first screening tool for war veterans to assess traumatic brain injury 2Health News:Where MRSA colonizes on the human body 2Health News:ICU communication study reveals complexities of family decision-making 2Health News:ICU communication study reveals complexities of family decision-making 3
(Date:2/27/2015)... , February 27, 2015 ... new study showing you trends, R&D progress, and predicted ... heading? What are the commercial prospects for this ... you potential revenues and other trends to 2025, discussing ... report lets you assess regenerative medicine : cell-based ...
(Date:2/27/2015)... SAN DIEGO , Feb. 27, 2015 /PRNewswire/ ... three-dimensional biology company focused on delivering breakthrough 3D ... , President and Chief Executive Officer, will present ... "We invite you to join us for ... to provide updates on our commercial launch of ...
(Date:2/27/2015)... Feb. 27, 2015  Two mass spectrometry ... applications as their effectiveness is established, according ...  Kalorama Information says that while mass spectrometry ... powerful tool in proteomic biomarker discovery and ... its traditional techniques has struggled to elucidate ...
Breaking Medicine Technology:Translational Regenerative Medicine: Market Prospects 2015-2025 2Translational Regenerative Medicine: Market Prospects 2015-2025 3Translational Regenerative Medicine: Market Prospects 2015-2025 4Translational Regenerative Medicine: Market Prospects 2015-2025 5Translational Regenerative Medicine: Market Prospects 2015-2025 6Translational Regenerative Medicine: Market Prospects 2015-2025 7Translational Regenerative Medicine: Market Prospects 2015-2025 8Organovo Holdings, Inc. to Provide Corporate Update and Investor Presentation in a Live, Interactive Webcast on March 5th 2Organovo Holdings, Inc. to Provide Corporate Update and Investor Presentation in a Live, Interactive Webcast on March 5th 3Organovo Holdings, Inc. to Provide Corporate Update and Investor Presentation in a Live, Interactive Webcast on March 5th 4Report: "Softer" Mass Spec Techniques Gaining Popularity in Biomarker Discovery 2Report: "Softer" Mass Spec Techniques Gaining Popularity in Biomarker Discovery 3
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: