Navigation Links
Genetic flaw in males triggers onset of liver cancer, diabetes
Date:12/9/2013

Michigan State University researchers have uncovered a genetic deficiency in males that can trigger the development of one of the most common types of liver cancer and forms of diabetes.

The research, published in the online issue of Cancer Cell, found that when the NCOA5 gene, present in both men and women, was altered in male mice to a deficient level, a spontaneous reaction occurred producing cells that can lead to hepatocellular carcinoma, a type of liver cancer found to be two-to-four times more prevalent in men than women.

Findings also showed that prior to cancer development there were occurrences of glucose intolerance, a prediabetic condition that is believed to increase the risk of type 2 diabetes in humans. Conversely, the study showed female mice did not develop these diseases.

"Essentially, what this provides is evidence for a genetic susceptibility in males to this particular type of liver cancer and diabetes," said Hua Xiao, lead researcher of the project and associate professor of physiology in MSU's College of Human Medicine. "Ninety-four percent of the male mice we looked at developed the liver cancer, while 100 percent of these mice developed glucose intolerance."

Xiao notes the reason for the distinct outcomes between males and females also may have to do with the different levels of hormones between genders.

"Because estrogen may function through the NCOA5 gene and previously has been found to play somewhat of a protective role against both diseases, the result is a decreased risk in females," he said. "Since males produce lower amounts of estrogen, this can contribute to their susceptibility."

Type 2 diabetes has been widely associated with liver cancer as a common risk factor. Yet due to the increasing prevalence of diabetes worldwide and the limited treatments for hepatocellular carcinoma, this research could open the door to new therapeutic options.

"At this point, it's not known if the genetic deficiency can be reversed and needs to be investigated further," Xiao said. "But if it can somehow be changed through treatments such as drug therapies, this could substantially increase the chances of men in particular warding off these diseases."


'/>"/>

Contact: Sarina Gleason
sarina.gleason@cabs.msu.edu
517-355-9742
Michigan State University
Source:Eurekalert  

Related medicine news :

1. IntegraGen launches ARISk test, a genetic screening tool for autism in high-risk children
2. 2 genetic deletions in human genome linked to the development of aggressive prostate cancer
3. Head, Body Lice Are Genetically Very Similar
4. Certain Genetic Regions May Be Tied to Osteoporosis
5. Study of half siblings provides genetic clues to autism
6. Genetic variants, tobacco exposure and lung cancer risk
7. Research Gets Closer to Genetic Roots of Glaucoma
8. Moffitt researcher awarded GE grant to develop tool to detect breast cancer metastasis genetic risks
9. Genetically modified T cell therapy shown to be safe, lasting in decade-long study of HIV patients
10. Some women may be genetically predisposed to smoking-related hot flashes
11. Genetic abnormalities in benign or malignant tissues predict relapse of prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genetic flaw in males triggers onset of liver cancer, diabetes
(Date:10/13/2017)... ... , ... Apple Rehab Shelton Lakes , which specializes in the delivery ... as part of a disaster drill on October 3rd. , Apple Rehab participated with ... Manager, as well as the Connecticut Long Term Care Mutual Aid Plan (LTC-MAP). ...
(Date:10/13/2017)... ... ... Ellevate Network, the leading network for professional women, brought together some of ... their inaugural Summit in New York City in June. The event was livestreamed with ... 3 million. To watch the Mobilize Women video, click here . , ...
(Date:10/13/2017)... ... , ... Talented host, actor Rob Lowe, is introducing a ... episode of "Success Files," which is an award-winning educational program broadcasted on PBS ... in-depth with passion and integrity. , Sciatica occurs when the sciatic nerve in ...
(Date:10/13/2017)... ... ... “America On The Brink”: the Christian history of the United States and the loss ... author, William Nowers. Captain Nowers and his wife, Millie, have six children, ten ... the Navy. Following his career as a naval aviator and carrier pilot, he ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and ... plans to open a flagship location in Covington, LA at 401 N. U.S. Highway ... store next to Office Depot in the Holiday Square shopping center. Its location allows ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... AVACEN Medical , Inc. (AVACEN) announced that ... New Product Innovation Award for Its fibromyalgia pain management ... medical device market research by Frost & Sullivan,s industry experts. ... pain relief product, the AVACEN 100, offers a safe and ... pain. ...
(Date:10/11/2017)... Oct. 11, 2017  True Health, a leader ... its effort during National Breast Cancer Awareness month ... risks. Research ... calculated that more than 10 million American women ... in BRCA1 or BRCA2 and have not had testing. ...
(Date:10/5/2017)... 5, 2017  In response to the nationwide ... Maxillofacial Surgeons (AAOMS) released prescribing recommendations that urge ... used as a first-line therapy to manage a ... Recognizing the value and importance ... "Opioid Prescribing: Acute and Postoperative Pain Management" stresses ...
Breaking Medicine Technology: