Navigation Links
Genetic factors behind high blood pressure
Date:9/20/2011

High blood pressure is a well-known risk factor for heart disease. Researchers at the Sahlgrenska Academy at the University of Gothenburg, Sweden, have participated in an international study of 200,000 Europeans which has identified 16 new genetic variations that affect blood pressure. The discovery, presented in Nature, is an important step towards better diagnostics and treatment.

A billion people worldwide suffer from high blood pressure and are therefore in the danger zone for the likes of heart disease and stroke. Effective prediction and control of high blood pressure is therefore one of the most pressing global health issues.

Analyzing genetic data

Researchers from the Sahlgrenska Academy at the University of Gothenburg are among an international consortium of more than 400 researchers from the US, Europe, Asia and Australia hoping to identify which parts of our genes influence blood pressure by sifting through vast quantities of genetic data.

2.5 million DNA variations

In their latest study, the researchers analysed more than 2.5 million DNA variations from more than 200,000 Europeans. The results, published in the renowned journal Nature, reveal 16 previously unknown genetic regions with interesting genes that regulate the body's blood pressure both the lower level when the heart expands (diastolic) and the upper level when the heart contracts (systolic).

Genetic risk groups

With the help of these newly discovered genetic variations, the researchers have constructed genetic risk groups to help predict the risk of strokes and heart attacks.

"We've been able to classify individuals on the basis of how many risk variants for hypertension they have in their genes" says Fredrik Nyberg, a researcher from the Sahlgrenska Academy working on the project.

Important step forward

In another study published at the same time in Nature Genetics, the researchers from Gothenburg identify additional new genetic regions and genes controlling two other measures of blood pressure: pulse pressure (the difference between systolic and diastolic) and mean arterial pressure (an average of systolic and diastolic). The study shows how important it is to analyse different measures of blood pressure. For example, pulse pressure is a marker of rigidity in the arteries carrying blood from the heart to the body, and different genes seem to control different aspects of blood pressure.

The results of the two studies are considered to be an important step towards understanding how the body regulates blood pressure, and the newly discovered genetic regions are potential targets for future treatments.


'/>"/>

Contact: Fredrik Nyberg
fredrik.nyberg@amm.gu.se
46-031-786-6289
University of Gothenburg
Source:Eurekalert  

Related medicine news :

1. Certain genetic profiles associated with recurrence-free survival for non-small cell lung cancer
2. Obstructive Sleep Apnea in Kids May Have Genetic Cause
3. Epigenetic signals differ across alleles
4. Study reveals genetic link between mammographic density and breast cancer
5. Genetic Risk Score Doesnt Spot Heart Trouble in Women
6. Penn researchers find genetic link to leukemias with an unknown origin
7. Scientists Spot Genetic Fingerprints of Individual Cancers
8. Genetic health risks in children of assisted reproductive technology
9. Genetic Mutation Linked to Prostate Cancer in Blacks
10. Protecting the brain from of a deadly genetic disease
11. Protecting the brain from a deadly genetic disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genetic factors behind high blood pressure
(Date:3/24/2017)... Oakland, CA (PRWEB) , ... March 24, 2017 ... ... present on two panels at the Advanced ERISA Benefit Claims Litigation seminar in ... and Creating the Administrative Record, The majority of cases litigated under ERISA involve ...
(Date:3/24/2017)... , ... March 24, 2017 , ... ... first Certified Medical Reiki™ Master in Frederick, MD. Judy says, “I am passionate ... during what is often a very difficult and challenging time.” , A Certified ...
(Date:3/24/2017)... ... March 24, 2017 , ... “The Adventures of Joey, The Dog Who Barks ... lives his life to the fullest, as God intended. “The Adventures of Joey, The ... mother and grandmother pursuing her passion for writing, especially about truth and human behavior. ...
(Date:3/23/2017)... ... March 23, 2017 , ... Texas Physical Therapy Specialists (TexPTS) ... Gruene Road in Building 2. The clinic is the group’s second in New Braunfels ... opening the company’s second New Braunfels location brings things full circle for the group, ...
(Date:3/23/2017)... ... March 23, 2017 , ... Dilger-Maxwell ... of the Norwalk and Vermillion areas, celebrates the newest charity campaign in ... nonprofit, community-based substance abuse prevention and peer recovery support organization providing vital ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... HICKORY, N.C. , March 23, 2017  Transportation ... accolades as an end-to-end supply chain management firm with ... of Consumer Product Solutions Rick Zaffarano was ... Star of the Supply Chain by the only publication ... the global food supply chain. "Rick has ...
(Date:3/23/2017)... 2017 Summary ... pipeline guide Primary Hyperoxaluria - Pipeline Review, H1 ... (Genito Urinary System And Sex Hormones) pipeline landscape. ... by recurrent kidney and bladder stones. It results ... Symptoms include blood in the urine, pain when ...
(Date:3/23/2017)... 23, 2017 Research and Markets has announced ... report to their offering. ... The global oxygen therapy devices market to grow ... The report, Global Oxygen Therapy Devices Market 2017-2021, has been ... experts. The report covers the market landscape and its growth prospects ...
Breaking Medicine Technology: