Navigation Links
Genetic factor holds key to blood vessel health
Date:11/19/2012

Researchers at Case Western Reserve University School of Medicine have identified a genetic factor that prevents blockages from forming in blood vessels, a discovery that could lead to new therapies for cardiovascular diseases.

The findings are described in the Nov. 19 issue of the Journal of Clinical Investigation.

Researchers led by Mukesh K. Jain, MD, FAHA, professor of medicine, Ellery Sedgwick Jr. Chair and director of Case Cardiovascular Research Institute at Case Western Reserve School of Medicine, found that a shortage of the genetic factor KLF4, which regulates endothelial cells lining the interior of blood vessels, makes the lining more prone to the buildup of harmful plaque and fat deposits. In addition they showed that the deficiency of KLF4 also made the blood vessel more susceptible to clot formation. The plaque buildup (called atherosclerosis) narrows vessels and provides the foundation for clot formation (called thrombosis) that leads to heart attack and stroke.

Conversely, sufficient levels of KLF4, protect the inner lining of blood vessels, from toxins and other harmful agents that trigger the buildup of plaque and clot formation.

"This research answers a fundamental question in blood vessel health, identifying KLF4 as a master regulator of the most cardinal functions of endothelial cells," says Jain, who is also chief research officer of Harrington Heart & Vascular Institute at University Hospitals Case Medical Center.

"The fact that the level of these genetic factors can be altered in human disease suggests that targeting them may be a viable therapeutic strategy," Jain says.

The researchers are now developing tools to identify small molecules that increase KLF4 levels. Long-term, the goal is to identify a new class of molecules to develop a drug that works with those already used to treat heart disease. Another possibility is to modify existing drugs that can boost KLFs levels.
'/>"/>

Contact: Jessica Studeny
jessica.studeny@case.edu
216-224-3997
Case Western Reserve University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. IntegraGen launches ARISk test, a genetic screening tool for autism in high-risk children
2. 2 genetic deletions in human genome linked to the development of aggressive prostate cancer
3. Head, Body Lice Are Genetically Very Similar
4. Certain Genetic Regions May Be Tied to Osteoporosis
5. Study of half siblings provides genetic clues to autism
6. Genetic variants, tobacco exposure and lung cancer risk
7. Research Gets Closer to Genetic Roots of Glaucoma
8. Moffitt researcher awarded GE grant to develop tool to detect breast cancer metastasis genetic risks
9. Genetically modified T cell therapy shown to be safe, lasting in decade-long study of HIV patients
10. Some women may be genetically predisposed to smoking-related hot flashes
11. Genetic abnormalities in benign or malignant tissues predict relapse of prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/7/2015)... (PRWEB) , ... July 07, 2015 , ... Healthpointe ... pain management team. Dr. Alupay, an anesthesiologist and pain management specialist, will be evaluating ... as well as neurological conditions. , After receiving his Bachelor of Science in Biology ...
(Date:7/7/2015)... (PRWEB) , ... July 07, 2015 , ... ... heart of Downtown Detroit was the site of the National Baptist Convention 110th ... Initiative. Focusing on encouraging and promoting the collaboration of churches and their congregations, ...
(Date:7/7/2015)... ... July 07, 2015 , ... With a new community ... up with Soldiers’ Angels and announced a new charity campaign to raise funds in ... mission of Soldiers’ Angels, which was created especially to care for the special needs ...
(Date:7/7/2015)... ... July 07, 2015 , ... America is blessed with people ... Nominate A Hero program offers a special way to say “thanks.” Give them ... a $250 gift card and their place on the “Wall of Heroes.” , ...
(Date:7/7/2015)... ... July 07, 2015 , ... ... have jointly announced a partnership focused on providing knowledge organizing and differential diagnostic ... study will be conducted with NIWH trained patient health educators, utilizing the Knowledge ...
Breaking Medicine News(10 mins):Health News:Dr. Pedro S. Alupay, M.D., Now Providing Pain Management Services at Healthpointe in Irwindale 2Health News:Dr. Pedro S. Alupay, M.D., Now Providing Pain Management Services at Healthpointe in Irwindale 3Health News:A Forever Recovery CEO Per Wickstrom Speaks to Audience at National Baptist Convention's 11th Annual Health Fair 2Health News:A Forever Recovery CEO Per Wickstrom Speaks to Audience at National Baptist Convention's 11th Annual Health Fair 3Health News:Clear Insurance Group and Nonprofit Soldiers’ Angels Initiate New Charity Campaign in San Antonio, TX to Provide Aid and Comfort for Veterans 2Health News:Clear Insurance Group and Nonprofit Soldiers’ Angels Initiate New Charity Campaign in San Antonio, TX to Provide Aid and Comfort for Veterans 3Health News:California Casualty Wants to Know: "Who Is Your Hero?" 2Health News:Isabel Healthcare and the National Institute of Whole Health Announce Partnership for a Pilot Study Using the Isabel Diagnostic Support Tool and Knowledge Organizer 2Health News:Isabel Healthcare and the National Institute of Whole Health Announce Partnership for a Pilot Study Using the Isabel Diagnostic Support Tool and Knowledge Organizer 3
... to IAC for Electronic ClaimsJACKSONVILLE, Fla., April 27 ... network, today announced that Insurers Administrative Corporation (IAC) ... HIPAA compliant electronic claims. As an Availity client, ... the Availity(R) Health Information Network free of charge.(Logo: ...
... officials checking persons entering U.S. for signs of sickness , , ... Monday that the threat posed by the swine flu outbreak ... alarm," as the United States began monitoring its borders to ... , "The Department of Health and Human Services has declared ...
... 27 Orchid Cellmark Inc. (Nasdaq: ORCH ), ... release its first quarter 2009 financial results on Thursday, May ... a conference call and webcast to discuss the results at ... discuss financial results for the 2009 first quarter as well ...
... free lecture notes and course notes, has been launched. The ... course materials on the internet. It includes thousands of courses ... registered users to post open courseware that they created or ... , ...
... Community Health ResourcesBRIDGEWATER, N.J., April 27 Sanofi-aventis ... Partnership (CHP), It,s In Our Hands , ... Health (NMQF) Disparities Leadership Summit in Washington, DC. ... that aims to decrease health disparities among minority ...
... ,s Free Event Is One Of Nation,s ... hospital systems -- Cleveland Clinic, University Hospitals and MetroHealth ... nation,s largest free medical clinics May 2-3 at the ... by Remote Area Medical (RAM) Ohio, will bring together ...
Cached Medicine News:Health News:Insurers Administrative Corporation Joins the Availity Network 2Health News:Obama Says Swine Flu Outbreak No Cause for 'Alarm' 2Health News:Obama Says Swine Flu Outbreak No Cause for 'Alarm' 3Health News:Obama Says Swine Flu Outbreak No Cause for 'Alarm' 4Health News:Obama Says Swine Flu Outbreak No Cause for 'Alarm' 5Health News:Orchid Cellmark to Announce First Quarter 2009 Financial Results on May 7, 2009 2Health News:Orchid Cellmark to Announce First Quarter 2009 Financial Results on May 7, 2009 3Health News:ShareCourseware.org - Free Lecture Notes and Course Notes Sharing Site Launched 2Health News:ShareCourseware.org - Free Lecture Notes and Course Notes Sharing Site Launched 3Health News:ShareCourseware.org - Free Lecture Notes and Course Notes Sharing Site Launched 4Health News:ShareCourseware.org - Free Lecture Notes and Course Notes Sharing Site Launched 5Health News:Sanofi-aventis Affirms Its Commitment to Partnering with Local Communities to Improve Hispanic and African American Health 2Health News:Sanofi-aventis Affirms Its Commitment to Partnering with Local Communities to Improve Hispanic and African American Health 3Health News:Sanofi-aventis Affirms Its Commitment to Partnering with Local Communities to Improve Hispanic and African American Health 4
(Date:7/7/2015)... LEHIGH VALLEY, Pa. , July 7, 2015  Air ... efficiency of its medical oxygen supply systems—including high efficiency systems ... the 52 nd ASHE Annual Conference and Technical Exhibition ... ASHE attendees are invited to stop by ... help reduce their oxygen usage by as much as 30 ...
(Date:7/7/2015)... , June 30, 2015 ... of the "Outlook of Global Biologic Drug Discovery ... The global biologic drug discovery outsourcing market will likely ... 2020, and may reach $11.4 B by 2020. ... biologics (or biopharmaceuticals) have become a new but important ...
(Date:7/7/2015)... , July 7, 2015 Biobanks ... Helping Your Influence  ,Are you interested ... so, now gain technological and commercial predictions from 2015. ... explore trends in research and development, results, opportunities and ... visiongain shows you what,s possible for biobanking and ...
Breaking Medicine Technology:Air Products Highlights Reliability and Efficiency of Its Medical Oxygen Supply Systems at ASHE Conference and Exhibition 2Outlook of Global Biologic Drug Discovery Outsourcing Market to 2020 2Outlook of Global Biologic Drug Discovery Outsourcing Market to 2020 3Biobanking for Medicine: Technology, Industry and Market 2015-2025 2Biobanking for Medicine: Technology, Industry and Market 2015-2025 3Biobanking for Medicine: Technology, Industry and Market 2015-2025 4Biobanking for Medicine: Technology, Industry and Market 2015-2025 5Biobanking for Medicine: Technology, Industry and Market 2015-2025 6Biobanking for Medicine: Technology, Industry and Market 2015-2025 7Biobanking for Medicine: Technology, Industry and Market 2015-2025 8Biobanking for Medicine: Technology, Industry and Market 2015-2025 9Biobanking for Medicine: Technology, Industry and Market 2015-2025 10
... ergonomic chairs with concave seats and ... Select options like seats, backrests, armrests, ... chairs are recommended for the following ... static control, health care and office. ...
... Basic ergonomic chairs with concave seats ... • Select options like seats, backrests, ... BTC/1Q chairs are recommended for the ... room, static control, health care and ...
... Basic ergonomic chairs with concave ... support • Select options like seats, ... are recommended for the following environments: ... control, health care and office. • ...
... Basic ergonomic chairs with concave seats ... • Select options like seats, backrests, ... BTT/1P chairs are recommended for the ... room, static control, health care and ...
Medicine Products: