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Genetic evidence points to potential therapeutic bypass for autoimmune process
Date:3/2/2009

bation with a combination of immune system molecules cytokines (Transforming Growth Factor-beta and Interleukin-2) and specific ligands for activating the T cell receptor.

Besides the molecular requirements for Treg development, the study also provides new insight into the way pathogens, in this case mouse CMV, hijack the host immune system by deliberately inducing Treg cells. This reduces protective anti-viral T cell responses, increasing the survival and replication of viral pathogens in infected individuals.


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Contact: Nick Miller
nicholas.miller@cchmc.org
513-803-6035
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

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