Navigation Links
Genetic evidence points to potential therapeutic bypass for autoimmune process
Date:3/2/2009

cause it shows the flexibility of the immune system to regulate T cell responses. If we understand the molecular requirements of these pathways we can potentially use these as targets for therapeutic intervention which is the eventual goal."

This may include repressing immune response in autoimmune disease by increasing Treg development, or doing the opposite in chronic infectious diseases by inhibiting Treg development and promoting activation of T cells, said Dr. Hoebe, who started this study with the first author, Michael J. Barnes, a graduate student at The Scripps Research Institute in La Jolla, Calif. The department of Genetics and Immunology at Scripps was the key collaborator on the study.

Dr. Hoebe's lab uses a unique experimental approach, where they randomly introduce genetic mutations in mice that reflect genetic changes in humans. This is done to discover essential genes required for a normal immune system, in this case that of Treg development. With this approach, the researchers identified a mouse that almost completely lacked Treg cells. The researchers determined the cause of this Treg deficiency to be caused by a specific point mutation in the Carma1 gene, which they named the king mutation.

The researchers took the Carma1-deficient mice and infected them with a mouse variant of human cytomegalovirus which is related to herpes and chickenpox viruses and can remain dormant or cause serious illness in people with compromised immune systems. Although the mice lacked thymus-derived Treg cells, they still had small pools of peripheral Treg cells that greatly expanded after the animals were infected with the virus.

To further investigate the requirements for Treg development in these mice, the researchers were able to induce Treg cells in external laboratory cell cultures from Carma1-deficient, peripheral T lymphocyte white blood cells. They determined these cells could still be transformed into Treg cells by incu
'/>"/>

Contact: Nick Miller
nicholas.miller@cchmc.org
513-803-6035
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Interleukin Genetics Announces Conference Call to Discuss Fourth Quarter 2008 Results
2. Cascade of Studies, New Clinical Tests Build the Case for Genetic Testing in Pharmacy Care Says Medco Expert
3. Big-hearted fish reveals genetics of cardiovascular condition
4. Six Questions Consumers Should Ask About Genetic Tests
5. Proteasome inhibition affects epigenetic mechanisms
6. Knowledge of genetics improves uncertain medication
7. Genetic Mutations Linked to Deadly Brain Cancer
8. Genetics May Help Fine-Tune Warfarin Dosage
9. Exploring Genetic Link Between Migraines, Cardiovascular Trouble
10. Researchers identify novel genetic markers linked to increased risk of heart attack
11. Genetic Code of Common Cold Cracked
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/20/2014)... The Arizona Advanced Manufacturing ... National Manufacturing Day by opening its doors to the ... additive manufacturing labs will be offered between 10 a.m. ... Southern and Dobson campus (1833 W. Southern Ave, Mesa, ... , The AzAMI at MCC was established in the ...
(Date:9/20/2014)... “Motherhood is a wonderful gift and a huge responsibility,” ... article , “We know that you want to care for ... want to do as well.” , The article explains to ... their Family Physicians who practice obstetrics while pregnant, during delivery, ... To learn more about Community Health Center of Snohomish County ...
(Date:9/20/2014)... (PRWEB) September 20, 2014 The children ... the balanced and active play they need. An empty ... Center - Lakeview Campus was transformed into a kid-designed ... of 150+ volunteers from Branches (@BranchesFL), ESPN (@TeamESPN), Disney ... , KaBOOM! believes a playground is more than a ...
(Date:9/19/2014)... York, NY (PRWEB) September 20, 2014 ... moderate revenue growth for the Vision Insurance industry ... pace, to the detriment of industry margins. From ... noticeably increase. Industry operators provide coverage for routine ... discounted pricing for eyeglasses, contact lens and refractive ...
(Date:9/19/2014)... 19, 2014 Are you tired of ... problems with seasonal allergies or sinus congestion? Fortunately, an ... alternative. , She conceived of Nose Pal to ... runny nose in public. Since it prevents nasal drip ... sanitary conditions, particularly when cooking or working closely with ...
Breaking Medicine News(10 mins):Health News:National Manufacturing Day Open House at Mesa Community College Oct. 3 2Health News:Newest Article from Community Health Center of Snohomish County Highlights The Importance of Proper Health Care for Expectant Mothers 2Health News:Volunteers Improve Miami Kids’ Lives and Futures with Play 2Health News:Volunteers Improve Miami Kids’ Lives and Futures with Play 3Health News:Volunteers Improve Miami Kids’ Lives and Futures with Play 4Health News:Vision Insurance in the US Industry Market Research Report from IBISWorld Has Been Updated 2Health News:Vision Insurance in the US Industry Market Research Report from IBISWorld Has Been Updated 3Health News:Vision Insurance in the US Industry Market Research Report from IBISWorld Has Been Updated 4Health News:Nasal Drip Eliminator Invented by InventHelp Client (LCC-218) 2
... with Autism is the focus of the research of one ... Economic and Social Research Council (ESRC) and the Young Foundation. ... the causes of autism rather than understanding it as a ... over a period of three years Dr Elizabeth Pellicano, from ...
... Lady Laura Bush,today saluted the U.S. Department of ... Prevention Initiative, announced today at,the National Prevention Summit, ... weight for children., Mrs. Bush delivered the ... event that highlights new approaches to prevention,and health ...
... Ventas, Inc. (NYSE:,VTR) ("Ventas" or the "Company") said ... dividend of $0.475 per share, payable in cash,on December ... 2007. The,dividend is the fourth quarterly installment of the ... quarterly installment of the Company,s 2007 annual dividend,will be ...
... bizarre behaviors and sudden deaths , , TUESDAY, Nov. ... Drug Administration advisory panel recommended Tuesday that the prescription ... label to reflect reports of bizarre behaviors and deaths ... a 9-5 vote, said that drug maker Roche Holding ...
... SAN DIEGO, Nov. 27 Gen-Probe Incorporated,(Nasdaq: GPRO ... the NASDAQ,20th Investor Program in London on Thursday, December ... a.m. Eastern Time). The,presentation is scheduled to be webcast ... investor information section of Gen-Probe,s website at, http://www.gen-probe.com . ...
... Address Growing Healthcare Trends and the Tools Health Plans ... ... Portico Systems, the leader in,Provider Network Management solutions, will host a ... practices for,provider network management. The complimentary series starts Tuesday,December 4th, showcasing ...
Cached Medicine News:Health News:Autism focus of prize winning research 2Health News:HHS Launches Childhood Overweight and Obesity Prevention Initiative 2Health News:HHS Launches Childhood Overweight and Obesity Prevention Initiative 3Health News:Ventas Declares Regular Quarterly Dividend of $0.475 Per Share 2Health News:Ventas Declares Regular Quarterly Dividend of $0.475 Per Share 3Health News:Ventas Declares Regular Quarterly Dividend of $0.475 Per Share 4Health News:FDA Panel Backs Stronger Warning for Tamiflu 2Health News:FDA Panel Backs Stronger Warning for Tamiflu 3Health News:Gen-Probe to Webcast Presentation at NASDAQ 20th Investor Program 2Health News:Portico Systems Offers Webinar Series to Share Provider Network Management Best Practices 2
(Date:9/19/2014)... -- Harwood Feffer LLP ( www.hfesq.com ) is investigating ... BioPharma, Inc. ("PDL" or the "Company") (Nasdaq: ... fiduciary duties to shareholders or violated the federal securities ... disclosed: "On September 11, 2014, [PDL] was orally notified ... LLP ("EY"), that it was resigning effective September 11, ...
(Date:9/19/2014)... /PRNewswire-iReach/ -- Market Research Report on Global ... a professional and in-depth market survey on ... report firstly reviews the basic information of ... manufacturing technology. The report then explores global ... listing their product specification, capacity, Production value, ...
(Date:9/19/2014)... CHICAGO, Ill. , Sept. 19, 2014  The ... ABBV ) declared a quarterly cash dividend of $0.42 ... payable Nov. 17, 2014 to stockholders of record at ... About AbbVie AbbVie is a global, research-based biopharmaceutical ... company,s mission is to use its expertise, dedicated people ...
Breaking Medicine Technology:Harwood Feffer LLP Announces Investigation of PDL BioPharma, Inc. 2Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 2Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 3Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 4Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 5
... of Orange Park is hosting a car wash to raise money ... AM at the Hooters of Orange Park located at 1740 Wells ... from the car wash will go toward the Kelly Jo Dowd ... the country is raising money through various charitable efforts in the ...
... Reinforce March of Dimes Message: Start Taking a Vitamin ... Women who take folic acid supplements for at ... their risk of having a premature baby by half, ... journal, PLOS Medicine.The study links pre-conceptional folate supplementation of ...
Cached Medicine Technology:Taking Folic Acid for a Year Before Pregnancy May Reduce Risk of Preterm Birth 2
30 Degree Angle Shaft with 1.0mm 90 Degree Angle Tip; in stainless steel....
0.5mm "K" hook. Rounded knurled handle; shaft angled 11mm from tip; overall length 120mm, in Titanium....
Lightly Curved-Blunt Tips Rounded Blades; 1mm Eye in Blades; 27mm from mid screw to tip. Matte finish; Stainless Steel, overall length 120mm...
... Catheter is indicated for balloon ... of a coronary artery or ... purpose of improving myocardial perfusion. ... also designed to provide distal ...
Medicine Products: