Navigation Links
Genetic disease treatments and pharmacogenetics: From scientific discovery to medical delivery
Date:11/14/2008

racts with the huntingtin protein, and altered function of PPARd contributes to HD neurodegeneration. If PPARd is involved in this neurological disease, then tractable therapies to boost PPARd would be immediately available, as two recent lines of investigation make PPARd an attractive therapeutic target: (1) highly selective and powerful pharmacological agonists for PPARd have been developed and are currently being studied in clinical trials in humans; and 2) PPARd mediates pro-survival signaling in response to retinoic acid, a compound that has been used for years to treat human patients with leukemia and brain tumors.

"My colleagues and I are very excited about the surprising results of our most recent research on Huntington's disease, since the findings could ultimately lead to the first potential treatment for this currently fatal disease," LaSpada said. "Furthermore, our findings suggest there are drugs that are already available and currently being used in human patients that could be possible new therapies for Huntington's disease."

Albert R. La Spada, M.D., Ph.D., FACMG, is Director of the Center for Neurogenetics and Neurotherapeutics and Associate Professor of Laboratory Medicine, Medicine (Medical Genetics), Pathology, and Neurology at the University of Washington, Seattle. La Spada's research efforts have uncovered a number of connections between pathways involved in transcription and neuron dysfunction. His current work focuses on investigating the molecular basis of neurodegenerative disease.

EIGHT-YEAR CLINICAL OUTCOMES OF ENZYME REPLACEMENT THERAPY IN 884 CHILDREN WITH TYPE I GAUCHER DISEASE

Gaucher disease is a rare genetic disorder that occurs when a person lacks an enzyme called glucocerebrosidase. The most common form of this disorder is type 1 Gaucher disease. Type 1 Gaucher disease can start at any age, but recently it has been shown that about half of all patients are diagnosed before 18 years of age
'/>"/>

Contact: Kristen Long
klong@ashg.org
240-281-2386
American Society of Human Genetics
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8

Related medicine news :

1. Research demonstrates differing genetic makeup of lung cancer in African-American patients
2. New technique to study the genetics of breast cancer
3. Genetic blueprint revealed for kidney design and formation
4. Know the Myths and Facts About Family Health History: American College of Medical Genetics
5. Impulse control area in brain affected in teens with genetic vulnerability for alcoholism
6. Interleukin Genetics Announces Conference Call and Webcast to Discuss Third Quarter 2008 Business Results
7. Researchers ID Genetic Markers for Esophageal Cancer
8. Genetic disorder sheds light on enzymes role in bone metabolism
9. Penn scientists map molecular regulation of fat-cell genetics
10. Tackling a hard-to-treat childhood cancer by targeting epigenetic changes
11. Tackling Hard-to-treat Childhood Cancer by Targeting Epigenetic Changes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... 22, 2015 Deer Path of Huntley ... Valentine’s Day Happy Hour from 3 p.m. to 4 p.m. on ... Parkway in Huntley, Illinois, serves adults with physical disabilities between the ... include Valentine's Day treats, games and sweetheart-themed karaoke. , For more ...
(Date:1/22/2015)... The City of West Hollywood hosted a news conference on Thursday, ... of the Supreme Court decision Roe v. Wade, which legalized abortion ... Roe vs. Wade decision and the fight to protect a women’s ... of West Hollywood Councilmember Abbe Land. “We need to continue to ...
(Date:1/22/2015)... VogueQueen is a seasoned and trusted leader who ... are thrilled to have it lead the wedding dress industry ... of prom dresses for the global market. , “The CEO ... and he focuses on continuing the goal of operational excellence ...
(Date:1/22/2015)... January 23, 2015 AngelWeddingDress, the premier ... 2015 maternity wedding dresses. View website of ... looking for maternity wedding dresses online for a bridal ... with high quality for them. Its maternity wedding dresses ...
(Date:1/22/2015)... New York (PRWEB) January 22, 2015 ... after Fresenius Medical Care recalled its GranuFlo and NaturaLyte ... multidistrict litigation underway in U.S. District Court, District of ... dated January 20th, the Court has remanded a case ...
Breaking Medicine News(10 mins):Health News:Deer Path of Huntley Affordable Assisted Living to Host Valentine's Day Happy Hour 2Health News:VogueQueen Unveils New Designs of Prom Dresses for 2015 2Health News:AngelWeddingDress Has Recently Released Its Collection Of 2015 Maternity Wedding Dresses 2Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 2Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 3Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 4
... Board (PTCB) - the pioneer in the certification of pharmacy technicians ... will be available in continuous testing format at Pearson Professional Centers ... official pass or fail result at the test center after the ... ...
... match needs, culture of staff , , TUESDAY, Jan. 27 (HealthDay ... its rate of patient deaths and complications, a new study ... the researchers report. , Although there are many kinks to ... the National Center for Policy Analysis in Dallas, "I assume ...
... Planning Grant to Partners in Care Foundation will identify ... Jan. 27 The SCAN Foundation today announced it ... Fernando Valley based Partners in Care Foundation (Partners) with ... services for seniors and caregivers in the Santa Clarita ...
... Taking Control of Your Diabetes (TCOYD) conference and health ... Augusta Marriott Hotel, bringing national and local medical experts ... diabetes, those at risk for diabetes, and their loved ... programs.Leading specialist will discuss practical advice and developments in ...
... Nev., Jan. 27 MedCom USA, Inc. (OTC Bulletin ... and financial transaction solutions for the healthcare industry, which ... LLC and Absolute Medical Software Systems, a leading provider ... solutions for the healthcare and dental industry is pleased ...
... Tenn., Jan. 27 MAXIMUS MULTIMEDIA INTERNATIONAL ... provided a glimpse of what is in store for ... 2009 when its flagship pilot program hit the stage ... http://www.newscom.com/cgi-bin/prnh/20090127/CL62645 )The new program, Maximus Overdrive, is ...
Cached Medicine News:Health News:Pharmacy Technician Certification Board (PTCB) Unveils New Testing Features for 2009: PTCB Exam to be Offered Daily; Test Results Given to Candidates Immediately in 2009 2Health News:Pharmacy Technician Certification Board (PTCB) Unveils New Testing Features for 2009: PTCB Exam to be Offered Daily; Test Results Given to Candidates Immediately in 2009 3Health News:'Wired' Hospitals Post Lower Death, Complication Rates 2Health News:'Wired' Hospitals Post Lower Death, Complication Rates 3Health News:The SCAN Foundation Funds New Program for Santa Clarita and South Los Angeles Seniors and Those Who Care for Them 2Health News:The SCAN Foundation Funds New Program for Santa Clarita and South Los Angeles Seniors and Those Who Care for Them 3Health News:Taking Control of Your Diabetes Conference Heads to Augusta to Bring Answers, Advocacy and Hope - February 28, 2009 2Health News:MedCom USA, Inc. Announces Appointment of One New Board Member and Removal of Two Existing Board Members 2Health News:MedCom USA, Inc. Announces Appointment of One New Board Member and Removal of Two Existing Board Members 3Health News:Maximus Rocks the Doors off Rocketown at Cancer Benefit Concert Featuring the Pink Spiders, The Running and SupreX 2Health News:Maximus Rocks the Doors off Rocketown at Cancer Benefit Concert Featuring the Pink Spiders, The Running and SupreX 3
(Date:1/23/2015)... 23, 2015 Tianyin Pharmaceutical Inc. (NYSE Amex: ... the development and sale of patented biopharmaceutical medicine, modernized ... ingredients (API) today announced the business and development progress ... 1. Following the September 2014 JCM application (No. ...
(Date:1/22/2015)... 2015  ResMed Inc. (NYSE: RMD ) today announced ... the quarter was $423.0 million, a 10 percent increase compared ... increase on a constant currency basis). Net income was $91.2 ... ended December 31, 2013. Diluted earnings per share for the ...
(Date:1/22/2015)...  Profil Institute for Clinical Research, Inc., a clinical research ... a new textbook,  Translational Research Methods for Diabetes, Obesity ... global scientific publisher. The textbook is the ... in early phase clinical studies of new drugs for ...
Breaking Medicine Technology:TPI's JCM Updates on Import Registration for International Clients 2TPI's JCM Updates on Import Registration for International Clients 3TPI's JCM Updates on Import Registration for International Clients 4ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 2ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 3ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 4ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 5ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 6ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 7ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 8ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 9ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 10ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 11New Textbook "Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development" Provides Critical Review Of Current And Emerging Clinical Investigation Methods 2New Textbook "Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development" Provides Critical Review Of Current And Emerging Clinical Investigation Methods 3
... 2012  OnSiteRx®, Inc. ( http://www.onsiterx.com ), parent organization for ... Network, announces today that they have successfully implemented the ... long-term care facility in the state of Arizona. ... patient safety and lower medication cost," states Dr. Reef ...
... (OTC Link Platform: BNVI.PK) a pharmaceutical company focused on ... for women,s health and cancer, announced today that it ... 2012 at 1:30 PM PST to discuss its 2011 ... (Logo:  http://photos.prnewswire.com/prnh/20111110/SF04662LOGO ) ...
Cached Medicine Technology:OnSiteRx® Launches First for Arizona: Automated Drug Dispensing in Nursing Home 2
Medtronic Ophthalmics offers a comprehensive selection of corneal trephine,blades and handles. Handcrafted, sharp, uniform blade edges promote a,symetrical and vertical cut of all corneal layers....
Each handle is designed to fit a specific trephine size....
Medtronic Ophthalmics offers a comprehensive selection of corneal trephine,blades and handles. Handcrafted, sharp, uniform blade edges promote a,symetrical and vertical cut of all corneal layers....
Each handle is designed to fit a specific trephine size....
Medicine Products: