Navigation Links
Genetic disease treatments and pharmacogenetics: From scientific discovery to medical delivery
Date:11/14/2008

a successful enzyme replacement therapy for children with Type I Gaucher Disease, and new research findings that offer important new clues that will facilitate more precise and compartment-specific cancer treatment options.

Brief summaries of the major research findings reported in these four abstracts are included below:

GENOME-WIDE ASSOCIATION SCAN FOR GENETIC DETERMINANTS OF WARFARIN DOSE

A growing number of geneticists are using genome-wide association studies (GWAS) to systematically search for and identify single nucleotide polymorphisms (SNPs), which are single base changes in the human DNA sequence that can cause differences in genetic characteristics. GWAS may also detect genes that are associated with a particular health condition, or with variation in patient response to prescribed drugs.

In this session, Ralph E. McGinnis, Ph.D., a Statistical Geneticist at the Wellcome Trust Sanger Institute (Cambridge, UK), will discuss the results of new research that that he and his colleagues have recently completed which extends this genome-wide association scan (GWAS) method to investigate the genetic aspects of drug response (pharmacogenetics) related to predicting appropriate warfarin dose.

Warfarin is the most widely prescribed drug used to reduce blood clotting in order to protect high-risk patients from experiencing a stroke, deep vein thrombosis, pulmonary embolism, heart attack, or other serious coronary malfunction. However, a combination of genetic and non-genetic factors can cause patients to exhibit 10- to 20-fold variation in the required dose (RD) of warfarin needed to achieve an adequate level of blood thinning, which means that initial prescribed doses may be too low (risking blood clots and/or failure to protect the patient from developing life-threatening health conditions, such as stroke or heart attack) or too high (risking over-anticoagulation and severe bleeding). Therefore, associated SNPs
'/>"/>

Contact: Kristen Long
klong@ashg.org
240-281-2386
American Society of Human Genetics
Source:Eurekalert

0

GOOD

Page: 1 2 3 4 5 6 7 8

Related medicine news :

1. Research demonstrates differing genetic makeup of lung cancer in African-American patients
2. New technique to study the genetics of breast cancer
3. Genetic blueprint revealed for kidney design and formation
4. Know the Myths and Facts About Family Health History: American College of Medical Genetics
5. Impulse control area in brain affected in teens with genetic vulnerability for alcoholism
6. Interleukin Genetics Announces Conference Call and Webcast to Discuss Third Quarter 2008 Business Results
7. Researchers ID Genetic Markers for Esophageal Cancer
8. Genetic disorder sheds light on enzymes role in bone metabolism
9. Penn scientists map molecular regulation of fat-cell genetics
10. Tackling a hard-to-treat childhood cancer by targeting epigenetic changes
11. Tackling Hard-to-treat Childhood Cancer by Targeting Epigenetic Changes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2013)... GA (PRWEB) May 21, 2013 Patients of ... Care who have lost teeth due to gum disease and ... surgery for gum disease treatment with laser gum surgery. ... which have the highest success rate out of all tooth ... (LANAP) is a relatively new procedure cleared by the Food ...
(Date:5/21/2013)... (PRWEB) May 21, 2013 ContinuCare Home ... Texas Department of Aging and Disability Services. After completing ... employee interviews, ContinuCare Home Health was found to ... review is part of the Department of Aging and ... aging and disability services, supports and opportunities that ...
(Date:5/21/2013)... results from SOURCE XT one of the largest, ... reported today at EuroPCR 2013 show good clinical outcomes ... success for all access approaches, valve sizes and delivery ... 2688 consecutively enrolled patients (mean age 81.5 years) undergoing ... centres in 17 countries between July 2010 and October ...
(Date:5/21/2013)... (PRWEB) May 21, 2013 The ... on cable networks and cable channels across the country, ... on its YouTube channel. The producers of the series ... in the shipping industry, the manufacturing industry, health-related companies, ... medical facilities and medical practitioners in all parts of ...
(Date:5/21/2013)... (PRWEB) May 21, 2013 Modern ... the help of Texas Counseling’s Sexuality and Relationship ... and the development of healthier habits for their ... available for both couples and individuals at Texas ... their relationships and learn skills to develop long ...
Breaking Medicine News(10 mins):Health News:Shenk Dental Care Stimulates Bone Growth for Gum Disease Patients Seeking Dental Implants with Laser Gum Surgery in Atlanta, GA 2Health News:ContinuCare Home Health, Inc. Receives Perfect Report from the Texas Department of Aging and Disability Services 2Health News:In View hosted by Larry King Announces New Videos on its YouTube Channel 2Health News:Workshops Offered To Identify Underlying Challenges That Put Strain On Relationships 2
... recently approved of a new prescription treatment for gingivitis, ... Gingivitis is an inflammation of the gums haracterized as ... plaque-forming bacteria that live in the mouth and on ... substances released by the bacteria cause the gum inflammation. ...
... may be equivalent to losing 4 kilos of load in ... ,Researchers from the Wake Forest University had conducted a ... on the osteoarthritis of the knee and had reported that ... in obese elderly patients can reduce the load on the ...
... the guidelines for feeding children are for those who are ... 2 yrs. Hence Parents have often wondered what’s best to ... 24 months. , ,The Agricultural Research Service scientists ... the Baylor College of Medicine in Houston, Texas, along with ...
... points out to the fact that uncomplicated twin pregnancies ... thought before. ,Researchers of Imperial College London report ... risk from intrauterine deaths. In monochorionic diamniotic twin pregnancy, ... different amniotic sacs and often are the most common ...
... to a study published in Archives of Internal Medicine ... treated. The retrospective cohort study was conducted to determine ... chemotherapy for breast cancer. Adjuvant chemotherapy is given to ... the primary tumor. This improves the overall survival in ...
... first time an interesting report looks at the relationship between ... to appear in the August 1, 2005 issue of CANCER. ... for causing up to 11 percent of all cancer-related deaths ... is dependent on the stage of disease at the time ...
Cached Medicine News:Health News:Obese women with breast cancer may be under treated., 2Health News:Race an important links to the risk of advanced colorectal cancer 2
(Date:5/21/2013)... N.J. , May 21, 2013  Armada ... launch of the new Armada corporate website ( ... clearly communicate Armada,s unique and first-to-market services and ... company focused on the specialty pharmacy industry. ... expansion of the Armada business model in delivering ...
(Date:5/21/2013)... Hurel Corporation ("Hurel"), a world-leading provider of ... today announced the appointment of James S. ... of Directors. Dr. MacDonald is the former Executive Vice ... ("SPRI"), which was the pharmaceutical development arm of Schering ... in 2009. Over a career that has ...
(Date:5/21/2013)... Pa. , May 21, 2013  Lehigh Valley ... TRU-D SmartUVC TM devices, adding to its existing ... seven devices taking up residence within the network, LVHN ... the U.S. to proactively combat superbugs and provide the ... for Total Room Ultraviolet Disinfector, TRU-D – the signature ...
Breaking Medicine Technology:Armada Announces New Corporate Website to Showcase Expanded Services to Specialty Pharmacy Marketplace 2Hurel Corporation Appoints Leading Pharmaceutical Executive and Toxicologist Dr. James S. MacDonald to Board of Directors 2Lehigh Valley Expands Fleet of Superbug-Slaying Robots 2Lehigh Valley Expands Fleet of Superbug-Slaying Robots 3
... - CytoGenix, Inc. (CYGX.OB),announced today that Dr. Yin ... preclinical animal data for DNA vaccines made,using the ... conference to be held in Malaga, Spain between ... have successfully conducted tests of,synDNA(TM) based vaccines in ...
... WIRE)--May 23, 2007 -,ProtoKinetix Inc. (OTCBB:PKTX) has just ... Inc. at the University of Finland.,These outstanding results ... demonstrate the vital importance of this,molecule in the ... series of tests using AAGP(TM) on human embryonic ...
Cached Medicine Technology:CytoGenix to Present at 2007 International DNA Vaccines Conference,in Spain 2ProtoKinetix's AAGP Dramatically Increases Recovery Rate of,Cryopreserved Stem Cells 2
The SleepStyle 600 series with ThermoSmart delivers humidification with anti-rainout benefits. ThermoSmart technology offers a heated breathing tube that allows the constant delivery of optimal level...
... offers a display, ramp capabilities ... also has features that make ... session meter records the number ... than four hours - giving ...
... CPAP System is the smallest and lightest ... the market. It is designed to help ... while complying with therapy. The GoodKnight 420S ... date/time usage data. It also detects persistent ...
Micro-hematocrit tubes available in multiple sizes and additives for a wide range of capillary blood collection....
Medicine Products: