Navigation Links
Genetic differences may cause higher rates of prostate cancer in African-American men
Date:9/20/2011

WASHINGTON, D.C. Genetic differences in prostate cells seem to be a root cause of the prostate cancer disparities between African-American men and white men, according to findings presented at the Fourth AACR Conference on The Science of Cancer Health Disparities, held here Sept. 18-21, 2011.

Prostate cancer is the second most common cancer among U.S. men, with occurrences and mortality rates higher in African-American men compared to white men.

"There are a lot of socioeconomic and environmental factors that create differences in levels of prostate cancer in these two groups," said Bi-Dar Wang, Ph.D., assistant research professor of pharmacology and physiology at the George Washington University. "We've found that genetic elements play a role in these disparities as well."

Wang and colleagues analyzed normal and cancerous prostate tissue samples from African-American and white men who underwent prostate biopsies. They looked at two key genetic pieces: messenger RNA (mRNA), which carry codes from DNA that is then used to make proteins; and microRNA, shorter RNA strands that regulate that process by binding to mRNA and interrupt the gene expression or protein translation.

The results showed enough differences between African-American and white men to determine that each race has "population specific" mRNA and microRNA.

Specifically, they found nearly 400 mRNAs were differentially expressed between the cancerous prostate tissues of African-American and white men. These differences are crucial because mRNA and microRNA affect the biological pathways by which prostate cancer tumor formation is either promoted or stopped, according to Wang.

Wang believes these results are important because instead of focusing on socioeconomic and environmental factors, the researchers focused on biological differences, which could lead to more specialized treatment options in the future.

"It is still too early to conclude any novel treatment strategy based on our results. However, the genomic analyses of prostate cancers have revealed that differential mRNA and microRNA expression and the associated gene network rewriting may be critical in prostate cancer health disparities," said Wang. "These findings will advance our knowledge on the molecular mechanisms underlying prostate cancer disparities and may help with the development of novel strategies for prostate cancer detection and personalized treatment for African-American men."


'/>"/>

Contact: Jeremy Moore
Jeremy.Moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Related medicine news :

1. Genetic factors behind high blood pressure
2. Genetics may explain why calcium increases risk for prostate cancer
3. Genetics may predict why calcium increases risk for prostate cancer
4. Genetics, lifestyle provide clues to racial differences in head and neck cancer
5. Six new genetic variants linked to type 2 diabetes discovered in South Asians
6. Breakthrough in genetics of fibroids
7. Yale researchers use genetic code to engineer a living protein
8. Mayo Clinic wins grant to gauge genetic risk of heart attacks, adverse drug reactions
9. Honing in on the Genetics of MS
10. Stomach Cancer Tumors Have Genetic Differences: Researchers
11. Research discovers genetic link to Barretts esophagus, esophageal cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... , ... March 28, 2017 , ... Usually, the impending ... daily wardrobe. However, for those self-conscious about a double chin, this means more anxiety ... ideal solution. , “For most people, a double chin is undesirable,” Dr. Goldman ...
(Date:3/28/2017)... ... March 28, 2017 , ... Award-winning medical ... begin serving as new board chair for Orange County health care system CalOptima ... remainder of soon-to-be former chair Mark Refowitz’s term, which runs through June 30 ...
(Date:3/28/2017)... ... March 28, 2017 , ... With less than 10,000 dermatologists in ... quality care can be limited while the desire to conquer breakouts and eliminate skincare ... care for every customer online, today released its inaugural survey on the State of ...
(Date:3/28/2017)... (PRWEB) , ... March 28, 2017 , ... The Executives, ... to raise money to for the Toys for Tots Literacy Campaign at their Semi-Annual ... in excess of $70 billion, the U.S. ranks at number 14 internationally in literacy. ...
(Date:3/28/2017)... CA (PRWEB) , ... March 28, 2017 , ... ... which will be offered by the American Association of Integrative Medicine and available ... for healthcare providers at the AutismOne 2017 Conference in Colorado Springs. , Ed ...
Breaking Medicine News(10 mins):
(Date:3/27/2017)... LONDON , March 27, 2017 ... require to better understand Bayer and its partnering interests and ... since 2010 report provides an in-depth insight into the partnering ... On demand company reports are prepared upon purchase ... and company data. The report will be delivered ...
(Date:3/27/2017)... , March 27, 2017  Cryoport, Inc. (NASDAQ: ... it intends to offer shares of common stock in ... statement on file with the Securities and Exchange Commission ... other conditions, and there can be no assurance as ... or as to the actual size or terms of ...
(Date:3/27/2017)...  A new survey from the American ... Bidding Program (CBP) significantly reduced beneficiary choice and access ... choice forces beneficiaries to switch to unfamiliar or unsuitable ... AADE,s survey is the latest in a ... out the inherent problems with the CBP. Last year, ...
Breaking Medicine Technology: