Navigation Links
Genetic data shows that skin cancer risk includes more than UV exposure
Date:12/4/2012

BETHESDA, MD DECEMBER 4, 2012 -- It's common knowledge that excessive UV exposure from sunlight raises your chances for skin cancer, but predicting whether someone will actually develop skin cancer remains difficult. In a new research report, scientists from the University of Alabama at Birmingham (UAB) and the University of WisconsinMadison show that the risk for skin cancer involves numerous genetic factors including family history, ethnicity, and genetic variations specific to each individual. Using these factors, the researchers developed a more precise model for assessing risk, which is published in the December 2012 issue of the journal Genetics.

"We hope this study will ultimately contribute toward a better understanding of the genetics of complex traits and diseases," said Ana Ins Vzquez, PhD, lead author of the study from UAB's Department of Biostatistics. "Such an understanding is essential for the development of methods that can be used for early and improved prediction of genetic predisposition to diseases."

To make this discovery, the scientists used phenotypic and genetic information from more than 5,000 familial participants in the Framingham Heart Study to develop various models for assessing skin cancer risk. The researchers' most basic risk evaluation model included standard risk factors such as sex. Additional predictive models were developed by adding information on family history, ethnicity, and data from 41,000 genetic markers across the human genome. The predictive power of each model was evaluated, with the best prediction accuracy obtained from models that include all predictive risk factors -- those standard risk factors plus family history, ethnicity and genetic markers.

"Although there is no doubt that sun exposure increases your risk for skin cancer," said Mark Johnston, Editor-in-Chief of the journal Genetics, "it isn't clear how much of a risk it poses to each individual. This new model for assessing risk should prove useful to health care providers and public health officials, who play a crucial role in educating people about preventing skin cancer."


'/>"/>

Contact: Phyllis Edelman
pedelman@genetics-gsa.org
301-634-7302
Genetics Society of America
Source:Eurekalert

Related medicine news :

1. Genetics Society of Americas Genetics journal highlights for December 2012
2. McKinney Orthodontics Educates on New Evidence that Crooked Teeth are Genetic
3. Genetic factor holds key to blood vessel health
4. A new factor of genetic susceptibility to Alzheimers disease
5. Optogenetics illuminates pathways of motivation through brain, Stanford study shows
6. Genetics point to serious pregnancy complication
7. Worlds largest respiratory genetics study launches on World COPD Day
8. Genetic link between pancreatitis and alcohol consumption, says Pitt team
9. Wake Forest Baptist research goes global with genetic center in India
10. Molecular Genetics & Genomic Medicine: New open access journal launched by Wiley
11. New light on the genetic basis of inflammatory diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... Orleans, LA (PRWEB) , ... October 12, 2017 , ... ... centers in the U.S., announced today its plans to open a flagship location in ... will occupy the former Rooms To Go store next to Office Depot in the ...
(Date:10/12/2017)... , ... October 12, 2017 , ... IsoComforter, Inc. ( ... announced today the introduction of an innovative new design of the shoulder pad. ... you get maximum comfort while controlling your pain while using cold therapy. By utilizing ...
(Date:10/12/2017)... ... ... Asante, a nationally recognized health system in southern Oregon, ... health joint venture through an agreement, effective October 1, 2017, to create AccentCare ... company with Asante, delivering clinically integrated care, for the past eight years. This ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... Mohebi Hair Restoration, has recently contributed a medical article to the newly revamped ... cosmetictown.com. Dr. Mohebi’s article spotlights the hair transplant procedure known as Follicular ...
(Date:10/12/2017)... ... October 12, 2017 , ... Leading pediatric oncology experts at Children’s ... the 49th Congress of the International Society of Paediatric Oncology (SIOP) Oct. ... Center for Cancer and Blood Disorders at Children’s National, and Stephen P. Hunger, ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... 2017  Commended for their devotion to personalized service, SMP ... number one in the South Florida Business Journal,s 50 Fastest-Growing ... yearly list, the national specialty pharmacy has found its niche.  ... will soon be honored by SFBJ as the 2017 Power ... Set to receive his award in October, Bardisa said of ...
(Date:9/22/2017)... 2017  As the latest Obamacare repeal effort moves ... (R-LA) and Lindsey Graham (R-SC) medical ... device industry is in an odd place.  The industry ... excise tax on medical device sales passed along with ... patients, increased visits and hospital customers with the funding ...
(Date:9/18/2017)... 2017 EpiVax, Inc. ("EpiVax") a ... immune engineering, today announced a new NIH-funded ... ... and presents a challenge for traditional flu ... be effective. Using state-of-the-art bioinformatics and molecular modeling methods, ...
Breaking Medicine Technology: