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Genetic blueprint revealed for kidney design and formation
Date:11/10/2008

ioinformatics) then let the researchers see how different sets of genes cooperate through circuits or pathways, some already defined and others defined in this study for the first time. The genes cooperate by signaling each other, telling cells when to grow, when to make tubes, when to turn on pumps or perform other critical functions, said Bruce Aronow, Ph.D., study co-author and scientific director of the Center for Computational Medicine at Cincinnati Children's. The study also makes new headway into identifying different transcription factors "boss" genes that regulate the activity of other genes and the target genes they may activate or repress.

Given that about one in every 500 births results in a kidney development abnormality, this provides insight into genetic programs that are critical to deciding how kidney stem cells form structures in the adult kidney. The researchers identified genes that regulate DNA transcription, establish functioning developmental processes, and are involved in pattern specification, cell differentiation and organ compartment shaping.


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Contact: Nick Miller
nicholas.miller@cchmc.org
513-803-6035
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

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