Navigation Links
Genetic blueprint revealed for kidney design and formation
Date:11/10/2008

CINCINNATI Researchers have generated the first comprehensive genetic blueprint of a forming mammalian organ, shedding light on the genetic and molecular dynamics of kidney development.

Part of an international consortium sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), a research team led by Cincinnati Children's Hospital Medical Center reports the creation of a detailed genome-based atlas for understanding healthy and abnormal kidney development and disease. Published in the Nov. 11 Developmental Cell and featured on the journal's cover, the research provides a molecular genetic map detailing "gene expression analysis of all the major elements of kidney formation," according to the investigators.

The study, involving embryonic mice, shows how the entire genome is regulated to produce thousands of specific genes that are mixed and re-mixed to form genetic teams. The teams work together to direct formation of 15 embryonic compartments in the developing kidney from the earliest phases when stem cells are told how to differentiate into specific kidney cells to the development of nephrons, the kidney's primary functioning unit.

"This study establishes a baseline for what changing gene expression looks like in a normal developing kidney in a very global way," said Steven Potter, Ph.D., a researcher in the division of Developmental Biology at Cincinnati Children's and the study's senior author. "Now we have molecular insights that will allow us to understand specific interactions throughout all stages of kidney development."

Dr. Potter explained this will let researchers analyze kidney abnormalities in mutant mice "in a much more complete and profound way than ever before. Given the mouse's genetic similarities with people, this should help us understand the underpinnings of human disease," he said.

The researchers conducted their multi-step analysis of mouse embryon
'/>"/>

Contact: Nick Miller
nicholas.miller@cchmc.org
513-803-6035
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Know the Myths and Facts About Family Health History: American College of Medical Genetics
2. Impulse control area in brain affected in teens with genetic vulnerability for alcoholism
3. Interleukin Genetics Announces Conference Call and Webcast to Discuss Third Quarter 2008 Business Results
4. Researchers ID Genetic Markers for Esophageal Cancer
5. Genetic disorder sheds light on enzymes role in bone metabolism
6. Penn scientists map molecular regulation of fat-cell genetics
7. Tackling a hard-to-treat childhood cancer by targeting epigenetic changes
8. Tackling Hard-to-treat Childhood Cancer by Targeting Epigenetic Changes
9. Interleukin Genetics to Present at Rodman & Renshaw 10th Annual Healthcare Conference
10. First evidence that prenatal exposure to famine may lead to persistent epigenetic changes
11. If the diabetes has a direct carcinogenetic effect?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... in infertile land, and bear many beans that are ... most legumes have a symbiotic relationship with bacteria, called ... then supply the host plant with ammonia as a ... nodules in their roots. However, if too many root ... of the plants, because the energy cost of maintaining ...
(Date:9/19/2014)... images representing various glosses and then they measured ... They found that a specific population of neurons ... to either the contrast-of-highlight, sharpness-of-highlight, or brightness of ... parameters are used as parameters when the brain ... that different parameters are represented by different populations ...
(Date:9/19/2014)... September 19, 2014 Lifeinsure.biz has ... insurance riders that can be purchased without medical examinations. ... up and make a life insurance policy more advantageous. ... find more about extra options available for a no ... without medical examinations required is simple to purchase, however ...
(Date:9/19/2014)... InventHelp, a leading inventor service company, announces ... has created an accessory designed for use with a stretcher ... transport. This invention is patented. , “Patient ... place until removed, guarding a patient’s head and upper body ... from irritating smoke or rain. The accessory would be pulled ...
(Date:9/19/2014)... York, NY (PRWEB) September 19, 2014 ... Stevie Wonder tickets for his 2014 concert tour. ... In the music business, there are a handful of artists ... Stevie Wonder. Born in Saginaw, MichIgan, Wonder has been a ... During his time in the music business, he has released ...
Breaking Medicine News(10 mins):Health News:Long-distance communication from leaves to roots 2Health News:Neurons express 'gloss' using three perceptual parameters 2Health News:No Medical Exam Life Insurance - Lifeinsure.biz Presents 5 Important Riders! 2Health News:InventHelp® Client Patents “Patient Protector” – Designed to Protect Patients During Transport 2Health News:Stevie Wonder Tickets: Ticket Down Slashes Ticket Prices in Seattle, Boston, New York, Atlanta, Chicago, Detroit, Philadelphia, Toronto, Las Vegas & Oakland 2Health News:Stevie Wonder Tickets: Ticket Down Slashes Ticket Prices in Seattle, Boston, New York, Atlanta, Chicago, Detroit, Philadelphia, Toronto, Las Vegas & Oakland 3
... and Mental Hygiene (DOHMH) has banned at least three herbal ... lead and mercury. // , ,"Though there are no ... Institute of Medicine of the National Academies recommends that certain ... million) of lead and no more than 1 ppm of ...
... lose their beauty - they merely move it from their faces ... very normal girl who was in pursuit of her dreams until ... 19th of September 1999 changed her life. She met with a ... was burnt. She lost her ears, nose, left eyelid and most ...
... to the same chromosome regions which are connected with ... which exists between alcohol consumption and smoking may // ... overlap. Environmental factors also contribute towards alcoholism. Drinking and ... the lead author of the study. As many as ...
... Rogers has won the right to fight for receiving the new ... aggressive type of breast cancer and wants to make sure that ... disease is in its early stage has meant that the primary ... already taken legal recourse for the same. Even Patricia Hewitt, the ...
... in South Australia for every 100,000 people, which is reportedly ... at 11. The amount of Government funding to NGOs which ... the country. The number of mental health disorders in South ... ,The State spending towards mental health has risen by ...
... a research headed by Dr Michael Fenech studied the damage of ... study stated that excess intake of // alcoholic beverages resulted in ... the course of the study, six men aged 21-26 stuck to ... drank 300 millilitres of either complete red wine, red wine with ...
Cached Medicine News:Health News:NY Health Dept Bans 3 Ayurveda Drugs 2Health News:The Looming Controversy Surrounding Facial Transplant 2
(Date:9/19/2014)... Sept. 19, 2014  Over 200 runners participated in ... Benefit the Radiation Oncology Institute (ROI), hosted by Radiation ... Gate Park in San Francisco.  "Donations ... CEO of Radiation Business Solutions, "but at this ... over $70,000 for the ROI this year. This surpasses ...
(Date:9/19/2014)... 2014  CytRx Corporation (Nasdaq: CYTR ), ... today announced that David J. Haen , Vice ... in the Biotech Industry Conference on Friday, September 26 th ... take place at the Millennium Broadway Hotel in ... live and archived webcast of the presentation will be ...
(Date:9/19/2014)... , September 19, 2014 Reductions ... for many years in people with diabetes type 2 ... long term benefits for the kidneys." Australian ... with type 2 diabetes leads to persistent reductions in ... The global study has found that, five ...
Breaking Medicine Technology:Fifth Annual 5K Run for the Future to Benefit the Radiation Oncology Institute Breaks Attendance, Donation Records 2Fifth Annual 5K Run for the Future to Benefit the Radiation Oncology Institute Breaks Attendance, Donation Records 3CytRx to Present at BioCentury's 2014 NewsMakers in the Biotech Industry Conference 2CytRx to Present at BioCentury's 2014 NewsMakers in the Biotech Industry Conference 3ADVANCE-ON Post-trial Observational Study: Blood Pressure Arm and Glucose Arm Results 2ADVANCE-ON Post-trial Observational Study: Blood Pressure Arm and Glucose Arm Results 3
... Systems, Inc. (NASDAQ: DCTH ) announced today that ... agreement for the Delcath Hepatic CHEMOSAT ® Delivery system ... Oncologia ---IEO), a premier European cancer treatment and research center ... the Company will provide the IEO with logistics and clinical ...
... Reportlinker.com announces that a new ... its catalogue: , Frost & ... http://www.reportlinker.com/p0490686/Frost--Sullivan-Speaks-Candidly-with-US-Pharmacists.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Pharmacies_and_Drug_Stores ... feedback provided by a healthcare pharmacist ...
Cached Medicine Technology:Delcath Announces Agreement With European Institute of Oncology for Initial Launch of Hepatic Chemosat Delivery System in the European Union 2Delcath Announces Agreement With European Institute of Oncology for Initial Launch of Hepatic Chemosat Delivery System in the European Union 3Delcath Announces Agreement With European Institute of Oncology for Initial Launch of Hepatic Chemosat Delivery System in the European Union 4Frost & Sullivan Speaks Candidly with U.S. Pharmacists 2Frost & Sullivan Speaks Candidly with U.S. Pharmacists 3
Precision that fits in the palm of your hand and measures down to 125 microns, the Pocket Pachymeter is about 8" X 4" x 2" and really does fit in a lab coat pocket or briefcase....
15 segment Vertical Prism Bar provides 1, 2, 3, 4, 5, 6, 8, 10, 12, 14, 16, 18, 20, 25, 30 PD (Note: 30 PD is on the bar). 4447 xx Vertical Prism Bar....
Valleylab Surgistat II generator provides exceptional performance, reliability, and safety benefits in a compact, easy to use unit....
Sabre 180, 230V, 50Hz is a powerful niche generator....
Medicine Products: