Navigation Links
Genetic basis of high-risk childhood cancer points to possible new drug treatment strategy
Date:1/20/2013

n tumor associated with Li-Fraumeni syndrome. His son later developed low hypodiploid ALL.

"Identification of children with low-hypodiploid ALL and inherited TP53 mutations could help expand the use of life-saving cancer screening," said Linda Holmfeldt, Ph.D., a St. Jude postdoctoral fellow. She and Lei Wei, Ph.D., of the St. Jude Department of Computational Biology and formerly of Pathology, are the study's co-first authors. "Screening helps save lives by finding cancers much earlier when the odds of a cure are greatest," Holmfeldt said.

Investigators also reported deletions involving Ikaros gene family members that are rare in other ALL patients. The genes play a role in normal immune system development. The IKZF3 gene, also known as AIOLOS, was deleted in 13 percent of near haploid ALL patients. IKZF3 was deleted in nearly 53 percent of patients with low hypodiploid ALL.

Despite such differences, when researchers tested a variety of compounds against cells from both subtypes growing in the laboratory, they found compounds that targeted the PI3K pathway inhibited proliferation. Researchers are testing the effectiveness of these drugs in mouse models.


'/>"/>

Contact: Carrie Strehlau
media@stjude.org
901-595-2295
St. Jude Children's Research Hospital
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Your Genetic Secrets May Not Be as Safe as You Think
2. Researchers identify genetic mutation for rare cancer
3. Almost Nuts! a Wisconsin Company Innovates Healthy Snack Foods that are Not Genetically Modified
4. Kidneys Sometimes Removed Needlessly in Patients With Rare Genetic Disorder
5. Study Suggests Genetic Link Between Epilepsy, Migraine
6. U-M sibling study discovers genetic region linked to control of key blood-clotting protein
7. Scientists ID New Genetic Connection for Gout
8. New technique catalogs lymphoma-linked genetic variations
9. A genetic defect in sex cells may predispose to childhood leukemia
10. Cleveland Clinic researcher identifies 2 new genetic mutations associated with Cowden syndrome
11. Drug resistant leukemia stem cells may be source of genetic chaos, Temple scientists find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... Riverside Health System became the first provider of Community- ... and now, in partnership with Williamsburg Landing, will offer its ... Newport News region. , Also known as life care at ... adults who wish to remain in their homes but want ... services as well as control over the cost of long-term ...
(Date:7/11/2014)... scientists have been trying to unravel mechanisms that guide ... that generate all blood cells including our immune system. ... because they can only be found in the bone ... a culture dish. Now a group of scientists from ... (Technische Universitt Dresden) was able to generate a mouse ...
(Date:7/11/2014)... 2014 WWTrek Human Outreach Project ... Community in Tanzania. Opened in 2012, the KKC is now ... cows. HOP Founder, Dean Cardinale, started the KKC to create ... orphaned children he encountered while running treks on Tanzania's Mount ... who have all made astounding progress in school over the ...
(Date:7/11/2014)... Francisco shows that an "expressive therapy" group intervention ... with HIV disclose their health status and improves ... quality of their relationships., "Medication alone is totally ... Machtinger, MD, director of the Women,s HIV Program ... are on effective antiretroviral therapy but far too ...
(Date:7/11/2014)... 2014 Recently, iFitDress.com, a leading online ... has released its new collection of evening dresses ... has announced that all these beautiful items are provided ... of the special offer is July 22. , ... pay close attention to customer satisfaction. On the company’s ...
Breaking Medicine News(10 mins):Health News:Riverside and Williamsburg Landing Partner to Offer First of Its Kind Service to Virginians Who Want to Age in Place 2Health News:Riverside and Williamsburg Landing Partner to Offer First of Its Kind Service to Virginians Who Want to Age in Place 3Health News:Riverside and Williamsburg Landing Partner to Offer First of Its Kind Service to Virginians Who Want to Age in Place 4Health News:Opening-up the stem cell niche 2Health News:Human Outreach Project Sees Incredible Progress in the Kilimanjaro Kids Community 2Health News:'Expressive therapy" intervention assists women living with HIV 2Health News:Worldwide Chic Ladies Can Buy Cheap Evening Dresses at iFitDress.com 2
... Windows Vista, Adobe Flash 10 and high-availability failover support. , ... ... today announced the release of the latest version of the industry ... of CoolSign further builds on its existing enterprise-based, robust feature set, ...
... 2009 As Zimbabwe continues to confront a,cholera ... a new,World Vision project supported by the Procter ... Drinking Water Program is underway, providing Zimbabweans with ... families and their,communities. , ...
... a limited edition beauty bag filled with products as ... Wash. and NEW YORK, Feb. 24 Beauty.com, Inc., ... DSCM ), announces Shoshanna Gruss as their ... program. Beginning February 25th, the exclusive Shoshanna-designed beauty case ...
... Them Crazy While They Work...30,000+ Dentists Converge in Chicago ... being issued by the Chicago Dental Society:Who: The ... members to find out some wacky, unusual, and just ... their chair.As we countdown to CDS,s annual Midwinter Meeting, ...
... dental techniques, , , TUESDAY, Feb. 24 (HealthDay News) -- ... and the development of skin and the nervous system ... University researchers have found. , Their discovery about the ... methods of repairing damaged enamel and preventing cavities, restoring ...
... promiscuity, experts stress, , , TUESDAY, Feb. 24 (HealthDay News) -- ... have sex, but a new study provides another suggestion that ... and teenage sexual activity. , The findings indicate that ... more likely to copy or emulate what they hear," said ...
Cached Medicine News:Health News:Procter & Gamble and World Vision Equip and Empower Zimbabweans in Fight Against Cholera 2Health News:Procter & Gamble and World Vision Equip and Empower Zimbabweans in Fight Against Cholera 3Health News:NY Fashion Designer Shoshanna Creates Exclusive Spring Bag for Beauty.com 2Health News:NY Fashion Designer Shoshanna Creates Exclusive Spring Bag for Beauty.com 3Health News:Top 5 Most Annoying Dental Patient Behaviors 2Health News:Scientists Find Gene for Tooth Enamel 2Health News:'Degrading' Lyrics Linked to Teen Sex 2Health News:'Degrading' Lyrics Linked to Teen Sex 3
(Date:7/11/2014)... 11, 2014 On Thursday, ... 0.52%, the Dow Jones Industrial Average finished the day 0.42% ... down 0.41%. The losses were broad based as eight out ... 500 Health Care Sector Index ended the day at 711.88, ... last one month. Investor-Edge has initiated coverage on the following ...
(Date:7/11/2014)... July 11, 2014 Neurelis, Inc. ("Neurelis") today ... end the option held by Biotie to purchase Neurelis, ... of NRL-1 (intranasal diazepam) for pediatric and adult epilepsy ... the past year, Biotie has advanced the development program ... the pivotal clinical work required for NDA submission to ...
(Date:7/10/2014)... -- Integrated Silicon Solution, Inc. (Nasdaq: ISSI ... solutions, today announced that it will host its earnings ... a.m. Pacific Time (10:00 a.m. Eastern Time) to discuss ... quarter ended June 30, 2014. To access ... a.m. Pacific time on July 24, 2014.  The participant ...
Breaking Medicine Technology:Health Care Equipment Equities Movers and Shakers -- Research on Covidien, Baxter, DexCom, and Boston Scientific 2Health Care Equipment Equities Movers and Shakers -- Research on Covidien, Baxter, DexCom, and Boston Scientific 3Health Care Equipment Equities Movers and Shakers -- Research on Covidien, Baxter, DexCom, and Boston Scientific 4Neurelis Regains Rights to Intranasal Diazepam Program 2Neurelis Regains Rights to Intranasal Diazepam Program 3
... Inc. (Nasdaq: BIOD ) will issue its third ...  Following the release of the company,s financial results, Biodel,s senior ... and provide an update on the company,s progress.August 4, 2011 ... be distributed4:15 pm EDT: , Conference call participants should dial:+1 ...
... Reportlinker.com announces that a new market research ... Insulin- Western Europe ... package contains 14 insulin market analyses from ... Denmark, Finland, France, Germany, Ireland, Italy, the ...
Cached Medicine Technology:Insulin- Western Europe 2
... Alert Detection Reagents provide molecular labs a ... assays. By using our MGB technology, combined ... is now able to provide molecular labs ... sequences of specific organisms or genetic mutations ...
... latest and most advanced fecal occult blood ... An immunochemical FOBT (iFOBT) with high specificity ... to detect bleeding associated with more cancers ... of its superior specificity for lower GI ...
AUTION ELEVEN is the eleventh model of AUTION series which is ideal for use in small-to-medium-sized hospitals and clinics with its smart design and features....
Drugs of Abuse (DoA) Array is used for in-vitro diagnostic tests for the qualitative determination of the parent molecule and metabolites of drugs in human urine....
Medicine Products: