Navigation Links
Genetic basis of high-risk childhood cancer points to possible new drug treatment strategy
Date:1/20/2013

were in remission. The study included whole-genome sequencing of the entire cancer and normal genomes of 20 patients with near haploid or low hypodiploid subtypes. For another 20 patients, investigators deciphered just DNA involved in protein production. Researchers also screened cancer cells from 117 adult ALL patients, including 11 with the low hypodiploid subtype.

The whole genome sequencing was done in conjunction with the St. Jude Children's Research Hospital Washington University Pediatric Cancer Genome Project. The project has sequenced the complete normal and cancer genomes of more than 600 children and adolescents with some of the most aggressive and least understood cancers.

Near haploid ALL was characterized by alterations in six genes and increased activity in key pathways that help regulate cell division and development. Disruption of these pathways, known as Ras and PI3K, has been linked to other cancers. The changes were found in 71 percent of near haploid ALL patients and included deletion of the NF1 gene. The gene had not previously been linked to high-risk leukemia. Other alterations involved the genes NRAS, KRAS, MAPK1, FLT3 and PTPN11.

Low hypodiploid ALL in both adults and children was linked to mutations in the TP53 tumor suppressor gene. The gene was altered in 91 percent of pediatric patients with the ALL subtype and in 10 of the 11 adults with low hypodiploid ALL included in the study. Other common alterations involved RB1, another tumor suppressor gene.

About 38 percent of children with low hypodiploid ALL also carried TP53 abnormalities in non-cancerous blood cells. The mutations included many previously linked to Li-Fraumeni syndrome, which is characterized by changes in TP53.

Further evidence linking low hypodiploid ALL to Li-Fraumeni syndrome came when researchers found the same TP53 mutation in two generations of the same family. The father was 31 years old when he was found to have a brai
'/>"/>

Contact: Carrie Strehlau
media@stjude.org
901-595-2295
St. Jude Children's Research Hospital
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Your Genetic Secrets May Not Be as Safe as You Think
2. Researchers identify genetic mutation for rare cancer
3. Almost Nuts! a Wisconsin Company Innovates Healthy Snack Foods that are Not Genetically Modified
4. Kidneys Sometimes Removed Needlessly in Patients With Rare Genetic Disorder
5. Study Suggests Genetic Link Between Epilepsy, Migraine
6. U-M sibling study discovers genetic region linked to control of key blood-clotting protein
7. Scientists ID New Genetic Connection for Gout
8. New technique catalogs lymphoma-linked genetic variations
9. A genetic defect in sex cells may predispose to childhood leukemia
10. Cleveland Clinic researcher identifies 2 new genetic mutations associated with Cowden syndrome
11. Drug resistant leukemia stem cells may be source of genetic chaos, Temple scientists find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... both breast cancer relapses and responses to chemotherapy, ... newly found marker could help doctors classify each ... that is more effective. The discovery was a ... Molecular and Cell Biology (IMCB), and the Cancer ... National University of Singapore (NUS). , Despite advancements ...
(Date:8/20/2014)... 20, 2014 It’s no secret that ... to the National Institute on Drug Abuse, nearly 24 ... What’s even more alarming is the fact that the ... decade. , Those locked in a struggle with substance ... out. But now, the newly-redesigned AbuseTreatmentCenters.net has released updated ...
(Date:8/20/2014)... (PRWEB) August 20, 2014 Little Green ... Really Little Green Pouch —to meet growing demand ... babies and toddlers homemade foods. , “The Real ... Pouch co-founder Maggie Crawford. She continues, “Parents want ... limit exposure to things like pesticides and hidden ingredients ...
(Date:8/20/2014)... Botanica Day Spa ... the new and popular stem cell line from ... and wrinkles and naturally repairs the skin. The ... new service by offering clients a complimentary dermaplaning ... facial. , Pevonia® continues to be a global ...
(Date:8/20/2014)... News) -- Leaving the car at home and getting to ... your health, a new study indicates. Researchers looked at ... 76 percent of men and 72 percent of women drove ... women used public transit, and 14 percent of men and ... drove to work weighed more and had higher levels of ...
Breaking Medicine News(10 mins):Health News:Novel gene predicts both breast cancer relapse and response to chemotherapy 2Health News:Re-Launched AbuseTreatmentCenters.net Offering New List of Substance Abuse Resources 2Health News:Little Green Pouch Launches New Product to Help Health-conscious Parents Reduce Babies’ Eco-footprint 2Health News:New Stem Cell Facial Unveiled at Botanica Day Spa 2Health News:New Stem Cell Facial Unveiled at Botanica Day Spa 3Health News:Want to Stay Slim? Leave the Car at Home 2
... People with mesothelioma — a form of cancer associated with ... with a combination// of two cancer drugs, a large multicenter ... cancer that occurs in the lining of the lungs, heart ... no known cure. ,In the study, patients receiving ...
... in Vitamin D3 levels control the body’s innate immune ... ,Richard L. Gallo, M.D., Ph.D., professor of medicine ... Dermatology section of the Veterans Affairs San Diego Healthcare ... the body’s vitamin D3 and infectious disease have emerged ...
... now. Hitherto, there used to be unsubstantiated suggestions to ... effect now from authoritive sources: a study by university ... postdoctoral researcher in the Berkeley Olfactory Research Program, who ... some insects, human secretions too influence the physiology of ...
... spread awareness of health issues like stroke// , prostate cancer ... as vital as any doctor, drug or diagnostic test. ... the American Stroke Association's International Stroke Conference suggests beauty shops ... strokes. ,In the study, researchers gave lessons on ...
... more stress than boys, especially in their interpersonal relationships//, ... by mid puberty (age 13 or so) more girls ... by the online edition of Daily Mail, says girls ... than boys. ,Benjamin L. Hankin, assistant professor ...
... Two scientists have come out strongly against the NHS's ... in the age group 25 to 29, leaving// out women ... Consultant cytopathologists Amanda Herbert, from Guy's and St. Thomas' NHS ... Hallamshire Hospital in Sheffield, girls have started having sex at ...
Cached Medicine News:Health News:Chemo Combination Improves Survival in Asbestos-Related Cancer 2Health News:Chemo Combination Improves Survival in Asbestos-Related Cancer 3Health News:Vitamin D3 Protects Skin from Harmful Microbes 2Health News:The Secretions Influence Opposite Sex 2Health News:Beauticians and Barbers can Do More Than Their Services 2Health News:Extend Cervical Smears to Younger Women, Insist Specialists 2
(Date:8/20/2014)... , Aug. 20, 2014 ... research report is available in its ... Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing ... http://www.reportlinker.com/p01618925/The-Market-for-Hospital-Acquired-Infection-Control-Sterilization-Disinfection-Testing-and-Treatment.html Given the ... (HAIs), demand has increased for solutions ...
(Date:8/20/2014)... 20, 2014 Reportlinker.com announces that a ... catalogue: The Impact of Healthcare Reform ... http://www.reportlinker.com/p01618927/The-Impact-of-Healthcare-Reform-PPACA-On-the-US-IVD-Industry.html The "Patient ... complex legislation that affects virtually every aspect of ... beginning to take effect now. IVD manufacturers who ...
(Date:8/20/2014)... 2014 Reportlinker.com announces that a ... its catalogue: Personal Accident and ... Opportunities to 2018 ... provides in depth market analysis, information and ... health insurance segment, including: - The French ...
Breaking Medicine Technology:The Market for Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing and Treatment) 2The Market for Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing and Treatment) 3The Market for Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing and Treatment) 4The Market for Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing and Treatment) 5The Market for Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing and Treatment) 6The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 2The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 3The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 4The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 5The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 6Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 2Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 3Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 4Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 5Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 6Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 7Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 8Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 9Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 10Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 11Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 12Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 13Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 14Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 15Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 16Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 17Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 18Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 19Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 20Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 21Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 22Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 23
... 28 Danaher Corporation (NYSE: DHR ) announced ... Comas will be presenting at the Goldman Sachs Global Industrials ... at 10:15 a.m. EDT. The company also announced that President ... presenting at the Robert W. Baird Industrial Conference in Chicago, ...
... The U.S. Food and Drug Administration today ... of adults with schizophrenia. (Logo: ... ) Schizophrenia affects about 1 ... and older, in a given year. The most ...
Cached Medicine Technology:FDA Approves Latuda to Treat Schizophrenia in Adults 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: