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Genetic and behavioral differences add to prostate cancer disparities
Date:11/28/2007

n-American men are 22 percent more likely to hold fatalistic beliefs about cancer and 60 percent less likely to possess the religious coping skills that could sustain them through cancer therapy, Odedina says. Among African-American men and women, fatalistic perspectives have also been reported to affect cervical cancer, breast cancer, colorectal cancer and fecal occult blood testing, she says.

Although the impact of religion and spiritualism on cancer prevention or detection has not been well documented in the literature, it has been suggested that it may deter women from seeking treatment for breast cancer, Odedina says.


Association between PSA and leptin, adiponectin, HbA1c, or C-peptide among African-American and Caucasian men. Abstract No. A-33:

Obesity and diabetes might mask the onset of prostate cancer in African American men, making it difficult to detect early-stage and treatable prostate cancer in a population of men already prone to aggressive cancer, according to researchers at Vanderbilt University. Their findings examine the link between prostate-specific antigen (PSA) a blood marker which at elevated levels indicates the presence of prostate cancer and biological markers for obesity and diabetes.

African-American men, among all racial groups, are more likely to be diagnosed with prostate cancer at an advanced stage and are also more likely to die from prostate cancer, said Jay H. Fowke, Ph.D., M.P.H., an assistant professor of Medicine and cancer epidemiologist at Vanderbilt-Ingram Cancer Center.

According to Fowke, obese men are also more likely to present with prostate cancer at an advanced stage. Most prostate cancer is diagnosed in response to a PSA test, and a high body mass index (BMI) often corresponds with lower blood PSA levels.

Diabetes and metabolic disturbances associated with insulin regulation are more common among African-Americans compared to Caucasian
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Contact: Greg Lester
greg.lester@aacr.org
267-646-0554
American Association for Cancer Research
Source:Eurekalert

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