Navigation Links
Genetic analysis may predict risk of invasive bladder cancer
Date:4/20/2009

DENVER Genetic variations in the inflammation pathway may predict who would respond to Bacillus-Calmette-Guerin (BCG) treatment and who might experience a recurrence among patients with non-muscle invasive bladder cancer, according to data presented at the American Association for Cancer Research 100th Annual Meeting 2009.

"Our goal is to use genetic information like this to create a genetic blueprint for this disease, which currently recurs in about 70 percent of patients despite initial successful therapy," said Xifeng Wu, M.D., Ph.D., senior author of the study and a professor in the department of epidemiology at the University of Texas M.D. Anderson Cancer Center, where the research was conducted.

Hushan Yang, Ph.D., a postdoctoral fellow at M. D. Anderson and the first author of this study, and colleagues evaluated a panel of 59 single nucleotide polymorphisms in 35 major inflammation genes in all participants that had been treated with BCG therapy, the current treatment standard for non-muscle invasive bladder cancer.

If a patient had a genotype containing the variant allele of the iNOS gene, there was a significant reduction in the risk of recurrence compared with those patients who did not have this variance.

"Survival associated with this variance was 96.7 months compared with 47.0 months among patients with the wild-type gene," Yang said.

In a further analysis, Yang and colleagues calculated a variance combination to identify those patients at high risk for recurrence. The overall median recurrence-free survival time in this group was only 13.5 months compared with more than 96.7 months, or indefinitely, in the low-risk group.

"These genes can be measured through simple blood tests," said Wu. "Once we identify the patients at high risk for recurrence we can adjust their therapy and followup accordingly."


'/>"/>

Contact: Jeremy Moore
Jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Page: 1

Related medicine news :

1. Many Parents Share Genetic Test Findings With Kids
2. Genetic predisposition increases childhood asthma risk
3. New Alzheimers findings: High stress and genetic risk factor lead to increased memory decline
4. Test Spots Genetic Damage Done by Smoking
5. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
6. Scientists highlight benefits of genetic research in sport, but warn of ethical concerns
7. Genetics Hold Promise, Challenges for Cancer Care
8. Researchers genetically engineer micro-organisms into tiny factories
9. Study Questions Genetic Screening for Treatable Diseases
10. Researchers provide genetic associations from a genome-wide scan for cardiovascular disease traits
11. Genetic variation affects smoking cessation treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/16/2017)... ... ... Maury Regional Health has announced a large-scale adoption of AccuVein vein visualization ... Regional Medical Center is making vein visualization part of their standard of care. , ... importantly, helps our staff members locate a vein that will provide good access to ...
(Date:8/16/2017)... ... August 16, 2017 , ... A global leader in the treatment ... clinics in all 29 Indian states—bringing the country one step closer to eliminating clubfoot ... the nonprofit organization is on track to enroll 10,000 children in the clubfoot treatment ...
(Date:8/16/2017)... ... , ... Fusion Flix Inc., a Telly Award Winning, Non Profit Corporation has ... viewers in a partnership with the Amazon Video Direct Streaming Distribution Platform. , Their ... Ray disc in 2018. Proceeds will be going to further health research. , ...
(Date:8/16/2017)... (PRWEB) , ... August 16, 2017 , ... TopConsumerReviews.com recently ... Lab Testing . , The healthcare industry in the United States has undergone ... are the days of needing to have a doctor’s order to get a blood ...
(Date:8/16/2017)... , ... August 16, 2017 , ... First Choice ... States, named Dr. Douglas J. Harrison, as the new Medical Director of its Sienna ... new facility Medical Director of our Sienna Plantation location,” said Dr. Michael (Derek) Caraway, ...
Breaking Medicine News(10 mins):
(Date:8/15/2017)... , Aug. 15, 2017  AOTI Inc. announced today that its ... Inc., has recently opened a New York City Office in ... of its unique Topical Wound Oxygen (TWO 2 ) homecare therapy. ... Accreditation Commission for Health Care (ACHC) under the company,s DMEPOS accreditation ... ...
(Date:8/8/2017)... Israel, Aug. 8, 2017  BioLineRx Ltd. (NASDAQ/TASE: BLRX), ... today reports its financial results for the second quarter ... during the second quarter 2017 and to date: ... clinical development programs for the Company,s lead project, BL-8040: ... pivotal study with BL-8040 as novel stem cell mobilization ...
(Date:8/7/2017)... Mich. , Aug. 7, 2017 Diplomat Pharmacy, ... of Joel Saban as president, effective Aug. 7, ... Urick has decided to pursue other interests and will ... "During his tenure, Paul has served us in multiple leadership ... Specialty Pharmacy in Jun. 2015 and has provided decisive, strategic ...
Breaking Medicine Technology: