Navigation Links
Genetic analysis may predict risk of invasive bladder cancer
Date:4/20/2009

DENVER Genetic variations in the inflammation pathway may predict who would respond to Bacillus-Calmette-Guerin (BCG) treatment and who might experience a recurrence among patients with non-muscle invasive bladder cancer, according to data presented at the American Association for Cancer Research 100th Annual Meeting 2009.

"Our goal is to use genetic information like this to create a genetic blueprint for this disease, which currently recurs in about 70 percent of patients despite initial successful therapy," said Xifeng Wu, M.D., Ph.D., senior author of the study and a professor in the department of epidemiology at the University of Texas M.D. Anderson Cancer Center, where the research was conducted.

Hushan Yang, Ph.D., a postdoctoral fellow at M. D. Anderson and the first author of this study, and colleagues evaluated a panel of 59 single nucleotide polymorphisms in 35 major inflammation genes in all participants that had been treated with BCG therapy, the current treatment standard for non-muscle invasive bladder cancer.

If a patient had a genotype containing the variant allele of the iNOS gene, there was a significant reduction in the risk of recurrence compared with those patients who did not have this variance.

"Survival associated with this variance was 96.7 months compared with 47.0 months among patients with the wild-type gene," Yang said.

In a further analysis, Yang and colleagues calculated a variance combination to identify those patients at high risk for recurrence. The overall median recurrence-free survival time in this group was only 13.5 months compared with more than 96.7 months, or indefinitely, in the low-risk group.

"These genes can be measured through simple blood tests," said Wu. "Once we identify the patients at high risk for recurrence we can adjust their therapy and followup accordingly."


'/>"/>

Contact: Jeremy Moore
Jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Page: 1

Related medicine news :

1. Many Parents Share Genetic Test Findings With Kids
2. Genetic predisposition increases childhood asthma risk
3. New Alzheimers findings: High stress and genetic risk factor lead to increased memory decline
4. Test Spots Genetic Damage Done by Smoking
5. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
6. Scientists highlight benefits of genetic research in sport, but warn of ethical concerns
7. Genetics Hold Promise, Challenges for Cancer Care
8. Researchers genetically engineer micro-organisms into tiny factories
9. Study Questions Genetic Screening for Treatable Diseases
10. Researchers provide genetic associations from a genome-wide scan for cardiovascular disease traits
11. Genetic variation affects smoking cessation treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... Dickinson Insurance ... insurance and financial preparation services, is providing an update on a charitable event ... Rock City Rescue is a locally recognized nonprofit that provides shelter and care ...
(Date:10/13/2017)... ... October 13, 2017 , ... The International Association of ... of excellence for the field of eating disorders, announces the opening of early ... in Orlando, Florida at the Omni Resort at ChampionsGate. , The ...
(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton Lakes , which ... evacuation of the facility as part of a disaster drill on October 3rd. , ... and Shelton City Emergency Manager, as well as the Connecticut Long Term Care ...
(Date:10/13/2017)... ... ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out many kids this ... by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting kids excited about ... ages; it is a non-competitive, non-timed event, which is all about having fun and ...
(Date:10/13/2017)... ... 13, 2017 , ... “The Journey: From the Mountains to the Mission Field”: ... souls in the Philippines. “The Journey: From the Mountains to the Mission Field” is ... Bible. She has taught all ages and currently teaches a class of ladies at ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... the Centers for Disease Control and Prevention (CDC), influenza vaccination should ... helping communities across Massachusetts , Connecticut ... shots through the end of the month. *Some exclusions apply ... ... is by the end of October, according to the Centers for Disease ...
(Date:10/2/2017)... Labs announces the European launch of their new low volume, high ... in Cambridge, U.K on October 4th. The ... with unprecedented speed and sensitivity while using far less sample volume ... ... ...
(Date:9/27/2017)... Sept. 27, 2017  DarioHealth Corp. (NASDAQ: DRIO), a leading global digital ... its MyDario product is expected to appear on The Dr. Oz Show ... Oz Show airs in your area: http://www.doctoroz.com/page/where-watch-dr-oz-show ... The nine-time Emmy award-winning, The Dr. Oz Show kicked off ... The segment features ...
Breaking Medicine Technology: