Navigation Links
Genetic abnormalities in benign or malignant tissues predict relapse of prostate cancer
Date:5/6/2012

creasing at a slow rate, doubling time greater than 15 months; and a third with no relapse more than five years after surgery. Three commercially available prostate cancer cell lines were also tested to validate the results.

Deletions of large segments of specific chromosomes occurred with high frequency, whereas amplification of other chromosomes occurred in only a subset of prostate cancer samples. Similar amplification and deletion of the same regions also occurred in benign prostate tissue samples adjacent to the cancer. Prostate cancer patients' blood was found to contain significant CNVs. Most were not unique and overlapped with those of prostate cancer samples.

Using gene-specific CNV from tumor, the model correctly predicted 73% of cases for relapse and 75% of cases for short PSA doubling time. The CNV model from tissue adjacent to the prostate tumor correctly predicted 67% of cases for relapse and 77% of cases for short PSA doubling time. Using median-size CNV from blood, the genome model correctly predicted 81% of the cases for relapse and 69% of the cases for short PSA doubling time.

Dr. Luo notes that there are several potential clinical applications using CNV tests. "For a patient diagnosed with prostate cancer, CNV analysis done on blood or normal tissues would eliminate the need for additional invasive procedures to decide a treatment mode. For a patient already having a radical prostatectomy, CNV analysis on the tumor or blood sample may help to decide whether additional treatment is warranted to prevent relapse. Despite some limitations, including the need for high quality genome DNA, CNV analysis on the genome of blood, normal prostate, or tumor tissues holds promise to become a more efficient and accurate way to predict the behavior of prostate cancer."


'/>"/>

Contact: David Sampson
ajpmedia@elsevier.com
215-239-3171
Elsevier Health Sciences
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Some women may be genetically predisposed to smoking-related hot flashes
2. Genetically modified T cell therapy shown to be safe, lasting in decade-long study of HIV patients
3. Moffitt researcher awarded GE grant to develop tool to detect breast cancer metastasis genetic risks
4. Research Gets Closer to Genetic Roots of Glaucoma
5. Genetic variants, tobacco exposure and lung cancer risk
6. Study of half siblings provides genetic clues to autism
7. Certain Genetic Regions May Be Tied to Osteoporosis
8. Head, Body Lice Are Genetically Very Similar
9. 2 genetic deletions in human genome linked to the development of aggressive prostate cancer
10. IntegraGen launches ARISk test, a genetic screening tool for autism in high-risk children
11. Genetic causes found in nearly 1 in 5 patients with dilated cardiomyopathy heart failure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2015)... ... August 29, 2015 , ... "I ... from Miller Place, N.Y. "I specialize in manual therapy, and my invention will ... can be used for additional muscle dysfunction throughout the body." , They developed ...
(Date:8/29/2015)... (PRWEB) , ... August 29, 2015 , ... Next weekend ... of summer (which astronomically, officially ends on September 22nd this year). For IT security ... security hangovers linger on which could prove far more costly than a simple headache. ...
(Date:8/29/2015)... ... August 29, 2015 , ... Vascular Health ... and sell Arterosil and Arterosil HP, and that all claims and counterclaims have ... Health Sciences, LLC (VHS) in the United States District Court for the Southern ...
(Date:8/28/2015)... ... August 28, 2015 , ... The Kentucky State Department of ... for the position they are applying for, they are unable to pass the initial ... considering altering drug testing policies in order to be able to hire long-term, skilled ...
(Date:8/28/2015)... ... ... As reported by Medical Daily on August 22 , Cellfina, a non-invasive ... two years, the longest of any cellulite reduction system currently on the market. ... solution for their cellulite, according to Dr. Robert Weiss, director of the premier MD ...
Breaking Medicine News(10 mins):Health News:Inventors and InventHelp Clients Develops Tension Reliever (LGI-1951) 2Health News:Business Cyber Security – Come Out of the Summer with a Clean Slate 2Health News:Business Cyber Security – Come Out of the Summer with a Clean Slate 3Health News:Business Cyber Security – Come Out of the Summer with a Clean Slate 4Health News:Hiring Obstacles: Drug Abuse a Problem for Workforce 2Health News:Hiring Obstacles: Drug Abuse a Problem for Workforce 3Health News:Hiring Obstacles: Drug Abuse a Problem for Workforce 4Health News:Maryland Dermatologists Discuss Non-Invasive Cellulite Reduction System Cellfina Receiving 2-Year FDA Clearance 2Health News:Maryland Dermatologists Discuss Non-Invasive Cellulite Reduction System Cellfina Receiving 2-Year FDA Clearance 3
... survey of businesses that looks at their preparations for ... Health (HSPH) researchers found that only one-third believe they ... half their workforce were absent for two weeks due ... believe they could avoid such problems for one month ...
... In a new report, University of Illinois professor Barbara H. Fiese ... promote family mealtimes as a matter of public policy. "There ... protecting their families as taking 18 to 20 minutes to eat ... week," said Fiese, a U of I professor of human development ...
... WASHINGTON, Sept. 9 The Henry M. Jackson Foundation ... Tug McGraw Foundation (TMF) and Grammy Award-winning country music stars Tim ... from the Frontlines to the Homefront ." The presenting sponsor of ... Country United is a two-day event dedicated to supporting ...
... , BOSTON, Sept. 9 A recent study ... of laboratory use and confinement. Developmental Context Effects on ... the September issue, Vol. 45 (5), of the American Psychological ... , , (Photo: http://www.newscom.com/cgi-bin/prnh/20090909/DC72238 ) , ...
... , , , ... the global anti-aging skincare market approached $15 billion(1), with 32 ... many over-the-counter products are claiming to achieve comparable benefits as ... to grow, but FDA-approved prescription products with rigorous efficacy and ...
... Workforce Prescriptions ("WRX") announced on Tuesday the launch of the Paradigm ... by a private endowment, developed to honor hospitals that have gone ... without resorting to workforce reductions or dramatic top-down mandates. , ... the paradigm shift in understanding required to see that the number ...
Cached Medicine News:Health News:Four-fifths of businesses foresee problems maintaining operations if H1N1 flu outbreak 2Health News:Four-fifths of businesses foresee problems maintaining operations if H1N1 flu outbreak 3Health News:Four-fifths of businesses foresee problems maintaining operations if H1N1 flu outbreak 4Health News:U of I acientist: Public policy should promote family mealtimes 2Health News:U of I acientist: Public policy should promote family mealtimes 3Health News:Tim McGraw and Faith Hill Lead Country United Effort to Benefit Military Medicine 2Health News:Tim McGraw and Faith Hill Lead Country United Effort to Benefit Military Medicine 3Health News:Chimpanzees Suffer Psychologically Like Humans 2Health News:Chimpanzees Suffer Psychologically Like Humans 3Health News:Leading Anti-Aging Prescription RENOVA(R) Continues To Deliver Maximum Results 2Health News:Leading Anti-Aging Prescription RENOVA(R) Continues To Deliver Maximum Results 3Health News:WRX Launches National Labor Efficiency Quality Award 2Health News:WRX Launches National Labor Efficiency Quality Award 3
(Date:8/28/2015)... SAN FRANCISCO, Calif. , Aug. 28, 2015 /PRNewswire/ ... for the treatment of cancer, today announced the filing ... U.S. Securities and Exchange Commission (SEC) relating to a ... number of shares to be offered and the price ... CytomX intends to list its common stock under the ...
(Date:8/28/2015)... , Aug. 28, 2015 ... the addition of the "Investigation Report on China,s ... Developed by Roche under the trade name of ... the world. In Feb.26, 2010, it was approved by ... available in China all come ...
(Date:8/28/2015)... , Aug. 28, 2015  Today, in final ... (CDC) Contact Lens Health Week, 1-800 Contacts is sharing ... found that contact lens wearers who do not properly ... risk for eye infections. Most contact ... lenses, but a clean lens case is sometimes overlooked.  ...
Breaking Medicine Technology:CytomX Files Registration Statement for Proposed Initial Public Offering 2Investigation Report on China's Bevacizumab Market 2015-2019 21-800 Contacts Shares Tips on How to Clean Lens Cases 2
... WESTON, Fla., Jan. 14, 2011 American Scientific ... (Pink Sheets: ASFX ) wishes to announces that ... is available at www.sec.gov , has been declared effective ... Registration Statement means that the Company will commence reporting of ...
... Research Institute (IDRI) today announced it has received a ... Foundation for "Chemical genomics for the identification of targets ... is to identify new leads and new drug targets ... of producing new drugs to treat tuberculosis (TB). The ...
Cached Medicine Technology:American Scientific Resources, Inc. Announces S-1 Registration Statement Effective; Commences Public Reporting Requirements 2IDRI Awarded Grant from Bill and Melinda Gates Foundation to Identify Candidates for Novel TB Drugs 2
Triangular 0.5 mm angled tip with 4 mm flat surface. Round knurled handle with dull finish. Tip angle: 130o....
Triangular 0.5 mm angled tip with 4 mm flat surface. Round knurled handle with dull finish. Tip angle: 110o. Most popular size or model....
25 gauge cannula. 2 mm vertical spatula tip with opening on right side. 10 mm from tip to bend. Polished finish....
Angled blade and flat serrated handle with polished finish. Blade: 1 mm x 10 mm....
Medicine Products: