Navigation Links
Genetic Trait May Predict Cocaine Sensitivity

TUESDAY, Dec. 28 (HealthDay News) -- A new study suggests that many white people carry a genetic trait that boosts the risk they'll develop an extreme and possibly deadly cocaine habit.

The trait appears to triple the odds of becoming susceptible to severe cocaine abuse that leads to death from an overdose, compared to non-carriers.

Researchers found signs of the genetic variation in more than 40 percent of brain samples taken from whites who abused cocaine. It was in just 19 percent of whites who didn't take drugs.

Overall, the genetic variant showed up in one in five samples from whites in the control group (and one in two to three samples in the cocaine overdose group), compared to one in eight African Americans, in whom the variant is less common.

The variations affect a neurotransmitter called dopamine that plays a role in helping the brain to feel euphoria when people take cocaine.

"We now have both good biological rationale and clinical association showing that this has an impact on the way cocaine abuse might progress or might be initiated," said study senior author Wolfgang Sadee, professor of pharmacology and director of the Program in Pharmacogenomics at Ohio State University, in a university statement.

"We have found a frequent variant in one of the key candidate genes that can affect cocaine abuse, but more importantly, it also opens the avenue to explore how this variant affects response to therapies for a variety of psychiatric disorders that involve dopamine."

More research is needed before the gene variants could be considered a marker for cocaine sensitivity, the researchers said.

The study is published online in the journal Neuropsychopharmacology.

More information

Learn more about cocaine from the U.S. National Library of Medicine.

-- Randy Dotinga

SOURCE: Ohio State University, news release, December 2010

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Parents favor genetic testing for melanoma in their children
2. Genetic trait could triple odds of whites susceptibility to heavy cocaine abuse
3. MRI scans reveal brain changes in people at genetic risk for Alzheimers
4. deCODE discovers genetic markers that improve the power of PSA testing for detecting prostate cancer
5. Scientists Spot Genetic Areas Key to Embryonic Development
6. Genetic Research Sheds Light on Adrenal Gland Tumor Risk
7. Rare Genetic Syndrome May Increase Colon Cancer Risk
8. Chinese Study Suggests New Way to Test for Genetic Diseases
9. New discovery prevents symptoms of rare genetic disorder
10. Genetic mutations associated with increased PSA and prostate cancer
11. Novel genetic mutation that causes the most common form of eye cancer discovered
Post Your Comments:
Related Image:
Genetic Trait May Predict Cocaine Sensitivity
(Date:10/13/2017)... ... 2017 , ... Ellevate Network, the leading network for professional women, brought together ... equality at their inaugural Summit in New York City in June. The event was ... of over 3 million. To watch the Mobilize Women video, click here . ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... viewers the lowdown on sciatica in a new episode of "Success Files," which ... current events and innovation and investigates each subject in-depth with passion and integrity. ...
(Date:10/13/2017)... ... 13, 2017 , ... “America On The Brink”: the Christian history of the ... is the creation of published author, William Nowers. Captain Nowers and his wife, ... he spent thirty years in the Navy. Following his career as a naval ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and fastest ... to open a flagship location in Covington, LA at 401 N. U.S. Highway 190, ... next to Office Depot in the Holiday Square shopping center. Its location allows it ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of Medical Informatics (ACMI) ... FACMI, during the Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s ... Morris F. Collen, a pioneer in the field of medical informatics, this prestigious award ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... NEW YORK , Sept. 27, 2017  DarioHealth Corp. (NASDAQ: ... data solutions, today announced that its MyDario product is expected to appear ... listings for when The Dr. Oz Show airs in your area: ... The nine-time Emmy award-winning, The ... ...
(Date:9/23/2017)... , Sept. 22, 2017 Janssen Biotech, ... complete response letter from the U.S. Food and Drug ... approval of sirukumab for the treatment of moderately to ... indicates additional clinical data are needed to further evaluate ... to severely active RA. ...
(Date:9/19/2017)... ARBOR, Mich. , Sept. 19, 2017 HistoSonics, Inc., a venture-backed medical device ... precise destruction of targeted tissues, announced three leadership team developments today:   ... Stopek, PhD ... ... Veteran medical device executive ...
Breaking Medicine Technology: