Navigation Links
Genetic Trait May Predict Cocaine Sensitivity
Date:12/28/2010

TUESDAY, Dec. 28 (HealthDay News) -- A new study suggests that many white people carry a genetic trait that boosts the risk they'll develop an extreme and possibly deadly cocaine habit.

The trait appears to triple the odds of becoming susceptible to severe cocaine abuse that leads to death from an overdose, compared to non-carriers.

Researchers found signs of the genetic variation in more than 40 percent of brain samples taken from whites who abused cocaine. It was in just 19 percent of whites who didn't take drugs.

Overall, the genetic variant showed up in one in five samples from whites in the control group (and one in two to three samples in the cocaine overdose group), compared to one in eight African Americans, in whom the variant is less common.

The variations affect a neurotransmitter called dopamine that plays a role in helping the brain to feel euphoria when people take cocaine.

"We now have both good biological rationale and clinical association showing that this has an impact on the way cocaine abuse might progress or might be initiated," said study senior author Wolfgang Sadee, professor of pharmacology and director of the Program in Pharmacogenomics at Ohio State University, in a university statement.

"We have found a frequent variant in one of the key candidate genes that can affect cocaine abuse, but more importantly, it also opens the avenue to explore how this variant affects response to therapies for a variety of psychiatric disorders that involve dopamine."

More research is needed before the gene variants could be considered a marker for cocaine sensitivity, the researchers said.

The study is published online in the journal Neuropsychopharmacology.

More information

Learn more about cocaine from the U.S. National Library of Medicine.

-- Randy Dotinga

SOURCE: Ohio State University, news release, December 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Parents favor genetic testing for melanoma in their children
2. Genetic trait could triple odds of whites susceptibility to heavy cocaine abuse
3. MRI scans reveal brain changes in people at genetic risk for Alzheimers
4. deCODE discovers genetic markers that improve the power of PSA testing for detecting prostate cancer
5. Scientists Spot Genetic Areas Key to Embryonic Development
6. Genetic Research Sheds Light on Adrenal Gland Tumor Risk
7. Rare Genetic Syndrome May Increase Colon Cancer Risk
8. Chinese Study Suggests New Way to Test for Genetic Diseases
9. New discovery prevents symptoms of rare genetic disorder
10. Genetic mutations associated with increased PSA and prostate cancer
11. Novel genetic mutation that causes the most common form of eye cancer discovered
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genetic Trait May Predict Cocaine Sensitivity
(Date:8/22/2017)... ... August 22, 2017 , ... “To Walk Away”: ... a B17 bomber named Edward Koontz. “To Walk Away” is the creation of published ... has published over two hundred manuscripts in chemistry and religion, as well as four ...
(Date:8/22/2017)... ... August 22, 2017 , ... “Covert Awakening”: Walid’s ... of published author, Julianne Hale, a consultant for the Intelligence Community. For ... focusing on the Near East region. Julianne has written hundreds of reports ...
(Date:8/22/2017)... ... August 22, 2017 , ... TopConsumerReviews.com recently gave a best-in-class 5-star rating to ... As the stress of modern life continually makes more demands on time and energy, ... stimulants can trap people in vicious high/low cycles and can also cause long term ...
(Date:8/21/2017)... ... August 22, 2017 , ... PracticeMatch, a company that provides online resources ... physicians and advanced practitioners like nurse practitioners and physician assistants , ... November of this year. The online career fairs will allow job seekers to connect ...
(Date:8/21/2017)... ... August 21, 2017 , ... ... of two plastic surgery fellows for academic year 2017-2018, Christina M. Busuito, M.D. ... have successfully completed residency in Plastic and Reconstructive Surgery. The candidate will ...
Breaking Medicine News(10 mins):
(Date:8/2/2017)... 2, 2017  Life Flight Network and PeaceHealth Oregon Network ... patient care and operational efficiency for patients at hospitals in ... Cottage Grove , and Florence, ... and Life Flight Network work collaboratively to move patients who ... when a time sensitive emergency exists. ...
(Date:7/31/2017)... Pharmacy, Inc. (NYSE: DPLO), has been named one of the ... Crain,s Detroit Business . The annual Crain,s Fast ... growth. This year,s edition measures growth from 2013 to 2016. ... list, visit crainsdetroit.com/awards/fast_50/2017 .  "Being named ... Phil Hagerman , CEO and chairman of Diplomat. "We,ve made ...
(Date:7/28/2017)... Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), today ... June 30, 2017, and updated its financial outlook for ... For the fiscal third quarter, Hill-Rom reported earnings of ... share in the prior-year period. These results reflect after-tax ... share primarily related to the non-cash write-down of assets ...
Breaking Medicine Technology: