Navigation Links
Genetic Test May Someday Help Spot Breast Cancer
Date:12/9/2009

Positioning of genes could aid in detecting whether cells are cancerous, experts say,,

WEDNESDAY, Dec. 9 (HealthDay News) -- A new method of testing for breast tumors might one day all but eliminate false positives and false negatives from breast cancer diagnosis, new research suggests.

Within the cell nucleus, chromosomes and individual genes occupy specific locations relative to one another. That organization can change for many reasons, but one of them is cancer.

Researchers from the U.S. National Cancer Institute have honed in on several genes that have a different physical position inside the nucleus in invasive breast cancer cells than in normal breast tissue cells. A change in the position of one gene in particular, HES5, predicted invasive breast cancer nearly all of the time, they found.

The discovery suggests that looking at three-dimensional properties of the cell could one day be used as a new method of diagnosing breast cancer.

"Our hope is that our method would be useful as an early marker," said Tom Misteli, a cell biologist at the National Cancer Institute and the study's lead author. "We know that the position of the gene changes before the activity changes. That is a very, very early event in the tumor formation."

The study was published online Dec. 7 in the Journal of Cell Biology.

Typically, breast tumors are detected by a mammogram, which is basically an X-ray of the breast, or when a woman or her doctor feels a lump. To determine if the mass is cancerous or benign, a doctor would order a biopsy, which involves the removal of a small tissue sample that is then analyzed by a pathologist.

A pathologist looks at such factors as the shape and arrangement of cells to determine if a sample is cancerous. Some cancers are relatively easy to discern, said Dr. Victor Vogel, a breast cancer expert and the American Cancer Society's national vice president for research. But a few cases are judgment calls that even the most experienced pathologist isn't sure about, he said.

"It's just not black and white all the time," Vogel said.

Pathologists can have particular difficulty discerning the difference between non-cancerous hyperplasia, or an excess of cells, and ductal carcinoma in situ, a non-invasive and highly treatable form of breast cancer. At times it can be also difficult to tell the difference between ductal carcinoma in situ and invasive ductal carcinoma, a more aggressive and life threatening form of cancer.

"That's why this paper is so important," Vogel said. "What every pathologist and every patient wants is more diagnostic certainty."

Using 11 normal human breast tissue samples and 14 invasive cancer tissue samples, the researchers identified eight genes that were frequently repositioned in cancer specimens. They found that the repositioning of the gene HES5 indicated breast cancer in nearly all samples.

Previous research had implicated HES5 with cancer, according to background information in the study. In the new study, the researchers also found that changes in the location of several other combinations of two or three genes also indicated cancer with high accuracy.

"If validated in a larger number of samples, we envision that this approach may be a useful first molecular indicator of cancer after an abnormal mammogram," Misteli said. "Our method of cancer diagnosis is not limited to breast cancer and may be applied to any cancer type in which repositioned genes can be identified."

The next step, he said, is to replicate the findings using more tissue samples. "We think this method will be used in combination with conventional methods [such as mammogram and biopsy] but will make detection a lot stronger."

More information

The U.S. National Cancer Institute has more on breast cancer.



SOURCES: Tom Misteli, Ph.D., cell biologist and senior investigator, U.S. National Cancer Institute, Bethesda, Md.; Victor Vogel, M.D., national vice president, research, American Cancer Society, Atlanta; Dec. 7, 2009, Journal of Cell Biology, online


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. New License Agreement with University of Colorado Gives Viral Genetics, Inc., Right to Develop Cancer Therapies
2. Genetic variations indicate risk of recurrence, secondary cancer among head and neck cancer patients
3. Interleukin Genetics Receives Approval To Sell its PST(R) Periodontal Disease Genetic Test in New York
4. Genetic studies reveal new causes of severe obesity in childhood
5. Advances in Genetic Understanding and Treatment Protocols Lead to Significant Progress in Leukemia and Myeloproliferative Disorders
6. Wistar-led research team discovers genetic pattern that indicates early-stage lung cancer
7. Family Health History and Genetics Privacy is the Newest Addition to the ACMG Genetics & Your Health Video Series
8. Genetic Variant Slows AIDS Progression
9. Genetic changes shown to be important indicators for disease progression in cervical cancer patients
10. Cleveland Clinic Cancer Geneticist Charis Eng, M.D., Ph.D., Named To Federal Advisory Committee
11. Research Findings Key for Understanding, Interpreting Genetic Testing for Long QT Syndrome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... The ... to promote standards of excellence for the field of eating disorders, announces the ... – 25, 2018 in Orlando, Florida at the Omni Resort at ChampionsGate. ...
(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term insurance that ... insurance companies have a waiver for care if the client has a cognitive impairment ... family pays for care, is often waived, so the benefits from their insurance start ...
(Date:10/13/2017)... ... 13, 2017 , ... Talented host, actor Rob Lowe, is ... a new episode of "Success Files," which is an award-winning educational program broadcasted ... each subject in-depth with passion and integrity. , Sciatica occurs when the sciatic ...
(Date:10/12/2017)... CA (PRWEB) , ... October 12, 2017 , ... ... Cheng, are now treating sleep apnea using cutting-edge Oventus O2Vent technology. ... a serious sleep disorder characterized by frequent cessation in breathing. Oral appliances can ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, a ... health care, have expanded their existing home health joint venture through an agreement, ... been operating a joint venture home health company with Asante, delivering clinically integrated ...
Breaking Medicine News(10 mins):
(Date:10/7/2017)... IRVING, Texas , Oct. 6, 2017   ... industry with more than $100 billion in purchasing power, ... industry news and information. The Newsroom is ... chain and industry trends, infographics, expert bios, news releases, ... Besides having access to a wealth of resources at ...
(Date:10/2/2017)... -- Diplomat Pharmacy, Inc. (NYSE: DPLO ) ... , and named its founder as Diplomat,s chief information ... Tennessee , will operate under Diplomat subsidiary Envoy ... for health care partners to include IT outsourcing, consulting, ... "In an interoperable world, technology delivers comprehensive insight and ...
(Date:9/28/2017)... -- Hill-Rom Holdings, Inc. (NYSE: HRC), will host its ... on Friday, November 3, 2017, beginning at 7:00 a.m. ... 8:30 a.m. (CDT) / 9:30 a.m. (EDT). ... and guidance for 2018, Hill-Rom executives will also highlight ... and long-range financial outlook through 2020. ...
Breaking Medicine Technology: