Navigation Links
Genetic Research Sheds Light on Chronic Pain
Date:5/6/2010

Mouse study may lead to new drugs to help people who don't respond to existing treatments

THURSDAY, May 6 (HealthDay News) -- Chronic pain, which often occurs without an apparent cause, may be the result of accidental reprogramming of more than 2,000 genes in the peripheral nervous system, new research suggests.

The finding may someday lead to new drugs that treat pain by correcting the activity of specific genes, a method called transcription therapy, the researchers said.

In the study, published online in the journal Genome Research, Mayo Clinic researchers focused on dorsal root ganglion neurons of the peripheral nervous system in rodents. These nerve cells are suspected to be involved in pain.

The researchers studied hundreds of millions of messenger RNA (mRNA) molecules -- the messengers of gene activity. The team identified more than 10,000 new exons (sections of the genome involved in creating proteins) and about 400 candidate genes implicated in the pain response.

The new approach "may be an efficient new approach to a wide array of problems in neuroscience research," Dr. Andreas Beutler, Mayo Clinic oncologist and corresponding author on the study, added in a news release.

Chronic pain, which affects 50 million Americans, often fails to respond to available treatments, and costs the United States about $100 billion in health costs, lost time at work and other economic effects annually, according to the U.S. National Institutes of Health.

More information

The American Academy of Family Physicians has more about chronic pain.



-- Robert Preidt



SOURCE: Mayo Clinic, news release, May 6, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Page: 1

Related medicine news :

1. High doses of antioxidant supplements induce stem cell genetic abnormalities
2. New research about human genetic diseases and human development
3. Genetics, Psychology May Trigger ADHD
4. Plant pathogen genetically tailors attacks to each part of host, say Stanford researchers
5. Study finds changes in fetal epigenetics throughout pregnancy
6. Lab that probes genetic clues to disease is poised for major expansion
7. Single Genetic Factor Key to Cardiovascular System
8. Genetic Engineering Raises Hope for Lyme Disease Vaccine
9. Parkinsons Linked to Genetic Mutation
10. Newer Genetic Info Adds Little to Predicting Breast Cancer
11. Newer Genetic Test for Autism More Effective
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2014)... In today’s world, a good night’s sleep has become ... apnea (a medical problem where the airway collapses during sleep ... the rest they need to face their daily challenges. ... million people in the United States alone have sleep apnea. ... of those treated, many cannot tolerate their prescribed medical device ...
(Date:8/30/2014)... (PRWEB) August 30, 2014 "My niece ... knowing that, at any moment, her fever might get ... to keep me well aware of how she was ... the TEMP ALARM to continuously monitor a child's temperature. ... a fever. This ensures that prompt medical care can ...
(Date:8/30/2014)... 30 August 2014: Transvenous lead extraction (TLE) is clinically ... data from the European Lead Extraction ConTRolled (ELECTRa) registry ... 2014 by Dr Maria Grazia Bongiorni, chair of the ... of cardiac implantable electronic devices (CIED) implant procedures has ... number of complications has increased and leads are often ...
(Date:8/30/2014)... The new review published by Daily Gossip ... Karen Brimeyer, who wanted to make her guide accessible to ... is now easy to find in the form of an ... the author of the new method shares all her tips ... writes in its review that the leaky gut syndrome can ...
(Date:8/30/2014)... Jake W., 18, is completing his high ... Back2Basics Outdoor Adventures transition program known as Beyond the ... I can actually start on a real career path,” said ... done.” , He has six months of sobriety under his ... choose to continue on to the Beyond the Basics transition ...
Breaking Medicine News(10 mins):Health News:Snoring: Bad for Relationships, Bad for Health 2Health News:Snoring: Bad for Relationships, Bad for Health 3Health News:Transvenous lead extraction clinically successful in 98 percent of cases 2Health News:Transvenous lead extraction clinically successful in 98 percent of cases 3Health News:Leaky Gut Cure Review Reveals Unique Method to Stop Chronic Symptoms 2
... In a unique research effort, kin cancer researchers from all ... umbrella to help the world understand what exactly their risk ... the international Genomel consortium based in Leeds, England has been ... will lead the teams from around the world. All these ...
... Institute of Neurological Disease have found that the protein ... //that acts by inactivating the conversion of glucose into ... released from apoE. ,The apoE protein is ... not providing the glucose present in the brain to ...
... population runs a risk that is four times higher ... to the Australian Institute of Health and Welfare (AIHW).// ... attack. Between 2001 and 2003, almost 21,000 people aged ... diabetes. ,During the period under review ...
... religion plays in a patient's life positively affect physician bedside ... and no, for male medicos.// ,According to a ... Medical Journal, patients want their physicians to be aware of ... issues with them, especially if they are preparing for death. ...
... from an acute shortage of nurses, with some schools having ... across the country in schools on a fulltime basis.// This ... federal guidelines call for a nurse for every 750 students. ... when compared to other parts of the country. Because of ...
... his new book 'The Failure of Democratic Nation Building: Ideology ... that Democracy should not or cannot be forcibly thrusted on ... an intrinsic need for hierarchical and authoritarian social and political ... hand requires unique conditions before it is accepted by the ...
Cached Medicine News:Health News:Religious sensitivity of medicos gender-dependent 2Health News:School Children Put To Risk Due To Shortage Of Nurses 2
(Date:8/29/2014)... VANCOUVER, British Columbia and MENLO ... -- DelMar Pharmaceuticals, Inc. (OTCQB: DMPI) ("DelMar" ... 2014 fiscal year-end financial statements.  The Company recently changed ... to facilitate an application to list its common stock ... possible. DelMar,s financial statements as filed with ...
(Date:8/29/2014)... , Aug. 29, 2014 ... PHG AEX: PHIA) ... European Society of Cardiology (ESC) Congress ... highlighting the full range of its cardiology solutions serving clinicians ... from prevention and diagnosis, to ...
(Date:8/28/2014)... , Aug. 28, 2014 Reportlinker.com ... is available in its catalogue: ... http://www.reportlinker.com/p02332847/Needle-Free-Delivery-Technology-and-Market-Forecast-2014-2024.html ... discover technological and commercial prospects What does ... market? Visiongain,s brand new report shows you ...
Breaking Medicine Technology:DelMar Pharmaceuticals Fiscal 2014 Year End Results and Summary of Recent Developments 2DelMar Pharmaceuticals Fiscal 2014 Year End Results and Summary of Recent Developments 3DelMar Pharmaceuticals Fiscal 2014 Year End Results and Summary of Recent Developments 4DelMar Pharmaceuticals Fiscal 2014 Year End Results and Summary of Recent Developments 5Philips Spotlights New Cardiology Solutions and Unveils Ultrasound Technology at European Society of Cardiology Congress 2014 2Philips Spotlights New Cardiology Solutions and Unveils Ultrasound Technology at European Society of Cardiology Congress 2014 3Philips Spotlights New Cardiology Solutions and Unveils Ultrasound Technology at European Society of Cardiology Congress 2014 4Philips Spotlights New Cardiology Solutions and Unveils Ultrasound Technology at European Society of Cardiology Congress 2014 5Needle-Free Delivery: Technology and Market Forecast 2014-2024 2Needle-Free Delivery: Technology and Market Forecast 2014-2024 3Needle-Free Delivery: Technology and Market Forecast 2014-2024 4Needle-Free Delivery: Technology and Market Forecast 2014-2024 5Needle-Free Delivery: Technology and Market Forecast 2014-2024 6Needle-Free Delivery: Technology and Market Forecast 2014-2024 7Needle-Free Delivery: Technology and Market Forecast 2014-2024 8Needle-Free Delivery: Technology and Market Forecast 2014-2024 9Needle-Free Delivery: Technology and Market Forecast 2014-2024 10Needle-Free Delivery: Technology and Market Forecast 2014-2024 11Needle-Free Delivery: Technology and Market Forecast 2014-2024 12Needle-Free Delivery: Technology and Market Forecast 2014-2024 13Needle-Free Delivery: Technology and Market Forecast 2014-2024 14Needle-Free Delivery: Technology and Market Forecast 2014-2024 15Needle-Free Delivery: Technology and Market Forecast 2014-2024 16Needle-Free Delivery: Technology and Market Forecast 2014-2024 17Needle-Free Delivery: Technology and Market Forecast 2014-2024 18
... , NEW YORK, Nov. 25 Reportlinker.com ... in its catalogue: , Intranasal Drug Delivery - ... , The US intranasal drug delivery market is witnessing ... conventional local therapeutic drugs to the delivery of systemic ...
... , BETHESDA, Md., Nov. 24 ... independent American provider of Western,healthcare products and services in the People,s ... Annual Piper Jaffray,"Unplugged" Health Care Conference, to be held December 1 ... Management is currently scheduled to present at 11:30 am ...
Cached Medicine Technology:Reportlinker Adds Intranasal Drug Delivery - US Market Trends & Analysis 2Reportlinker Adds Intranasal Drug Delivery - US Market Trends & Analysis 3Reportlinker Adds Intranasal Drug Delivery - US Market Trends & Analysis 4Reportlinker Adds Intranasal Drug Delivery - US Market Trends & Analysis 5Chindex International to Present at Piper Jaffray Health Care Conference 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: