Navigation Links
Genetic Research Sheds Light on Chronic Pain
Date:5/6/2010

Mouse study may lead to new drugs to help people who don't respond to existing treatments

THURSDAY, May 6 (HealthDay News) -- Chronic pain, which often occurs without an apparent cause, may be the result of accidental reprogramming of more than 2,000 genes in the peripheral nervous system, new research suggests.

The finding may someday lead to new drugs that treat pain by correcting the activity of specific genes, a method called transcription therapy, the researchers said.

In the study, published online in the journal Genome Research, Mayo Clinic researchers focused on dorsal root ganglion neurons of the peripheral nervous system in rodents. These nerve cells are suspected to be involved in pain.

The researchers studied hundreds of millions of messenger RNA (mRNA) molecules -- the messengers of gene activity. The team identified more than 10,000 new exons (sections of the genome involved in creating proteins) and about 400 candidate genes implicated in the pain response.

The new approach "may be an efficient new approach to a wide array of problems in neuroscience research," Dr. Andreas Beutler, Mayo Clinic oncologist and corresponding author on the study, added in a news release.

Chronic pain, which affects 50 million Americans, often fails to respond to available treatments, and costs the United States about $100 billion in health costs, lost time at work and other economic effects annually, according to the U.S. National Institutes of Health.

More information

The American Academy of Family Physicians has more about chronic pain.



-- Robert Preidt



SOURCE: Mayo Clinic, news release, May 6, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Page: 1

Related medicine news :

1. High doses of antioxidant supplements induce stem cell genetic abnormalities
2. New research about human genetic diseases and human development
3. Genetics, Psychology May Trigger ADHD
4. Plant pathogen genetically tailors attacks to each part of host, say Stanford researchers
5. Study finds changes in fetal epigenetics throughout pregnancy
6. Lab that probes genetic clues to disease is poised for major expansion
7. Single Genetic Factor Key to Cardiovascular System
8. Genetic Engineering Raises Hope for Lyme Disease Vaccine
9. Parkinsons Linked to Genetic Mutation
10. Newer Genetic Info Adds Little to Predicting Breast Cancer
11. Newer Genetic Test for Autism More Effective
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... ... Lori R. Somekh, founder of the Law Office of Somekh & Associates ... special needs planning attorneys. “Membership in ElderCounsel helps our office remain up to date ... elder law attorneys nationwide,” said Somekh. , ElderCounsel was founded by ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Ellevate Network, the ... business to advocate for action towards gender equality at their inaugural Summit in New ... the globe, and reached a social audience of over 3 million. To watch the ...
(Date:10/13/2017)... Fairfax, VA (PRWEB) , ... October 13, 2017 ... ... provider of DevOps and Agile Software Development, has been awarded a contract by ... (EATS) Blanket Purchase Agreement (BPA) aims to accelerate the enterprise use of Agile ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and San Francisco ... using cutting-edge Oventus O2Vent technology. As many as 18 million Americans are estimated ... in breathing. Oral appliances can offer significant relief to about 75 percent of ...
(Date:10/12/2017)... Bethesda, MD (PRWEB) , ... October 12, 2017 , ... ... Award of Excellence to Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s ... 4 – 8. , In honor of Morris F. Collen, a pioneer in the ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... Oct. 2, 2017 The Rebound mobile app is ... to reverse the tide of prescription drug addiction. The app ... medicine intake and stepping down their dosage in a safe, ... in December 2017; the first 100,000 people to sign up ... http://www.rebound-solution.com/ ...
(Date:9/28/2017)... Cohen Veterans Bioscience and Early Signal Foundation announce a ... sensors for real-time monitoring of patients with trauma-related and ... focused on disruptive health solutions for rare disorders and ... record and integrate behavioral, cognitive, physiological and contextual data. ... ...
(Date:9/27/2017)... NEW YORK , Sept. 27, 2017  DarioHealth Corp. ... big data solutions, today announced that its MyDario product is expected to ... TV listings for when The Dr. Oz Show airs in your area: ... The nine-time Emmy award-winning, ... ...
Breaking Medicine Technology: