Navigation Links
Genetic Markers May Predict Lung Cancer Recurrence

DNA evidence in lymph nodes could alter treatment approach, study suggests

WEDNESDAY, March 12 (HealthDay News) -- Certain genetic alterations in tumors and tissue from patients with early-stage lung cancer may identify those at greatest risk for cancer recurrence, say researchers at the Johns Hopkins Kimmel Cancer Center.

They said the finding could alter the treatment approach for lung cancers, which recur within five years in 30 percent to 40 percent of patients.

"This is DNA forensics for cancer. While there may be no trace of cancer that we can spot after surgery with a microscope, the DNA evidence from these tumors may have been left at the scene, especially in lymph nodes," Dr. Malcolm Brock, an associate professor of surgery at Johns Hopkins, said in a prepared statement.

He and his colleagues analyzed more than 700 surgical samples from 167 patients with early-stage, non-small cell lung cancer (51 whose cancer recurred within 40 months and 116 whose cancer did not recur) to identify specific methylation patterns associated with lung cancer.

In methylation, chemicals known as methyl groups attach to the DNA ladder structure of a gene, which can cause problems that lead to the development or recurrence of cancer. Of seven genes known to be linked to lung cancer, four of them -- p16, H-cadherin, APC and RASSF1A -- showed the highest amounts of methylation in patients with recurrent lung cancer.

Many of the genes showed a twofold difference in methyl marks between recurrent cancer and non-recurrent cancer, the study found.

"The DNA evidence we see for many of the recurring cases suggests it may be wise if our work is confirmed to reclassify such cancers as advanced disease instead of early-stage," Brock said.

He and his team also found lung cancer returned more quickly than average among 11 patients with higher than normal methylation in two genes -- p16 and H-cadherin -- located in both tumor tissue and a lymph node distant from the original tumor site. In eight of the 11 patients, lung cancer recurred within a year, and recurred in the remaining three patients within 30 months.

The study was published in the March 13 issue of the New England Journal of Medicine.

More information

The U.S. National Cancer Institute has more about lung cancer.

-- Robert Preidt

SOURCE: Johns Hopkins Medicine, news release, March 12, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Genetic analysis reveals range of Rett syndrome
2. Genetic research unveils common origins for distinct clinical diagnoses
3. New stem cell technique improves genetic alteration
4. Einstein researchers genetically engineer immune cells into potent weapons for battling HIV
5. Genetic Test Predicts Response to Warfarin
6. New revelations in epigenetic control shed light on breast cancer
7. Researchers identify new genetic marker for breast cancer
8. Anti-Aging/Genetic Health Leader Suracell, Inc. Expands Internationally
9. Adult stem cell changes underlie rare genetic disease associated with accelerated aging
10. Genetic Factors for Smoking Boost Chronic Bronchitis Risk
11. Genetic factors in smoking also increase risk of chronic bronchitis
Post Your Comments:
Related Image:
Genetic Markers May Predict Lung Cancer Recurrence 
(Date:6/26/2016)... , ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified personal ... personalized through a fitness app. The fitness app plans to fix the two major problems ... offer a one size fits all type program , They don’t eliminate all ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes ... important health care topics including advance care planning, healthcare costs and patient and ...
(Date:6/25/2016)... ... 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due to a ... new, often overlooked aspect of head lice: the parasite’s ability to live away from a ... occurrence, but a necessary one in the event that lice have simply gotten out of ...
(Date:6/25/2016)... ... 2016 , ... First Choice Emergency Room , the largest network of ... Medical Director of its new Mesquite-Samuell Farm facility. , “We are pleased to ... said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin ... injury. Recently, he has implemented orthobiologic procedures as a method for treating his ... of the first doctors to perform the treatment. Orthobiologics are substances that orthopaedic ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016 Capricor ... ), a biotechnology company focused on the discovery, ... that patient enrollment in its ongoing randomized HOPE-Duchenne ... exceeded 50% of its 24-patient target. Capricor expects ... third quarter of 2016, and to report top ...
(Date:6/23/2016)... NORTHBROOK, Ill. and BOGOTA, Colombia , June 23, 2016  Astellas today announced the ... joins Astellas Farma Brasil as the company,s second affiliate in Latin America . ... ... appointed General Manager of Astellas Farma Colombia ... ...
(Date:6/23/2016)... , June 23, 2016  Experian Health, ... and transforming the patient payment and care ... innovative new products and services that will ... revenue cycle offerings. These award-winning solutions will ... workflows, remain compliant in an ever-changing environment ...
Breaking Medicine Technology: