Navigation Links
Genetic Markers May Predict Lung Cancer Recurrence

DNA evidence in lymph nodes could alter treatment approach, study suggests

WEDNESDAY, March 12 (HealthDay News) -- Certain genetic alterations in tumors and tissue from patients with early-stage lung cancer may identify those at greatest risk for cancer recurrence, say researchers at the Johns Hopkins Kimmel Cancer Center.

They said the finding could alter the treatment approach for lung cancers, which recur within five years in 30 percent to 40 percent of patients.

"This is DNA forensics for cancer. While there may be no trace of cancer that we can spot after surgery with a microscope, the DNA evidence from these tumors may have been left at the scene, especially in lymph nodes," Dr. Malcolm Brock, an associate professor of surgery at Johns Hopkins, said in a prepared statement.

He and his colleagues analyzed more than 700 surgical samples from 167 patients with early-stage, non-small cell lung cancer (51 whose cancer recurred within 40 months and 116 whose cancer did not recur) to identify specific methylation patterns associated with lung cancer.

In methylation, chemicals known as methyl groups attach to the DNA ladder structure of a gene, which can cause problems that lead to the development or recurrence of cancer. Of seven genes known to be linked to lung cancer, four of them -- p16, H-cadherin, APC and RASSF1A -- showed the highest amounts of methylation in patients with recurrent lung cancer.

Many of the genes showed a twofold difference in methyl marks between recurrent cancer and non-recurrent cancer, the study found.

"The DNA evidence we see for many of the recurring cases suggests it may be wise if our work is confirmed to reclassify such cancers as advanced disease instead of early-stage," Brock said.

He and his team also found lung cancer returned more quickly than average among 11 patients with higher than normal methylation in two genes -- p16 and H-cadherin -- located in both tumor tissue and a lymph node distant from the original tumor site. In eight of the 11 patients, lung cancer recurred within a year, and recurred in the remaining three patients within 30 months.

The study was published in the March 13 issue of the New England Journal of Medicine.

More information

The U.S. National Cancer Institute has more about lung cancer.

-- Robert Preidt

SOURCE: Johns Hopkins Medicine, news release, March 12, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Genetic analysis reveals range of Rett syndrome
2. Genetic research unveils common origins for distinct clinical diagnoses
3. New stem cell technique improves genetic alteration
4. Einstein researchers genetically engineer immune cells into potent weapons for battling HIV
5. Genetic Test Predicts Response to Warfarin
6. New revelations in epigenetic control shed light on breast cancer
7. Researchers identify new genetic marker for breast cancer
8. Anti-Aging/Genetic Health Leader Suracell, Inc. Expands Internationally
9. Adult stem cell changes underlie rare genetic disease associated with accelerated aging
10. Genetic Factors for Smoking Boost Chronic Bronchitis Risk
11. Genetic factors in smoking also increase risk of chronic bronchitis
Post Your Comments:
Related Image:
Genetic Markers May Predict Lung Cancer Recurrence 
(Date:12/1/2015)... MD (PRWEB) , ... December 01, 2015 , ... ... salmon identification tests to continue the expansion of the company’s growing product line ... – for Chinook (Oncorhynchus tshawytscha) and Sockeye (Oncorhynchus nerka) – allow InstantLabs to ...
(Date:12/1/2015)... , ... December 01, 2015 , ... ... medical images have been lifted as IMAGE Information Systems launches MED-TAB™ -- the ... North America Annual Meeting from November 29 to December 4, 2015. , ...
(Date:12/1/2015)... Libertyville, IL (PRWEB) , ... December 01, 2015 ... ... catheters, keeping their independence is everything. That is why Hollister Incorporated has launched ... excited to offer this next product in the VaPro touch free catheter portfolio,” ...
(Date:12/1/2015)... ... ... McLean, VA., December 1, 2015 - Octo Consulting Group, ... development contract to support the National Geospatial-Intelligence Agency's (NGA) IT Services Directorate. ... as well as operations and sustainment support to the NGA’s Agile Web Presence ...
(Date:12/1/2015)... ... December 01, 2015 , ... XTC Semifinals 2016 - ... to head to Las Vegas for CES 2016, the world’s largest Consumer Electronic Show, ... Technology Association Gary Shapiro, Founding Partner of Pacific Investments Veronica Serra, and venture capitalist ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... Dec. 1, 2015 As enforcement of the ... Security Act (DSCSA) approaches, InfiniTrak announced ... pharmacies comply with looming FDA regulations. ... entering endorsement agreements with State Pharmacy Associations, an ... organization (PSAO) to exclusively provide the InfiniTrak track-and-trace ...
(Date:12/1/2015)... CLEVELAND , Dec. 1, 2015   ... innovation firm, today announced the publication of a ... Entering the Direct-to-Consumer Medical Market". The whitepaper gives ... roadmap for successfully penetrating this lucrative segment. ... purchase healthcare products to manage their own health, ...
(Date:12/1/2015)... 2015 --> --> ... Market by Type of Drug (Monoclonal Antibodies, Interferon-Alpha, Interleukins, Vaccines, ... Pipeline Analysis - Global Forecast to 2020", published by MarketsandMarkets, ... 73,529.2 Million by 2020 from USD 40,281.6 Million in 2015, ... Browse 37 market data T ...
Breaking Medicine Technology: