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Genetic Links to Rare Liver Disease Found
Date:6/10/2009

hin the interleukin-12 immunoregulatory-signaling pathway, offering a novel new insight into the pathogenesis of primary biliary cirrhosis, with the attendant opportunity to better understand the key mechanisms in the evolution and progression of this disease, and to ultimately develop new therapies based on this understanding," he said.

More information

For more information on primary biliary cirrhosis, visit the U.S. National Institute of Diabetes and Digestive and Kidney Diseases.



SOURCES: Katherine Siminovitch, M.D., senior investigator, Samuel Lunenfeld Research Institute of Mount Sinai Hospital, Toronto; Scott L. Friedman, M.D., Fishberg Professor of Medicine, and chief, division of liver diseases, Mount Sinai School of Medicine, New York City, and president, American Association for the Study of Liver Diseases; Nathan M. Bass, M.D., Ph.D., medical director, liver transplant service for adults, University of California, San Francisco; June 11, 2009, New England Journal of Medicine


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