Navigation Links
Genetic Discovery May Improve Hepatitis C Treatment
Date:8/17/2009

Finding will help predict patient response to therapy, researchers say

MONDAY, Aug. 17 (HealthDay News) -- The first biomarker that predicts a patient's response to hepatitis C treatments has been identified by U.S. researchers.

The new marker is a single letter change -- a C instead of a T -- in a segment of DNA near the IL28B gene, according to the Duke University Medical Center team. They found it by studying the DNA of 1,671 people taking part in a study of hepatitis C treatments.

Not only does this biomarker predict who is most likely to respond to treatment and who isn't, it may solve the long-standing question of why responses to hepatitis C treatments vary so widely among racial and ethnic groups.

"For geneticists, understanding response to treatment for hepatitis C infection has been almost like a Holy Grail," study senior author David Goldstein, director of the Center for Human Genome Variation at Duke's Institute for Genome Sciences & Policy, said in a university news release.

"The side effects of hepatitis treatment can be brutal, and about half the time, the treatment fails to eradicate the virus. This discovery enables us to give patients valuable information that will help them and their doctors decide what is best for them. This is what personalized medicine is all about," Goldstein said.

The study appeared online Aug. 16 in the journal Nature.

Hepatitis C, one of the most common infections in the world, affects about 170 million people. Treatment typically involves 48 weeks of interferon plus the antiviral drug ribavirin. Black patients are less likely to respond to treatment than white patients, while East Asian patients seem to have the best response.

More information

The U.S. Centers for Disease Control and Prevention has more about hepatitis C.



-- Robert Preidt



SOURCE: Duke University Medical Center, news release, Aug. 16, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New Genetic Link Suspected for Muscular Dystrophy
2. Carnegie Mellon develops innovative method to detect genetic causes of complex diseases
3. Addario Lung Cancer Medical Institute Announces Diagnostic Screening and Clinical Research Collaborations With Response Genetics, Inc.
4. March of Dimes Celebrates 50th Anniversary of Genetics Short Course
5. Comprehensive Look at Rare Leukemia Finds Relatively Few Genetic Changes Launch Disease
6. Genetic testing may be valuable in treating colorectal cancer
7. NIH Plan Charts Course to Better Treatments and Cure for Most Common Known Genetic Cause of Autism: Fragile X
8. Studies Show Genetic Activity of Antioxidants
9. Genetic Variation Associated With Survival Advantage in African Americans With HIV
10. Study Shows a Link Between Schizophrenia & Genetic Mutations
11. Teen Behaviors Stem From Genetics, Environment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genetic Discovery May Improve Hepatitis C Treatment
(Date:2/11/2016)... ... February 11, 2016 , ... Florida Hospital presents Heart ... on the St. Louis Blues at the Amalie Arena. The puck drops at 6:00pm, ... heart exhibit, the MEGA Heart, prior to the game. The MEGA Heart will be ...
(Date:2/11/2016)... ... February 11, 2016 , ... ... ranked among the top five firms in the “2015/2016 Best in KLAS: Software ... and Staffing. KLAS is a research and insights firm on a global mission ...
(Date:2/11/2016)... ... February 11, 2016 , ... In a ... Dallas plastic surgeon , Dr. Rod J. Rohrich, and colleagues, examine and underscore ... outlines recommendations for rhinoplasty surgeons when addressing this vital area. , The upper ...
(Date:2/11/2016)... ... February 11, 2016 , ... "What holds you ... Ray Clarke poses a question as a challenge for his readers to examine ... in the Being" (published by Partridge Singapore), Clarke explores the subject with more ...
(Date:2/11/2016)... , ... February 11, 2016 , ... Colorado spine surgeon, ... one of 334 spine surgeons to know in 2016 . The list consists ... field of spine surgery. , Dr. Corenman understands the importance of clinical excellence; ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... and PORTLAND, Ore. , Feb. ... optimization company, is pleased to announce the acquisition of ... community and rural access hospitals. Along with providing traditional ... 340B consulting services to assist clients in navigating the ... Love , CEO of Wellpartner. --> James ...
(Date:2/11/2016)... DUBLIN, February 11, 2016 Transformational M&A ... with Baxalta   --> Transformational M&A achieved through ...   --> Transformational M&A achieved through NPS ... Positioned for future growth with most robust pipeline ... Positioned for future growth with most robust pipeline in ...
(Date:2/11/2016)... , February 11, 2016 ... release of a new research report, titled "Sports Medicine Devices ... Forecast, 2013 - 2019". According to the report, the global ... 4.40% CAGR from 2013 to 2019, growing from a value ... --> --> The global ...
Breaking Medicine Technology: