Navigation Links
Genetic Data May Not Boost Heart Disease Predictions
Date:1/19/2009

Traditional risk factors are just as reliable, researchers say,,,,

MONDAY, Jan. 19 (HealthDay News) -- Although a particular genetic variation is associated with an increased risk for heart disease, knowing about it does not help doctors predict who is likely to get heart disease any more than using traditional risk factors, a new study finds.

There has been continuing excitement in recent years about the power of gene variations in predicting the risk for disease. However, in this case, knowing a variation increases the risk of cardiovascular trouble did not add more valuable information than could be gleaned from other risk factors, such as high blood pressure, high cholesterol and family history.

"Gene patterns are associated with an increased risk of heart disease, and the higher risk patterns are common," said lead researcher Nina P. Paynter, an instructor in medicine at Brigham and Women's Hospital in Boston and Harvard Medical School.

"However, it was not known if knowledge of a person's pattern, when added to knowledge of traditional risk factors including family history of heart disease, would improve the ability to predict levels of future heart disease risk for that person and possibly help with treatment decisions," she said.

The report is published in the Jan. 20 issue of the Annals of Internal Medicine.

For the study, Paynter's team collected data on 22,129 women who participated in the Women's Genome Health Study. At the start of the study, the women were free from any major chronic diseases.

Over 10.2 years of follow-up, the researchers found that adding information about gene patterns at a specific section of the genome, namely chromosome 9p21.3, did not meaningfully improve the ability to predict heart disease, compared with the use of traditional risk factors.

"This study only included white women, so it is not known if the results are applicable to women of different backgrounds or to men," Paynter noted.

Dr. Harlan M. Krumholz, a professor of cardiology at Yale University School of Medicine, put it this way: "It's an important study that should give us pause that information about whether our DNA will trump what we know from established risk factors. The genetic work is important in efforts to find targets for future therapies, but addressing modifiable risk factors is where we need to direct our attention."

However, Dr. Byron Lee, an assistant professor of cardiology at the University of California, San Francisco, noted that "while in this study, DNA testing did not improve our ability to predict cardiovascular disease, which is based on traditional risk factors like smoking and hypertension, there are literally millions of other specific genetic tests to look at."

"I expect DNA testing to become a standard part of risk assessment in the near future," Lee said.

More information

For more information on heart disease, visit the American Heart Association .



SOURCES: Nina P. Paynter, Ph.D., instructor in medicine, Brigham and Women's Hospital, Harvard Medical School, Boston; Byron Lee, M.D., assistant professor, cardiology, University of California, San Francisco; Harlan M. Krumholz, M.D., professor of cardiology, Yale University School of Medicine, New Haven, Conn.; Jan. 20, 2009, Annals of Internal Medicine


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Genetic Data May Predict Colon Cancer Odds
2. FDA Issues Final Regulations for Genetically Engineered Animals
3. UT leads $2.5 million training program in pioneering area of genetic research
4. Identification of genetic markers for ulcerative colitis could lead to treatment
5. CellCyte Genetics Corporation: Seattle Times Erroneously Reports That CellCyte Closes
6. Beta Release of a New Genetics Website- ItRunsInMyFamily.com
7. New Genetic Analysis Might Boost Breast Cancer Care
8. Genetic Variants Tied to Obesity
9. Genetic Link Between Type 1 Diabetes, Celiac Disease Seen
10. Genetic Markers Identified for Alcohol Response in UCSF Gallo Study
11. PTSD Risk Rooted in Stress and Genetics
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genetic Data May Not Boost Heart Disease Predictions 
(Date:10/13/2017)... Milford, NJ (PRWEB) , ... October 13, 2017 , ... ... weekend at scenic Alexandria Park in Milford, NJ. This free event, sponsored by ... and physical activity. The fun run is geared towards children of all ages; ...
(Date:10/13/2017)... ... 2017 , ... Talented host, actor Rob Lowe, is introducing ... new episode of "Success Files," which is an award-winning educational program broadcasted on ... subject in-depth with passion and integrity. , Sciatica occurs when the sciatic nerve ...
(Date:10/13/2017)... ... , ... “The Journey: From the Mountains to the Mission Field”: the story ... the Philippines. “The Journey: From the Mountains to the Mission Field” is the creation ... has taught all ages and currently teaches a class of ladies at her church, ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... healthcare compliance program management, will showcase a range of technology and learning solutions ... Living (NCAL) Convention and Expo to be held October 14–18, 2017 at the ...
(Date:10/12/2017)... LA (PRWEB) , ... October 12, 2017 , ... Planet ... in the U.S., announced today its plans to open a flagship location in Covington, ... occupy the former Rooms To Go store next to Office Depot in the Holiday ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)...  NDS received FDA 510(k) clearance in May 2017 for its ... specifically designed for endoscopy environments. An innovative secondary monitor solution, ZeroWire ... to support the improvement of patient outcomes, procedural efficiency, and the ... ... ...
(Date:10/7/2017)...   Provista, a proven leader in the ... purchasing power, today announced a new resource area on ... is the online home for case studies, articles ... news releases, slideshows and events. ... resources at their fingertips, viewers can also watch short ...
(Date:10/4/2017)... Korea , Oct. 4, 2017  South Korean-based ... next-generation CPR training aide "cprCUBE" on Kickstarter. The device ... compression during cardiac arrests with better efficiency compared to ... also offers real-time feedback on efficacy of the compression ... crowdfunding campaign has a goal to raise $5,000. ...
Breaking Medicine Technology: