Navigation Links
Genetic Data May Not Boost Heart Disease Predictions
Date:1/19/2009

Traditional risk factors are just as reliable, researchers say,,,,

MONDAY, Jan. 19 (HealthDay News) -- Although a particular genetic variation is associated with an increased risk for heart disease, knowing about it does not help doctors predict who is likely to get heart disease any more than using traditional risk factors, a new study finds.

There has been continuing excitement in recent years about the power of gene variations in predicting the risk for disease. However, in this case, knowing a variation increases the risk of cardiovascular trouble did not add more valuable information than could be gleaned from other risk factors, such as high blood pressure, high cholesterol and family history.

"Gene patterns are associated with an increased risk of heart disease, and the higher risk patterns are common," said lead researcher Nina P. Paynter, an instructor in medicine at Brigham and Women's Hospital in Boston and Harvard Medical School.

"However, it was not known if knowledge of a person's pattern, when added to knowledge of traditional risk factors including family history of heart disease, would improve the ability to predict levels of future heart disease risk for that person and possibly help with treatment decisions," she said.

The report is published in the Jan. 20 issue of the Annals of Internal Medicine.

For the study, Paynter's team collected data on 22,129 women who participated in the Women's Genome Health Study. At the start of the study, the women were free from any major chronic diseases.

Over 10.2 years of follow-up, the researchers found that adding information about gene patterns at a specific section of the genome, namely chromosome 9p21.3, did not meaningfully improve the ability to predict heart disease, compared with the use of traditional risk factors.

"This study only included white women, so it is not known if the results are applicable to women of different backgrounds or to men," Paynter noted.

Dr. Harlan M. Krumholz, a professor of cardiology at Yale University School of Medicine, put it this way: "It's an important study that should give us pause that information about whether our DNA will trump what we know from established risk factors. The genetic work is important in efforts to find targets for future therapies, but addressing modifiable risk factors is where we need to direct our attention."

However, Dr. Byron Lee, an assistant professor of cardiology at the University of California, San Francisco, noted that "while in this study, DNA testing did not improve our ability to predict cardiovascular disease, which is based on traditional risk factors like smoking and hypertension, there are literally millions of other specific genetic tests to look at."

"I expect DNA testing to become a standard part of risk assessment in the near future," Lee said.

More information

For more information on heart disease, visit the American Heart Association .



SOURCES: Nina P. Paynter, Ph.D., instructor in medicine, Brigham and Women's Hospital, Harvard Medical School, Boston; Byron Lee, M.D., assistant professor, cardiology, University of California, San Francisco; Harlan M. Krumholz, M.D., professor of cardiology, Yale University School of Medicine, New Haven, Conn.; Jan. 20, 2009, Annals of Internal Medicine


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Genetic Data May Predict Colon Cancer Odds
2. FDA Issues Final Regulations for Genetically Engineered Animals
3. UT leads $2.5 million training program in pioneering area of genetic research
4. Identification of genetic markers for ulcerative colitis could lead to treatment
5. CellCyte Genetics Corporation: Seattle Times Erroneously Reports That CellCyte Closes
6. Beta Release of a New Genetics Website- ItRunsInMyFamily.com
7. New Genetic Analysis Might Boost Breast Cancer Care
8. Genetic Variants Tied to Obesity
9. Genetic Link Between Type 1 Diabetes, Celiac Disease Seen
10. Genetic Markers Identified for Alcohol Response in UCSF Gallo Study
11. PTSD Risk Rooted in Stress and Genetics
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genetic Data May Not Boost Heart Disease Predictions 
(Date:10/13/2017)... ... October 13, 2017 , ... ... communities in the greater Dallas, Miami, and Raleigh regions, is organizing an extended ... overcome a rare and deadly chromosome abnormality. , After struggling since birth with ...
(Date:10/13/2017)... , ... October 13, 2017 , ... ... the certification process to promote standards of excellence for the field of eating ... for March 22 – 25, 2018 in Orlando, Florida at the Omni Resort ...
(Date:10/13/2017)... SAN LUIS OBISPO, Calif. (PRWEB) , ... October 13, 2017 , ... ... with Alzheimer’s or dementia. However, many long-term care insurance companies have a waiver for ... mean is the 90-day elimination period, when the family pays for care, is often ...
(Date:10/13/2017)... ... 2017 , ... Talented host, actor Rob Lowe, is introducing ... new episode of "Success Files," which is an award-winning educational program broadcasted on ... subject in-depth with passion and integrity. , Sciatica occurs when the sciatic nerve ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent ... sleep apnea using cutting-edge Oventus O2Vent technology. As many as 18 million ... by frequent cessation in breathing. Oral appliances can offer significant relief to about ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... NEW YORK , Sept. 27, 2017  DarioHealth Corp. (NASDAQ: DRIO), ... solutions, today announced that its MyDario product is expected to appear on ... for when The Dr. Oz Show airs in your area: http://www.doctoroz.com/page/where-watch-dr-oz-show ... The nine-time Emmy award-winning, The Dr. ... ...
(Date:9/22/2017)... , Sept. 22, 2017 AVACEN Medical ... device is now successfully helping those with the widespread ... Fibromyalgia diagnosed Amanda in Essex, England ... and washing my hair, experiencing no sleep at all, ... painful spasm… I cannot recommend [the AVACEN 100] enough, ...
(Date:9/13/2017)... 13, 2017   OrthoAtlanta has been named the ... Host Committee (AFHC) for the 2018 College Football Playoff (CFP) ... at Mercedes-Benz Stadium in Atlanta, Georgia . ... "I,m In" campaign, participating in many activities leading up to, ... ...
Breaking Medicine Technology: