Navigation Links
Genetic Breakthrough Spells Hope for Lung Fibrosis Patients
Date:7/8/2009

Might help those with advanced disease buy time until transplant, study shows

WEDNESDAY, July 8 (HealthDay News) -- Genes that can help doctors predict when patients with idiopathic pulmonary fibrosis are becoming seriously ill have been identified by U.S. researchers, who said the findings might help keep patients alive until they can get a lung transplant.

Idiopathic pulmonary fibrosis (IPF) is a lung-scarring disease that progresses slowly and causes a gradual decline in lung function. There is no cure or effective treatment for IPF, and median survival is about three years. However, some patients experience a more rapid deterioration.

"Approximately 10 percent of patients develop an acute phase that in most cases is lethal," senior study author Dr. Naftali Kaminski said in a news release. She is director of the interstitial lung diseases center at the University of Pittsburgh School of Medicine and the University of Pittsburgh Medical Center.

In a study designed to learn more about the molecular mechanisms of accelerated IPF, the researchers compared the gene activity profile of the lungs of eight IPF patients who were experiencing dramatic worsening of their disease when they died, 23 stable IPF patients and 15 people with healthy lungs.

Differences in the expression of nearly 600 genes were noted between IPF patients with accelerated disease and those with stable disease. The researchers found no evidence that infection or inflammation was the cause of accelerated IPF. They did find signs that the cells of the alveolar epithelium, the tissue that covers the surface of the lung's air sacs, were rapidly dying.

"That could mean that drugs that are used to protect the epithelium in other illnesses, such as cancer, might help IPF patients survive an exacerbation. If we can keep them alive, there's a chance they could get a lifesaving lung transplant," study co-author Dr. Kevin Gibson, an associate professor in the pulmonary, allergy and critical care medicine division at the University of Pittsburgh School of Medicine and medical director of the interstitial lung diseases center, said in the release from the school.

The study appears in the July 15 issue of the American Journal of Respiratory and Critical Care Medicine.

More information

The U.S. National Heart, Lung, and Blood Institute has more about idiopathic pulmonary fibrosis.



-- Robert Preidt



SOURCE: University of Pittsburgh Schools of Public Health, news release, July 7, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Buyer Beware! Know What Youre Getting When You Buy Online Genetic Tests
2. Moles and melanoma -- researchers find genetic links to skin cancer
3. Another Genetic Link to Testicular Cancer Is Found
4. Interleukin Genetics Announces Strategic Divestment of Alan James Group
5. International Collaboration led by Dr. Pablo V. Gejman,Researcher At NorthShore University HealthSystem's Research Institute, Finds Genetic Association of Schizophrenia to Chromosome 6p Variant
6. Possible benefit from online genetic testing for lung cancer
7. Online Genetic Testing Appears to Have Benefits
8. Prometheus Launches MyCeliacID(TM), the First Do it Yourself, Saliva-Based Genetic Test Dedicated to Celiac Disease
9. Carnegie Mellon algorithm charts evolution of genetic networks during fruit fly life cycle
10. FDAs Current Ability to Regulate Genetic Testing is Problematic, FDLI-AAAS Colloquium Attendees Say
11. Study Finds Possible Genetic Indicator of Colorectal Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genetic Breakthrough Spells Hope for Lung Fibrosis Patients 
(Date:2/5/2016)... ... February 05, 2016 , ... Looking for a last-minute Valentine’s Day ... tips of your toes. Foot massage, whether administered by a professional masseuse or a ... The American Board of Multiple Specialties in Podiatry (ABMSP) has taken the ...
(Date:2/5/2016)... Florida (PRWEB) , ... February 05, 2016 , ... ... non-profit organization devoted exclusively to funding innovative lymphoma research and serving the lymphoma ... – is poised to once again host, Swirl, A Wine Tasting Event at ...
(Date:2/5/2016)... ... 05, 2016 , ... The American public tends to feel uncomfortable about drinking ... regular municipal or well water. The recent experience with lead contaminated water in Flint, ... long way toward increasing public acceptance of recycled waste water as drinking water. ...
(Date:2/5/2016)... ... February 05, 2016 , ... Boar’s Head Brand®, one of the ... this weekend’s Big Game. Take the stress out of your party preparation – follow ... happy at every stage of the game. , “The key to hosting a successful ...
(Date:2/5/2016)... (PRWEB) , ... February 05, 2016 , ... Dr. Justin ... announce their 2nd Annual No Cost Dental Day to individuals in need. The event ... purpose of this No Cost Dental Day is to provide dental care to community ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... Feb. 4, 2016  Edwards Lifesciences Corporation (NYSE: ... structural heart disease and critical care monitoring, announced today ... (ASR) agreement with Morgan Stanley & Co. LLC to ... is part of the Company,s previously authorized program to ... stock.  --> --> ...
(Date:2/4/2016)... , Feb. 4, 2016 Wegener ... Global Markets Direct,s, ,Wegener Polyangiitis - Pipeline ... Wegener Polyangiitis,s therapeutic pipeline. This report provides ... Polyangiitis, complete with comparative analysis at various stages, ... (MoA), route of administration (RoA) and molecule type, ...
(Date:2/4/2016)... -- Omnicell, Inc. (NASDAQ: OMCL ), a leading provider of ... announced results for its fiscal year and fourth quarter ... --> GAAP results: Revenue for the fourth quarter ... 4.1% from the third quarter of 2015, and up ... 2014. Revenue for the year ended December 31, 2015 was ...
Breaking Medicine Technology: