Navigation Links
Genetic Approach Boosts Yeast Infection Treatment
Date:10/27/2008

Inhibiting protein could yield new drug targets for mucosal fungus found in most people

MONDAY, Oct. 27 (HealthDay News) -- A new genetic approach to improve treatment of common infections caused by the yeast Candida albicans has been successfully tested by researchers at Georgetown University Medical Center.

The results confirm that inhibition of a protein produced by the Ssk1 gene could offer a new drug target against the yeast. The yeast resides in the mucous membranes of most people and causes problems such as diaper rash, vaginitis, oral infections, and invasive, blood-borne and life-threatening infections, the researchers said.

In laboratory tests, the researchers found that when the Ssk1 gene was deleted from Candida albicans, triazole drugs currently used to treat Candida-related infections were much more effective.

"This is a genetically intelligent approach to target identification and drug design," study lead author Richard Calderone, professor and chairman of the department of microbiology and immunology, and co-director of the doctoral program in the global infectious disease program at the medical center, said in a school news release.

The study was to be presented Oct. 27 at the ICAAC/IDSA annual meeting, in Washington, D.C.

"Candida infections are often treatable; however, in patients that are immunocompromised following cancer chemotherapy, bone marrow transplantation, or surgery, diagnosis is often delayed, postponing therapy," Calderone said. "Also, when drug-resistant yeast pathogens cause the infection, clinical management of the patient becomes a problem."

Candida invasive, blood-borne infections are the fourth most common hospital-acquired infection in the United States, costing the health-care system about $1.8 billion each year, Calderone said.

More information

The U.S. Centers for Disease Control and Prevention has more about Candida infections.



-- Robert Preidt



SOURCE: Georgetown University Medical Center, news release, Oct. 27, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Many Parents Share Genetic Test Findings With Kids
2. Genetic predisposition increases childhood asthma risk
3. New Alzheimers findings: High stress and genetic risk factor lead to increased memory decline
4. Test Spots Genetic Damage Done by Smoking
5. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
6. Scientists highlight benefits of genetic research in sport, but warn of ethical concerns
7. Genetics Hold Promise, Challenges for Cancer Care
8. Researchers genetically engineer micro-organisms into tiny factories
9. Study Questions Genetic Screening for Treatable Diseases
10. Researchers provide genetic associations from a genome-wide scan for cardiovascular disease traits
11. Genetic variation affects smoking cessation treatment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genetic Approach Boosts Yeast Infection Treatment
(Date:10/13/2017)... ... ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, has released ... understood books in the Holy Scriptures, Revelation. The Book of Revelation paints a picture ... Many have tossed it off as mere rubbish, but Yisrayl Hawkins says that is ...
(Date:10/12/2017)... WILMINGTON, Del. (PRWEB) , ... October 12, 2017 ... ... technology and advisory services for healthcare compliance program management, will showcase a range ... and National Association for Assisted Living (NCAL) Convention and Expo to be held ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of Medical ... Friedman, PhD, FACMI, during the Opening Session of AMIA’s Annual Symposium in Washington, D.C. ... honor of Morris F. Collen, a pioneer in the field of medical informatics, this ...
(Date:10/12/2017)... ... , ... Leading pediatric oncology experts at Children’s National Health System ... of the International Society of Paediatric Oncology (SIOP) Oct. 12-15. Chaired by ... Blood Disorders at Children’s National, and Stephen P. Hunger, M.D., Chief of the ...
(Date:10/12/2017)... ... October 12, 2017 , ... Vohra Chief ... advancements to physician colleagues, skilled nursing facility medical directors and other clinicians at ... of Wound Care." , "At many of these conferences we get to educate ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... , Oct. 12, 2017 West Pharmaceutical ... innovative solutions for injectable drug administration, today announced that ... market opens on Thursday, October 26, 2017, and will ... and business expectations at 9:00 a.m. Eastern Time. To ... 253-336-8738 (International). The conference ID is 94093362. ...
(Date:10/11/2017)...  Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), today provided ... Piedras, Puerto Rico , where the ... Following a comprehensive onsite ... structural damage, temporary loss of power and minimal water ... manufacturing operations have resumed, and the company expects to ...
(Date:10/5/2017)... 5, 2017  In response to the nationwide ... Maxillofacial Surgeons (AAOMS) released prescribing recommendations that urge ... used as a first-line therapy to manage a ... Recognizing the value and importance ... "Opioid Prescribing: Acute and Postoperative Pain Management" stresses ...
Breaking Medicine Technology: