Navigation Links
Genetic Approach Boosts Yeast Infection Treatment
Date:10/27/2008

Inhibiting protein could yield new drug targets for mucosal fungus found in most people

MONDAY, Oct. 27 (HealthDay News) -- A new genetic approach to improve treatment of common infections caused by the yeast Candida albicans has been successfully tested by researchers at Georgetown University Medical Center.

The results confirm that inhibition of a protein produced by the Ssk1 gene could offer a new drug target against the yeast. The yeast resides in the mucous membranes of most people and causes problems such as diaper rash, vaginitis, oral infections, and invasive, blood-borne and life-threatening infections, the researchers said.

In laboratory tests, the researchers found that when the Ssk1 gene was deleted from Candida albicans, triazole drugs currently used to treat Candida-related infections were much more effective.

"This is a genetically intelligent approach to target identification and drug design," study lead author Richard Calderone, professor and chairman of the department of microbiology and immunology, and co-director of the doctoral program in the global infectious disease program at the medical center, said in a school news release.

The study was to be presented Oct. 27 at the ICAAC/IDSA annual meeting, in Washington, D.C.

"Candida infections are often treatable; however, in patients that are immunocompromised following cancer chemotherapy, bone marrow transplantation, or surgery, diagnosis is often delayed, postponing therapy," Calderone said. "Also, when drug-resistant yeast pathogens cause the infection, clinical management of the patient becomes a problem."

Candida invasive, blood-borne infections are the fourth most common hospital-acquired infection in the United States, costing the health-care system about $1.8 billion each year, Calderone said.

More information

The U.S. Centers for Disease Control and Prevention has more about Candida infections.



-- Robert Preidt



SOURCE: Georgetown University Medical Center, news release, Oct. 27, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Many Parents Share Genetic Test Findings With Kids
2. Genetic predisposition increases childhood asthma risk
3. New Alzheimers findings: High stress and genetic risk factor lead to increased memory decline
4. Test Spots Genetic Damage Done by Smoking
5. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
6. Scientists highlight benefits of genetic research in sport, but warn of ethical concerns
7. Genetics Hold Promise, Challenges for Cancer Care
8. Researchers genetically engineer micro-organisms into tiny factories
9. Study Questions Genetic Screening for Treatable Diseases
10. Researchers provide genetic associations from a genome-wide scan for cardiovascular disease traits
11. Genetic variation affects smoking cessation treatment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genetic Approach Boosts Yeast Infection Treatment
(Date:12/4/2016)... , ... December 03, 2016 , ... While James Earl ... serving as host for in a show called "Front Page". One of the forthcoming ... years, breast cancer rates have plummeted in large part due to early detection. Like ...
(Date:12/4/2016)... Washington DC (PRWEB) , ... December 04, 2016 , ... ... Environmental, one of the most certified and experienced Indoor Air Quality Companies in VA, ... Assessment and Remediation Regulations. , The new mold law in the district ...
(Date:12/2/2016)... ... December 02, 2016 , ... On Dec. 2, 2016, CURE® magazine ... San Diego honoring the 2016 MPN Heroes—eight individuals who have made a difference in ... and beyond the standard of care, demonstrating leadership within the MPN community and/or a ...
(Date:12/2/2016)... ... 2016 , ... Center for Autism and Related Disorders (CARD) Portland today announced ... disorder (ASD) and other developmental disabilities. The group, which is being launched with the ... the opportunity to share stories and advice, seek help, and continue their education on ...
(Date:12/2/2016)... ... December 02, 2016 , ... ... California, will be included in the 2016 “Guide to America’s Top Plastic Surgeons” ... on the amalgamation of their education, experience, and professional associations. , One ...
Breaking Medicine News(10 mins):
(Date:12/4/2016)... 3, 2016 Johnson & Weaver, LLP announces that ... of Zimmer Biomet Holdings, Inc. (NYSE: ZBH ) ... 31, 2016 (the "Class Period"). Zimmer Biomet provides ... orthopaedic reconstructive products, such as knee and hip reconstructive products. ... , , ...
(Date:12/4/2016)...   Pairnomix, LLC, a genetic research company and ... the White House, today announced that findings from its first ... candidate therapies for a patient with epileptic encephalopathy caused by ... at the 70 th Annual Meeting of the ... , December 2-6, 2016.  Pairnomix, unique process involves ...
(Date:12/4/2016)...  Results from the Phase II SUSTAIN study show ... the median annual rate of sickle cell-related pain crises ... p=0.010) in patients with or without hydroxyurea therapy 1 ... featured in the official press briefing at the 58 ... and presented during the Plenary Scientific Session tomorrow (Abstract ...
Breaking Medicine Technology: