Navigation Links
Genes that protect against atherosclerosis identified
Date:3/14/2008

One way of combating atherosclerosis is to reduce levels of bad cholesterol in the blood. Scientists at the Swedish medical university Karolinska Institutet have now identified the genes that bring about this beneficial effect.

In a new study on mice, which is presented in the open-access journal PLoS Genetics, the research group has shown that the accumulation of the plaque that causes myocardial infarction and stroke can be prevented if levels of the bad LDL cholesterol are reduced before atherosclerotic plaque has progressed beyond a particular point. The group has also identified a network of 37 genes that lowers levels of blood cholesterol and brings about the beneficial effect.

Previously, much atherosclerosis research was focused on identifying ways to stabilise the most dangerous plaques in order to prevent them rupturing and causing myocardial infarction or stroke, says Associate Professor Johan Bjrkegren, who has led the study. Our discovery means that we can now target the actual development of dangerous plaques.

Rather than covering individual vessel wall genes, their discovery encompasses a network of genes, and one that explains their mutual interaction. It is on account of years of network algorithm development under Jesper Tegnr, professor of computational biology, that the discovery of gene networks has been made possible.

The time when individual genes or gene pathways were thought to explain the development of complex common diseases, such as atherosclerosis, is past, says Dr Bjrkegren. We now have enough tools and knowledge of system biology to take on the total complexity of these diseases.

Atherosclerosis is the main cause of myocardial infarction and stroke, which cause almost half of all deaths in Sweden and other countries in the West.


'/>"/>

Contact: Katarina Sternudd
katarina.sternudd@ki.se
46-852-483-895
Karolinska Institutet
Source:Eurekalert

Page: 1

Related medicine news :

1. Genesis Pharmaceuticals Changes Auditors
2. Cell Genesys to Present at the Cowen and Company and the Lehman Brothers Healthcare Investor Conferences
3. Cardiogenesis Corporation Announces Rescheduled Fourth Quarter and Full Year 2007 Earnings Release
4. Cardiogenesis Corporation Reports Delay in Earnings Release and Conference Call
5. Zebrafish provide useful screening tool for genes, drugs that protect against hearing loss
6. Cell Genesys Reports Fourth Quarter and Year-End 2007 Results
7. Microbial cheaters help scientists ID social genes
8. Cardiogenesis Corporation to Report 2007 Fourth Quarter and Year-End Results on March 4th
9. Thermogenesis Announces New Initiative to Address Veterinary Regenerative Medicine
10. Genesee & Wyoming Board Member Should Use Sarbanes-Oxley Disclosure Rules in Non-Profit Role, Asserts 1199 SEIU
11. 2 genes found to play crucial role in cell survival
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2017)... ... April 29, 2017 , ... Saturday, ... recognize the positive impact veterinarians have on animal health and welfare as well ... for Animal Health (OIE) choose a theme each year and this year have ...
(Date:4/28/2017)... DC (PRWEB) , ... April 28, 2017 , ... ... Pregnancy (The National Campaign) announces its support for the Access to Contraception ... Sen. Jeanne Shaheen (D-NH) and Rep. Jackie Speier (D-CA), will help to ensure ...
(Date:4/28/2017)... (PRWEB) , ... April 28, 2017 , ... It's not ... are a number of illnesses that are unclear as to whether or not they ... heads. Bronchitis is one of these illnesses. So, FindaTopDoc took a look into the ...
(Date:4/28/2017)... ... April 28, 2017 , ... Beginning in 2017, Ridgecrest ... formulas. This begins with the popular ClearLungs Extra Strength formula. To ensure that the ... formula in the following ways:, , Removal of the homeopathic ...
(Date:4/28/2017)... , ... April 28, 2017 , ... Getting enough sleep affects much more than energy ... going just 19 hours without sleep can compromise motor reaction time, which can increase the ... Amica Insurance is sharing the following tips from the NSF to help you sleep better ...
Breaking Medicine News(10 mins):
(Date:4/21/2017)... 21, 2017 Halo Labs announces the launch ... analysis system called the Horizon at PEGS 2017 in ... new system analyzes sub visible particulate matter in biopharmaceutical ... screening as early as candidate selection and pre-formulation. ... contract research organization Elion Labs for system ...
(Date:4/20/2017)... , April 20, 2017 ... "Global Biosimilar Pipeline and Market Prospects: Addressing Production ... report to their offering. ... "Global Biosimilar Pipeline and Market Prospects: ... Design" provides an in-depth assessment of the current trends ...
(Date:4/20/2017)...   ZappRx, Inc ., a digital health company focused ... announced it closed $25 million in Series B funding led ... in Seattle that is part of ... Series B round included participation from SR One , ... GV (formerly Google Ventures). As part of the financing, ...
Breaking Medicine Technology: