Navigation Links
Genes that protect against atherosclerosis identified
Date:3/14/2008

One way of combating atherosclerosis is to reduce levels of bad cholesterol in the blood. Scientists at the Swedish medical university Karolinska Institutet have now identified the genes that bring about this beneficial effect.

In a new study on mice, which is presented in the open-access journal PLoS Genetics, the research group has shown that the accumulation of the plaque that causes myocardial infarction and stroke can be prevented if levels of the bad LDL cholesterol are reduced before atherosclerotic plaque has progressed beyond a particular point. The group has also identified a network of 37 genes that lowers levels of blood cholesterol and brings about the beneficial effect.

Previously, much atherosclerosis research was focused on identifying ways to stabilise the most dangerous plaques in order to prevent them rupturing and causing myocardial infarction or stroke, says Associate Professor Johan Bjrkegren, who has led the study. Our discovery means that we can now target the actual development of dangerous plaques.

Rather than covering individual vessel wall genes, their discovery encompasses a network of genes, and one that explains their mutual interaction. It is on account of years of network algorithm development under Jesper Tegnr, professor of computational biology, that the discovery of gene networks has been made possible.

The time when individual genes or gene pathways were thought to explain the development of complex common diseases, such as atherosclerosis, is past, says Dr Bjrkegren. We now have enough tools and knowledge of system biology to take on the total complexity of these diseases.

Atherosclerosis is the main cause of myocardial infarction and stroke, which cause almost half of all deaths in Sweden and other countries in the West.


'/>"/>

Contact: Katarina Sternudd
katarina.sternudd@ki.se
46-852-483-895
Karolinska Institutet
Source:Eurekalert

Page: 1

Related medicine news :

1. Genesis Pharmaceuticals Changes Auditors
2. Cell Genesys to Present at the Cowen and Company and the Lehman Brothers Healthcare Investor Conferences
3. Cardiogenesis Corporation Announces Rescheduled Fourth Quarter and Full Year 2007 Earnings Release
4. Cardiogenesis Corporation Reports Delay in Earnings Release and Conference Call
5. Zebrafish provide useful screening tool for genes, drugs that protect against hearing loss
6. Cell Genesys Reports Fourth Quarter and Year-End 2007 Results
7. Microbial cheaters help scientists ID social genes
8. Cardiogenesis Corporation to Report 2007 Fourth Quarter and Year-End Results on March 4th
9. Thermogenesis Announces New Initiative to Address Veterinary Regenerative Medicine
10. Genesee & Wyoming Board Member Should Use Sarbanes-Oxley Disclosure Rules in Non-Profit Role, Asserts 1199 SEIU
11. 2 genes found to play crucial role in cell survival
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2016)... ... May 27, 2016 , ... In response to meager public ... unaware of the plight of aphasia. In collaboration with the American Aphasia Association, ... , The link between stroke and aphasia is relatively unknown, but through collaboration ...
(Date:5/27/2016)... ... May 27, 2016 , ... Aimed ... by inspiring human interest stories, courtesy of leaders in the nursing and health ... the industry, from leading advocates and associations—namely Jones & Bartlett Learning. , Jones ...
(Date:5/27/2016)... (PRWEB) , ... May 27, 2016 , ... ... in scholarships to students studying complementary medicine. Allison Outerbridge is this year’s ... her award on May 18 at the university’s Student Leadership Awards ceremony. , ...
(Date:5/26/2016)... ... 26, 2016 , ... Despite last week’s media reports hinting at a June ... wait until March 2017 for an interest rate increase, according to Rajeev Dhawan of ... , “The Federal Open Market Committee (FOMC) dot charts are of interest to the ...
(Date:5/26/2016)... ... , ... W.S. Badger Co. Inc ., the maker of certified organic ... Works Award for its use of effective workplace strategies to increase business and employee ... by the Families and Work Institute (FWI) and the Society for Human Resource Management ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... Calif. , May 25, 2016  Zymo ... testing for their new reference materials that help ... from sample collection to analyses. The rapid growth ... demand for researchers to have standard methods to ... being generated. Biases inherently exist at every step ...
(Date:5/25/2016)... YORK , May 25, 2016 ... Market Size, Share, Development, Growth and Demand Forecast to ... Syringe, Insulin Pump and Others)" published by P&S Market ... at $9,998.3 million in 2015, and it is expected ... Based on type, the insulin pump segment is expected ...
(Date:5/25/2016)... May 25, 2016  Granger Diagnostics today announced immediate ... wounds and infections. This test ensures discovery of ... viruses. The test requires only a simple swab of ... David G. Bostwick , MD, Chief Medical ... wound healing: "We are excited to make available, ...
Breaking Medicine Technology: