Navigation Links
Genes provide clues to gender disparity in human hearts
Date:1/24/2013

Healthy men and women show little difference in their hearts, except for small electrocardiographic disparities. But new genetic differences found by Washington University in St. Louis researchers in hearts with disease could ultimately lead to personalized treatment of various heart ailments.

Generally, men are more susceptible to developing atrial fibrillation, an irregular, rapid heartbeat that may lead to stroke, while women are more likely to develop long-QT syndrome, a rhythm disorder that can cause rapid heartbeats and sudden cardiac death.

While prior studies have clearly established differences in the development of heart disease between men and women, very few studies had looked at the molecular mechanisms behind those differences in human hearts.

Igor Efimov, PhD, the Lucy and Stanley Lopata Distinguished Professor of Biomedical Engineering in the School of Engineering & Applied Science at Washington University in St. Louis, and a former doctoral student, Christina Ambrosi, PhD, analyzed 34 human hearts looking for genetic differences that might explain gender differences in heart disease.

The team took advantage of the unique opportunity at the university to obtain failing human hearts at the time of transplantation from Barnes-Jewish Hospital and non-failing hearts unsuitable for transplantation from Mid-America Transplant Services, a St. Louis-based organ procurement service.

The team screened for 89 major genes in electrophysiology, ion channel subunits, calcium handling proteins and transcription factors important in cardiac conduction and in the development of arrhythmia and the left atria and ventricles in human hearts.

"What was striking in this study is that we expected very large gender differences in expression of genes in the ventricles, but we did not find such differences," says Efimov, also a professor of medicine, of radiology and of cell biology and physiology at Washington Univ
'/>"/>

Contact: Igor Efimov
igor@wustl.edu
314-935-8612
Washington University in St. Louis
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers ID Genes That May Determine Mental Illness
2. 2 repressor genes identified as essential for placental development
3. Genes Associated With Autism Also Related to Schizophrenia
4. Genes Might Cause Some to Shun Pork
5. Blond Genes May Vary Around the World
6. Mystery of the missing breast cancer genes
7. Living longer - variability in infection-fighting genes can be a boon for male survival
8. Genes Might Be Key to Parkinsons Spread
9. Strategy discovered to activate genes that suppress tumors and inhibit cancer
10. Study Ties Genes to Lower Urinary Tract Symptoms, Prostate Cancer Risk
11. Obesity genes may influence food choices, eating patterns
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Hawley, PA (PRWEB) January 22, 2015 Woodloch ... Pocono Mountains, has been selected by TripAdvisor as the number ... and the 6th best in the world for their annual ... online travel community . The website is home to ...
(Date:1/22/2015)... a seasoned and trusted leader who consistently delivers trendy dresses ... it lead the wedding dress industry into the future. Today, ... the global market. , “The CEO of VogueQueen is uniquely ... continuing the goal of operational excellence and giving back to ...
(Date:1/22/2015)... 2015 Blue Cross and Blue Shield of ... what it means to “Live Fearless.” , The ... share their stories about how they or someone they know ... by living in the moment. By telling these types of ...
(Date:1/22/2015)... Juvent Sports ( http://www.juventsports.com ) and David Leadbetter ... to bestow a Juvent Sports Achievement award upon an ... The award commemorated and congratulated McKitrick for her record ... her first amateur tournament in 1979 and most recently ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Autocarinsurancebest.com has released ... purchasing a commercial auto insurance policy . , Auto ... their vehicles. It is no longer necessary to call an ... are now available online on a single website: http://autocarinsurancebest.com/ ...
Breaking Medicine News(10 mins):Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 2Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 3Health News:VogueQueen Unveils New Designs of Prom Dresses for 2015 2Health News:Blue Cross and Blue Shield of Minnesota to Showcase “Faces of Fearless” 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 3Health News:Commercial Auto Insurance Provides Several Important Features! 2
... News) -- Rheumatoid arthritis patients who believe in their ... -- are more likely to reach those objectives, researchers ... who achieve their physical activity goals have lower levels ... Researchers in the Netherlands conducted an initial assessment ...
... faculty researchers and clinicians with expertise in polypharmacy, ... geriatric researcher at a free conference examining Alzheimer,s ... Medicine and Nursing join with the Greater Kentucky ... to present "The Journey: Alzheimer,s Disease and Caregiving" ...
... 2011) Bone marrow transplantation with genetically modified cells ... study led by Dr. Vivek Rangnekar, associate director of ... University of Kentucky. Bone marrow, a spongy tissue ... including leukocytes, erythrocytes and platelets. In the cover story ...
... , WEDNESDAY, Aug. 24 (HealthDay News) -- High ... fatal abnormal heart rhythms and should no longer be ... said Wednesday. Doses of Celexa (citalopram hydrobromide) greater ... the electrical activity of the heart, which can lead ...
... Aug. 24 (HealthDay News) -- U.S. teens who use social networking ... drugs and alcohol than teens with little exposure to such media, ... youths from around the nation aged 12 to 17 and about ... of teens said they used social networking sites. Social network ...
... Ont., Aug 24, 2011 More than eight out of ... and elsewhere have at least one chronic health condition and ... who are "vulnerably housed"meaning they live in unsafe, unstable or ... the survey found. The underlying cause for these health ...
Cached Medicine News:Health News:UofL experts featured at free Alzheimer's disease conference Sept. 17 2Health News:Teen Drinking, Smoking Higher Among Facebook Users: Survey 2Health News:Teen Drinking, Smoking Higher Among Facebook Users: Survey 3Health News:Study: 85 percent of homeless people have chronic health conditions 2
(Date:1/23/2015)... ORLANDO, Fla. and DUBLIN , ... of the agreement with KRS Global Biotechnology, Inc. for the ... will be compounded for shipment in the United ... 503B FDA approved Outsourcing Facility capable of compounding naltrexone tablets ...
(Date:1/23/2015)... PHILADELPHIA , Jan. 23, 2015  Pete Rose, baseball,s all-time ... joint and arthritis pain reliever Myoflex, Ducere Pharma has announced. ... and we are excited to have him on board with ... . "He is a legendary player who is known across ...
(Date:1/23/2015)... 23, 2015  Now available for sale, The Armor1 Ankle ... prevents ankle sprains by cushioning the ankle from an ... around the outside of any shoe type and allows ... still offering protection against sprains. With customers in physical ...
Breaking Medicine Technology:Immune Therapeutics, Inc. Announces Agreement with KRS Global Biotechnology, Inc. 2Immune Therapeutics, Inc. Announces Agreement with KRS Global Biotechnology, Inc. 3Immune Therapeutics, Inc. Announces Agreement with KRS Global Biotechnology, Inc. 4Pete Rose bets on Myoflex to relieve aches and pains 2The Armor1 Ankle Roll Guard is the New Breakthrough Solution for Ankle Sprain Prevention! 2
... part of the brain first,affected by Alzheimers disease ... a risk gene for the disorder, a brain,imaging ... Mental,Health (NIMH), one of the National Institutes of ... structure in the lower middle,part of the brains ...
... 25, 2007 - Reata,Pharmaceuticals, Inc. today announced ... company's Synthetic Triterpenoid programs in,the May 2007 ... The article, "Triterpenoids and rexinoids as multifunctional,agents ... by researchers,and Reata scientific collaborators from the ...
Cached Medicine Technology:Cortex Area Thinner in Youth with Alzheimers-Related Gene 2Cortex Area Thinner in Youth with Alzheimers-Related Gene 3Cortex Area Thinner in Youth with Alzheimers-Related Gene 4Reata's Synthetic Triterpenoids Profiled in Nature Reviews Cancer 2Reata's Synthetic Triterpenoids Profiled in Nature Reviews Cancer 3Reata's Synthetic Triterpenoids Profiled in Nature Reviews Cancer 4
Detection of Lupus Anticoagulants. Freeze-dried hexagonal phase phos-phatidylethanolamine; normal plasma with heparin inhibitor; PTT-LS reagent of cephalin and particulate siliceous activator;all fre...
Colorimetric Assay of Protein C Activity by STA© Analyzers. Highly purified extract of Agkistrodon c. contortrix venom for specific activation of protein C, with an activator selected specially ...
Immuno-turbidimetric assay for Free Protein Sby STA© Analyzers. Suspension of microparticles coated with monoclonal antibodies to Free Protein S....
Substrate Plasma for Factor V Assay by STA© Analyzers. Freeze-dried human plasma, artificially depleted of factor V....
Medicine Products: