Navigation Links
Genes linked to cancer could be easier to detect with liquid lasers
Date:1/31/2012

ANN ARBOR, Mich.Using a liquid laser, University of Michigan researchers have developed a better way to detect the slight genetic mutations that might predispose a person to a particular type of cancer or other diseases.

Their results are published in the current edition of the German journal Angewandte Chemie.

This work could advance understanding of the genetic basis of diseases. It also has applications in personalized medicine, which aims to target drugs and other therapies to individual patients based on a thorough knowledge of their genetic information.

The researchers say their technique works much better than the current approach, which uses fluorescent dye and other biological molecules to find and bind to mutated DNA strands. When a patrol molecule catches one of these rogues, it emits a fluorescent beacon. This might sound like a solid system, but it's not perfect. The patrol molecules tend to bind to healthy DNA as well, giving off a background glow that is only slightly dimmer than a positive signal.

"Sometimes, we can fail to see the difference," said Xudong Fan, an associate professor in the Department of Biomedical Engineering and principal investigator on the project. "If you cannot see the difference in signals, you could misdiagnose. The patient may have the mutated gene, but you wouldn't detect it."

In the conventional fluorescence technique, the signal from mutated DNA might be only a few tenths of a percent higher than the background noise. With Fan's new approach it's hundreds of times brighter.

"We found a clever way to amplify the intrinsic difference in the signals," Fan said.

He did it with a bit of backtracking.

Liquid lasers, discovered in the late '60s, amplify light by passing it through a dye, rather than a crystal, as solid-state lasers do. Fan, who works at the intersection of biomedical engineering and photonics, has been developing them for the past five years. In his unique set-up, the signal is amplified in a glass capillary called a "ring resonator cavity."

Last year, Fan and his research group found that they could employ DNA (the blueprints for life that reside in all cells) to modulate a liquid laser, or turn it on and off. His group is one of just a few in the world to accomplish this, Fan said. At the time, they didn't have a practical application in mind. Then they had an epiphany.

"We thought, 'Let's look at the laser output. Can we see what's causing the different outputs and use it to detect differences in the DNA?'" Fan said. "I had an intuition, and it turns out the output difference was huge."

The journal editors named this a "hot paper" that "advances knowledge in a rapidly evolving field of high current interest."

The paper is titled "Distinguishing DNA by Analog-to-Digital-like Conversion by Using Optofluidic Lasers." The research was funded by the National Science Foundation. The first author is Yuze Sun, a doctoral student in the Department of Biomedical Engineering. The university is pursuing patent protection for the intellectual property, and is seeking commercialization partners to help bring the technology to market.


'/>"/>

Contact: Nicole Casal Moore
ncmoore@umich.edu
734-647-7087
University of Michigan
Source:Eurekalert  

Related medicine news :

1. Mutations in 2 Genes Linked to Rare Autism-Related Disorder
2. Genes and timing of menopause
3. Inflammatory mediator promotes colorectal cancer by stifling protective genes
4. Your Taste for Fat May Reside in Your Genes
5. Tracking genes remote controls
6. Most Parents Tell Kids About Test Results for Breast Cancer Genes
7. Most parents who get tested for breast cancer genes share results with their children
8. Positive feedback and tumorigenesis
9. New book on angiogenesis from Cold Spring Harbor Laboratory Press
10. Researchers discover patterns of genes associated with timing of breast cancer recurrences
11. Genes modify the risk of liver disease among alcoholics
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genes linked to cancer could be easier to detect with liquid lasers
(Date:3/23/2017)... ... ... The physicians of KSF Orthopaedic Center PA are proud to announce the opening ... at 2255 E. Mossy Oaks Rd., Suite 440, Spring, Texas 77389 inside the new ... in the north Houston area (The Woodlands, Conroe, Magnolia, Kingwood, Humble) with an even ...
(Date:3/23/2017)... ... March 23, 2017 , ... PAINWeekEnd ... at 10 North Broadway Avenue, will be an educational and exciting program providing ... in the management of chronic pain. , Oklahoma is in a healthcare crisis. ...
(Date:3/23/2017)... ... ... of adults are unaware of the dangers that infectious bacteria play in mouth disease, while ... a day that dentists recommend. The ramifications of improper oral upkeep go far beyond bad ... 164 million hours of work each year due to dental issues. That is why Mediaplanet ...
(Date:3/23/2017)... ... March 23, 2017 , ... Benefits delivery trailblazer, ... mobile app and centralized benefits dashboard solving one of the top frustrations in ... locations. For the first time, employees can access up-to-date information and account balances ...
(Date:3/23/2017)... Malvern, PA (PRWEB) , ... March 23, 2017 ... ... a comprehensive educational training program owned and organized by HMP Communications Holdings, LLC, ... training program for physicians within its nationwide network of wound centers interested in ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... , March 23, 2017  Ethicon* today ... Medical, Inc., a privately held medical device company ... System for the surgical treatment of Gastroesophageal Reflux ... strategy of expanding its portfolio of minimally invasive ... medical conditions. Financial terms of the transaction have ...
(Date:3/23/2017)... , Mar 23, 2017 Research and Markets ... 2017-2021" report to their offering. ... The global capillary electrophoresis market to grow ... The report, Global Capillary Electrophoresis Market 2017-2021, has been prepared ... The report covers the market landscape and its growth prospects over ...
(Date:3/23/2017)... , March 23, 2017  Additive Orthopaedics, LLC., ... that it has kicked off a multi-centered clinical ... printed bone segments. According to ... variable honeycomb lattice structures have already shown tremendous ... to current allograft wedges from which we have ...
Breaking Medicine Technology: