Navigation Links
Genes identified that protect against heart damage from chemotherapy
Date:12/3/2007

A series of genes that protect cells from the powerful, common chemotherapeutic agent doxorubicin has been identified by researchers working to understand how the drug also can destroy the heart.

We found a series of genes that are very important for cell survival in the face of doxorubicin, says Dr. Hernan Flores-Rozas, cancer researcher at the Medical College of Georgia Cancer Center. At the moment you start inactivating these genes, the cells become very sensitive and dont grow any more. So now we know which genes we need to inactivate in the cell to make it very sensitive to the drug.

Doxorubicin is widely used to treat solid tumors from breast cancer to prostate and ovarian cancer. A slightly modified version, daunorubicin, is a powerful fighter of leukemia and lymphoma and often is used in children.

Unfortunately, just as cancer treatment ends, heart problems can begin for some patients who get these drugs. Heart cells, called cardiomyocytes, can commit suicide, or apoptosis, says Dr. Ling Xia, a graduate student at the Department of Cardiology at Chinas Wuhan University who is part of an exchange program with MCG. The result is dilative cardiomyopathy, in which the heart becomes a boggy organ that can no longer pump blood out to the body. Damage can even show up years after treatment, she says noting there is no known way to prevent or treat it, short of a heart transplant.

The long-term goal of their research is prevention and maybe enhanced cancer treatment through development of ways to turn these genes off in cancer cells and on in heart cells, says Dr. Flores-Rozas, corresponding author on the study published in the Dec. 1 issue of Cancer Research. Dr. Xia is first author.

Another possibility is turning down their protection in cancer cells, which should necessitate less drug and result in less heart damage, says Dr. Flores-Rozas, noting that its dose related and cumulative.

They did studies in relatively s
'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia  
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Pathway links inflammation, angiogenesis and breast cancer
2. Traffic Fumes Plus Genes Boosts Kids Asthma Risk
3. New Database to Help Speed Search for Bipolar Disorder Genes
4. Is Perfect Pitch All in the Genes?
5. Discovery suggests location of genes for breast density, a strong risk factor for breast cancer
6. Genes Boost Risk for Rheumatoid Arthritis, Lupus
7. The genes involved in rheumatoid arthritis identified
8. If you think cancer genes are simple, you dont know JAK
9. Test for lung cancer looks for discomforting quiet among protective genes
10. Hushed Genes Might Mean Higher Lung Cancer Risk
11. EURYI project to understand how the brain wires during embryogenesis
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genes identified that protect against heart damage from chemotherapy
(Date:8/1/2014)... 2014 St. Christopher's Hospital for Children ... episode of Innovations with Ed Begley Jr, airing later ... times TBA. , St. Christopher's Hospital for Children offers ... from birth through 21 years of age. With over ... hospital's specialties, including autism and childhood obesity. , ...
(Date:8/1/2014)... August 01, 2014 Narconon Arrowhead recently ... program at the drug rehab center located in the ... 2001, Narconon Arrowhead is the flagship drug rehab center ... the United States for services there. Now, with such ... recent outcome studies as well as client reviews showing ...
(Date:8/1/2014)... Arlington, TX (PRWEB) August 01, 2014 ... of the Year for its outstanding commitment to St. ... for the hospital since 1999 and pledging to raise ... to combat childhood cancer and other deadly diseases. ... from any single partner in St. Jude history. Specifically, ...
(Date:8/1/2014)... HealthDay Reporter THURSDAY, July 31, 2014 ... of heart attack and stroke, particularly if you work in ... officials reported Thursday. But being unemployed might be just ... include job stress, exposure to air pollution -- like dust ... Sara Luckhaupt, from the National Institute for Occupational Safety and ...
(Date:8/1/2014)... 01, 2014 For the first time, ... Cotton Farm & Fiber Report and the Organic Cotton ... entire organic cotton supply chain resulting in the ... organization’s Managing Director, reports, “We are looking holistically at ... the beginning of a long value chain and surveying ...
Breaking Medicine News(10 mins):Health News:Innovations with Ed Begley, Jr. to Feature St. Christopher's Hospital for Children in Upcoming Episode 2Health News:Innovations with Ed Begley, Jr. to Feature St. Christopher's Hospital for Children in Upcoming Episode 3Health News:Narconon Arrowhead Celebrates 4,300th Graduate from Program 2Health News:Narconon Arrowhead Celebrates 4,300th Graduate from Program 3Health News:St. Jude Children’s Research Hospital® Names Tri Delta Fraternity Partner of the Year 2Health News:St. Jude Children’s Research Hospital® Names Tri Delta Fraternity Partner of the Year 3Health News:Some Jobs Harder on the Heart Than Others, Report Finds 2Health News:Surveys Reveal the Top 10 Organic Cotton Users and the Top 10 Producing Countries 2
... ... shows vacations with animals will help the family bond. Spending quality time with the family often ... ... families are finding it exciting and different to spend their vacations at a Dude or Guest ...
... ... Legal Hold Pro™ service into doeDiscovery™. Further expanding doeLegal,s capabilities across the entire spectrum ... to offer increased value to all eDiscovery clients. , ... (PRWEB) May 14, 2010 -- doeLegal, ...
... essays look at ethical issues arising from new neuroimaging ... severe brain injury might be able to communicate. ... Authors: J. Andrew Billings, Larry R. Churchill, and Richard ... or a meaningful existence? The authors contend that ...
... ... luminaries in science , ... New York, NY (Vocus) May 13, 2010 -- Mount Sinai School of Medicine ... field of genetics and human genome research, and renowned humanists whose work has advanced ...
... Recognizing ... by cancer, CIGNA expands access to all Cancer Treatment Centers of America physicians and facilities. ... Chicago, IL (PRWEB) May ... customers who have been touched by cancer, CIGNA has entered into a new agreement that ...
... affects 1 in 20 people over age 65, experts ... By treating the common irregular heartbeat known as atrial ... prevent Alzheimer,s disease and other forms of dementia, new ... of the heart beat chaotically, causing blood to pool ...
Cached Medicine News:Health News:Independent Study Reveals Family Bonds made Stronger on Vacations where Animals are Involved 2Health News:Independent Study Reveals Family Bonds made Stronger on Vacations where Animals are Involved 3Health News:Independent Study Reveals Family Bonds made Stronger on Vacations where Animals are Involved 4Health News:doeLegal and Zapproved Sign Alliance to Add Legal Hold Pro to Suite of Powerful Online Legal Solutions 2Health News:doeLegal and Zapproved Sign Alliance to Add Legal Hold Pro to Suite of Powerful Online Legal Solutions 3Health News:The Hastings Center Report table of contents for May/June 2010 2Health News:The Hastings Center Report table of contents for May/June 2010 3Health News:Mount Sinai School of Medicine Commencement Honors Leaders in Genetics and Global Health 2Health News:Mount Sinai School of Medicine Commencement Honors Leaders in Genetics and Global Health 3Health News:Mount Sinai School of Medicine Commencement Honors Leaders in Genetics and Global Health 4Health News:Mount Sinai School of Medicine Commencement Honors Leaders in Genetics and Global Health 5Health News:Mount Sinai School of Medicine Commencement Honors Leaders in Genetics and Global Health 6Health News:CIGNA and Cancer Treatment Centers of America Reach New Agreement 2Health News:Treating Common Irregular Heartbeat Might Also Ward Off Alzheimer's 2Health News:Treating Common Irregular Heartbeat Might Also Ward Off Alzheimer's 3
(Date:8/1/2014)... Minn. , Aug. 1, 2014 ... medical technologies company, announced today that it has ... held manufacturer of cardiorespiratory diagnostic products based in ... MediSoft has served the European cardiorespiratory diagnostics market ... 2013 revenues of approximately €4.7 million ($6.3 million) ...
(Date:8/1/2014)... 1, 2014 Dyadic International, Inc. ("Dyadic") (OTCQX: ... technologies are used to develop, manufacture and sell enzymes ... and industrial enzyme industries, announced today that it will ... June 30, 2014 after market close on Thursday, August ... day at 5:00 p.m. Eastern Time to discuss those ...
(Date:7/31/2014)... 2014  Sorrento Therapeutics, Inc. (NASDAQ: SRNE ; ... , Chief Business Officer and Executive Vice President. Mr. Singh ... 30. "Sorrento is deeply saddened and shocked by ... thoughts go to Amar,s family and friends," said Henry ... Mr. Singh joined Sorrento in January 2014 from ...
Breaking Medicine Technology:MGC Diagnostics Corporation Completes Acquisition of MediSoft SA 2MGC Diagnostics Corporation Completes Acquisition of MediSoft SA 3MGC Diagnostics Corporation Completes Acquisition of MediSoft SA 4Dyadic International To Announce Second Quarter 2014 Financial Results And Host Conference Call On Thursday, August 14, 2014 2Dyadic International To Announce Second Quarter 2014 Financial Results And Host Conference Call On Thursday, August 14, 2014 3Sorrento Announces the Unexpected Death of its Chief Business Officer 2
... Oct. 8 Breast-Specific Gamma Imaging (BSGI), a molecular ... resonance imaging (MRI) for detecting breast carcinoma when used ... and is substantially less expensive than MRI, according to ... Oncology Breast Cancer Symposium in San Francisco, California. , ...
... Calif., Oct. 8 Endologix, Inc. (Nasdaq: ELGX ), ... that it has become aware that Cook Medical has filed ... alleging that Endologix infringes two of Cook,s U.S. patents. , ... have just become aware of the lawsuit filed by Cook ...
Cached Medicine Technology:Breast-Specific Gamma Imaging Proves Cost-Effective for Pre-Surgical Planning of Patients with Known Cancer Diagnosis 2Endologix Comments on Alleged Patent Infringement 2
The Reusable Purse String Clamp is intended for use in the mechanical construction of a purse string suture. The clamp can be used on any part of the gastrointestinal tract except the esophagus....
... VALTRAC™ Single Use Biofragmentable Anastomosis ... end-to-end, end-to-side and side-to-side anastomosis., ... and multiple intestinal anastomoses but not ... device may be used in any ...
The Auto Suture™ EEA™ 34mm reusable stainless steel sizer has application in intestinal, colorectal and esophageal surgery to help evaluate the diameter of tubular structures....
... in the parafollicular C-cells of the thyroid ... The major action of calcitonin is to ... activity, resulting in decreased mobilization of calcium ... evident in conditions associated with high levels ...
Medicine Products: