Navigation Links
Genes carried by E. coli bacteria linked to colon cancer
Date:8/16/2012

Scientists at the University of Liverpool have identified a type of E. coli bacteria that may encourage the development of colon cancer.

The Liverpool team had previously shown that people with colon cancer and with the inflammatory bowel diseases, Crohn's disease and ulcerative colitis, have high numbers of a sticky type of E. coli in their colons.

The team have now found that E. coli bacteria, which carry pks genes that encode a toxin that damages DNA in the cells of the gut lining, are more commonly found in the colons of patients that have inflammatory bowel disease and colon cancer than those that do not have these conditions. Approximately two thirds of patients with colon cancer carry these E. coli compared with one in five with a healthy colon.

Research, in collaboration with the University of North Carolina, showed that mice with colitis are more likely to carry these E. coli and they often develop colon cancer when carrying E. coli containing pks genes. They did not, however, develop cancer with identical E. coli that did not contain pks. They also found that the presence of E. coli carrying the pks genes did not appear to increase inflammation of the gut.

Professor Jonathan Rhodes, from the University's Institute of Translational Medicine, said: "The fact that the pks-positive E. coli seemed to promote colon cancer in mice without causing increased inflammation led us to investigate its possible role in human colon cancer. The marked increase in the presence of these bacteria in the colon, not only in patients with inflammatory bowel disease, but also in patients with colon cancer who do not have inflammatory bowel disease, suggests that damage caused to DNA, as a result of the toxin that the pks genes produce, may promote the development of colon cancer."

Dr Barry Campbell, co-author of the research at the University of Liverpool, said: "The research suggests that E. Coli has a much wider involvement in the development of colon cancer than previously thought. It is important to build on these findings to understand why this type of bacteria, containing the pks genes, is present in some people and not others."

The Liverpool team involved in this study were also the researchers that discovered that dietary agents, particularly plantain and broccoli, could prevent the uptake and transport of E. coli through cells in the gut. They also found that fat emulsifiers in processed food encouraged the movement of bacteria through the cells.


'/>"/>

Contact: Samantha Martin
samantha.martin@liv.ac.uk
44-015-179-42248
University of Liverpool
Source:Eurekalert

Related medicine news :

1. Researchers ID Genes That May Determine Mental Illness
2. 2 repressor genes identified as essential for placental development
3. Genes Associated With Autism Also Related to Schizophrenia
4. Genes Might Cause Some to Shun Pork
5. Blond Genes May Vary Around the World
6. Mystery of the missing breast cancer genes
7. Living longer - variability in infection-fighting genes can be a boon for male survival
8. Genes Might Be Key to Parkinsons Spread
9. Strategy discovered to activate genes that suppress tumors and inhibit cancer
10. Study Ties Genes to Lower Urinary Tract Symptoms, Prostate Cancer Risk
11. Obesity genes may influence food choices, eating patterns
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/30/2016)... , ... April 30, 2016 ... ... CBC News on April 4th, 2016 questioned the use of the HyProCure ... EOTTS-HyProCure as “a controversial procedure.” EOTTS-HyProCure is a minimally invasive procedure performed, ...
(Date:4/29/2016)... ... April 29, 2016 , ... In an article published April ... enthusiasm for Botox and lip injections, which she underwent in order to feel more ... Music and Arts Festival. The article explains that Ms. Mirmelli’s situation is not unique; ...
(Date:4/29/2016)... Georgia (PRWEB) , ... April 29, 2016 , ... On ... rural hospitals across the Southeast, celebrated the signature of Gov. Nathan Deal on SB ... Rep. Geoff Duncan (R - Cumming), offers a 70% tax credit to individuals and ...
(Date:4/29/2016)... ... 29, 2016 , ... Coast Dental Fort Stewart is celebrating its grand opening ... the Exchange Furniture Mall at 112 Vilseck Road in Fort Stewart. There will be ... attendees will have the opportunity to meet general dentists Thomas Richards, DDS, and Josh ...
(Date:4/29/2016)... ... April 29, 2016 , ... World ... the Gyrociser, an exercise invention which aids in proper muscle development. , "The ... CEO and Creative Director of World Patent Marketing. "Globalization has threatened the future ...
Breaking Medicine News(10 mins):
(Date:4/29/2016)... New Jersey , April 29, 2016 /PRNewswire/ ... Software Suite for Life Sciences, Product Development Capabilities ... Global Life Science Customer Base . ... solutions provider, today announced the acquisition of Skura ... a global leader in adaptive sales enablement technology ...
(Date:4/28/2016)...  While Abbott,s announced purchase of St. Jude ... and stent business, healthcare research firm Kalorama Information ... into patient monitoring.  Kalorama said that patient monitoring ... with double-digit growth expected the next 5 years, ... Patient Monitoring . Abbott Laboratories agreed to ...
(Date:4/28/2016)... -- Treato , the single largest ... that it has been named a Cool Vendor by ... Sciences, 2016, Stephen Davies , Michael ... life-science- oriented analytics, algorithms and smart machine technology in ... medication ingestion, and analyze unstructured information.   ...
Breaking Medicine Technology: