Navigation Links
Genes associated with aggressive breast cancer
Date:8/16/2010

Researchers at the University of Gothenburg, Sweden, have for the first time identified 12 genes that could be associated with aggressive breast tumours. The discovery could result in more reliable prognoses and better treatment strategies for patients.

The results, published in the journal Clinical Cancer Research, are based on analyses of breast tumours from 97 female breast cancer patients. Half of these patients died within eight years of diagnosis, while the remainder survived for more than eight years.

Breast tumours consist of a heterogeneous mix of tumour cells which are markedly different in terms of their genes (DNA) and biological properties. The researchers used microarray techniques to study the overall picture of the tumours by measuring the amount of DNA and gene products (RNA) in each tumour. This enabled them to investigate the relationship between genetic changes and clinical parameters such as tumour properties and response to treatment.

"We've managed to identify 12 genes whose expression is associated with an aggressive form of breast cancer," says Toshima Parris, a PhD student at the Department of Oncology. "These 12 genes were much more prominent in patients who died within eight years than in those who survived."

Three of these 12 gene products were represented in much higher levels in aggressive breast tumours than in less aggressive tumours, whereas the nine remaining genes were found in lower levels in aggressive tumours.

These findings suggest that the activity of these genes could have an effect on tumour progression by impacting cell growth, motility and development. According to Parris, it may one day be possible to test for these markers in blood samples containing circulating tumour cells and/or tumour tissue from breast cancer patients in order to ascertain whether the patient may benefit from a particular treatment or drug to counteract this change in the genes' activity.

"We hope that diagnostics focusing on these genes at an early stage will result in more reliable prognoses, which could lead to more effective treatment regimens for patients with aggressive tumours," says Parris.


'/>"/>

Contact: Toshima Parris
toshima.parris@oncology.gu.se
46-313-427-855
University of Gothenburg
Source:Eurekalert

Related medicine news :

1. Genome Studies Point to Cholesterol-Regulating Genes
2. When Others Drink, Your Genes May Lead You to Join Them
3. Breast cancer cells regulate multiple genes in response to estrogen-like compounds
4. Genes Tied to Hair Loss Disorder
5. More Genes Implicated in Type 2 Diabetes
6. The language of RNA decoded: Study reveals new function for pseudogenes and noncoding RNAs
7. New world Helicobacter pylori genome sequenced, dynamics of inflammation-related genes revealed
8. Scientists Spot More Genes Related to Alzheimers
9. Least Healthy More Apt to Think Genes Explain Disease Risk
10. Researchers report new autism genes discovered
11. Genes Link to Certain Cancers Questioned
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2016)... ... 05, 2016 , ... Linfield College Online and Continuing Education is encouraging registered ... $50 application fee for all qualified applicants from May 1–14. Students need only go ... when applying . , With the RN to BSN degree program, ...
(Date:5/5/2016)... ... 05, 2016 , ... In an effort to increase public ... health promotion and research organization, declared May as “National Sunshine Month.” , ... in cultural behavior over the past several decades, Americans spend more time indoors ...
(Date:5/4/2016)... ... May 05, 2016 , ... The talus is the part ankle that ... or traffic accidents can cause the talus bone to be fractured, and a high ... a first-of-its-kind procedure using 3D printing technology, internationally renowned orthopedic surgeon Dr. Mark ...
(Date:5/4/2016)... ... May 04, 2016 , ... The ... of its innovative kicking trainers to St. Jude Children’s Research Hospital to benefit ... durable, lightweight rubber band designed to teach children how to kick a soccer ...
(Date:5/4/2016)... ... May 04, 2016 , ... ... families of Camas and Vancouver, WA, has announced the latest beneficiary of ... Breast Cancer Foundation and their Mammography Program, which provides free mammograms and ...
Breaking Medicine News(10 mins):
(Date:5/4/2016)... Holdings (NYSE: CODI ) ("CODI," "we," "our" ... businesses, announced today its consolidated operating results for the ... Quarter 2016 Highlights , Generated Cash Flow Available ... $13.6 million for the first quarter of 2016; ... first quarter of 2016; , Paid a first ...
(Date:5/4/2016)... New York , May 4, 2016 ... by Transparency Market Research entitled "Brain Computer Interface Market - ... 2016 - 2024," the  global brain computer interface (BCI) market ... by 2024. The market is estimated to expand at ... from 2016 to 2024. A BCI device ...
(Date:5/4/2016)... , May 4, 2016  It,s time for an upgrade. There are many ... a brilliant 3.5 inch LCD, the illustrious DVMAXX HD  offers unparalleled connectivity and ... well as a world class manufacturer of innovative technology.  Photo - ... ... ...
Breaking Medicine Technology: