Navigation Links
Genes associated with aggressive breast cancer
Date:8/16/2010

Researchers at the University of Gothenburg, Sweden, have for the first time identified 12 genes that could be associated with aggressive breast tumours. The discovery could result in more reliable prognoses and better treatment strategies for patients.

The results, published in the journal Clinical Cancer Research, are based on analyses of breast tumours from 97 female breast cancer patients. Half of these patients died within eight years of diagnosis, while the remainder survived for more than eight years.

Breast tumours consist of a heterogeneous mix of tumour cells which are markedly different in terms of their genes (DNA) and biological properties. The researchers used microarray techniques to study the overall picture of the tumours by measuring the amount of DNA and gene products (RNA) in each tumour. This enabled them to investigate the relationship between genetic changes and clinical parameters such as tumour properties and response to treatment.

"We've managed to identify 12 genes whose expression is associated with an aggressive form of breast cancer," says Toshima Parris, a PhD student at the Department of Oncology. "These 12 genes were much more prominent in patients who died within eight years than in those who survived."

Three of these 12 gene products were represented in much higher levels in aggressive breast tumours than in less aggressive tumours, whereas the nine remaining genes were found in lower levels in aggressive tumours.

These findings suggest that the activity of these genes could have an effect on tumour progression by impacting cell growth, motility and development. According to Parris, it may one day be possible to test for these markers in blood samples containing circulating tumour cells and/or tumour tissue from breast cancer patients in order to ascertain whether the patient may benefit from a particular treatment or drug to counteract this change in the genes' activity.

"We hope that diagnostics focusing on these genes at an early stage will result in more reliable prognoses, which could lead to more effective treatment regimens for patients with aggressive tumours," says Parris.


'/>"/>

Contact: Toshima Parris
toshima.parris@oncology.gu.se
46-313-427-855
University of Gothenburg
Source:Eurekalert

Related medicine news :

1. Genome Studies Point to Cholesterol-Regulating Genes
2. When Others Drink, Your Genes May Lead You to Join Them
3. Breast cancer cells regulate multiple genes in response to estrogen-like compounds
4. Genes Tied to Hair Loss Disorder
5. More Genes Implicated in Type 2 Diabetes
6. The language of RNA decoded: Study reveals new function for pseudogenes and noncoding RNAs
7. New world Helicobacter pylori genome sequenced, dynamics of inflammation-related genes revealed
8. Scientists Spot More Genes Related to Alzheimers
9. Least Healthy More Apt to Think Genes Explain Disease Risk
10. Researchers report new autism genes discovered
11. Genes Link to Certain Cancers Questioned
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 27, 2016 , ... Quality metrics are proliferating in cancer ... they remain in the eye of the beholder, according to experts who offered insights ... American Journal of Managed Care. For the full issue, click here . , ...
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice Levels, ... editors can give their videos a whole new perspective by using the title ... Pixel Film Studios. , ProSlice Levels contains over 30 Different presets to choose ...
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified ... be personalized through a fitness app. The fitness app plans to fix the two major ... only offer a one size fits all type program , They don’t eliminate ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the ... AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes Convention Center in ... topics including advance care planning, healthcare costs and patient and family engagement. , ...
(Date:6/25/2016)... ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 ... brings up a new, often overlooked aspect of head lice: the parasite’s ability to live ... not a common occurrence, but a necessary one in the event that lice have simply ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 ... the "Structural Electronics 2015-2025: Applications, Technologies, Forecasts" ... In-Mold Electronics, Smart Skin, Structural ... Structural electronics involves electronic and/or ... protective structures, replacing dumb structures such as vehicle ...
(Date:6/24/2016)... -- Research and Markets has announced the addition ... report to their offering. ... The World Market for Companion Diagnostics covers the world ... in the report includes the following: , ... by Region (N. America, EU, ROW), 2015-2020 , World ...
(Date:6/24/2016)... , June 24, 2016  Arkis BioSciences, a ... invasive and more durable cerebrospinal fluid treatments, today ... The Series-A funding is led by Innova Memphis, ... and other private investors.  Arkis, new financing will ... and the market release of its in-licensed Endexo® ...
Breaking Medicine Technology: