Navigation Links
Genes associated with aggressive breast cancer
Date:8/16/2010

Researchers at the University of Gothenburg, Sweden, have for the first time identified 12 genes that could be associated with aggressive breast tumours. The discovery could result in more reliable prognoses and better treatment strategies for patients.

The results, published in the journal Clinical Cancer Research, are based on analyses of breast tumours from 97 female breast cancer patients. Half of these patients died within eight years of diagnosis, while the remainder survived for more than eight years.

Breast tumours consist of a heterogeneous mix of tumour cells which are markedly different in terms of their genes (DNA) and biological properties. The researchers used microarray techniques to study the overall picture of the tumours by measuring the amount of DNA and gene products (RNA) in each tumour. This enabled them to investigate the relationship between genetic changes and clinical parameters such as tumour properties and response to treatment.

"We've managed to identify 12 genes whose expression is associated with an aggressive form of breast cancer," says Toshima Parris, a PhD student at the Department of Oncology. "These 12 genes were much more prominent in patients who died within eight years than in those who survived."

Three of these 12 gene products were represented in much higher levels in aggressive breast tumours than in less aggressive tumours, whereas the nine remaining genes were found in lower levels in aggressive tumours.

These findings suggest that the activity of these genes could have an effect on tumour progression by impacting cell growth, motility and development. According to Parris, it may one day be possible to test for these markers in blood samples containing circulating tumour cells and/or tumour tissue from breast cancer patients in order to ascertain whether the patient may benefit from a particular treatment or drug to counteract this change in the genes' activity.


'/>"/>
Contact: Toshima Parris
toshima.parris@oncology.gu.se
46-313-427-855
University of Gothenburg
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Genome Studies Point to Cholesterol-Regulating Genes
2. When Others Drink, Your Genes May Lead You to Join Them
3. Breast cancer cells regulate multiple genes in response to estrogen-like compounds
4. Genes Tied to Hair Loss Disorder
5. More Genes Implicated in Type 2 Diabetes
6. The language of RNA decoded: Study reveals new function for pseudogenes and noncoding RNAs
7. New world Helicobacter pylori genome sequenced, dynamics of inflammation-related genes revealed
8. Scientists Spot More Genes Related to Alzheimers
9. Least Healthy More Apt to Think Genes Explain Disease Risk
10. Researchers report new autism genes discovered
11. Genes Link to Certain Cancers Questioned
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2015)... ... 2015 , ... Targeted therapies, made possible by a growing ... according to a newly published report. Surviving Mesothelioma has more on the findings ... The authors of the new paper focus on several types of targeted approaches ...
(Date:8/29/2015)... ... 2015 , ... People who have heart or lung diseases, ... are at higher risk from wildfire smoke especially in Calgary, Alberta.Those with existing ... (arrhythmia or irregular heartbeat) are also sensitive to air pollution. , Tiny ...
(Date:8/28/2015)... ... August 28, 2015 , ... ... Decatur County Memorial Hospital recently transitioned management companies to partner with Wound Care ... for their outpatient wound center. , Transitioning wound care management providers can ...
(Date:8/28/2015)... ... ... With the goal of furthering music education programs in schools, the “Music ... Fairgrounds in Mendon, IL on May 30th, 2015. Backed once again by Best Drug ... underfunded school districts of Mendon and its neighboring town of Quincy, IL. Best Drug ...
(Date:8/28/2015)... (PRWEB) , ... August 28, 2015 , ... On May ... Michigan, joined as sponsor of the “Music With A Mission” benefit concert in Mendon, ... the event was to raise money to support music education programs in the underfunded ...
Breaking Medicine News(10 mins):Health News:Top Mesothelioma Researchers Highlight Targeted Therapies in New Report, According to Surviving Mesothelioma 2Health News:Heart Fit Clinic Sounds the Alarm on Forest Fire Smoke and Chronic Heart Disease in Calgary Area 2Health News:Decatur County Memorial Hospital Transitions Wound Center Management To Wound Care Advantage and the Luvo Operating System 2Health News:Decatur County Memorial Hospital Transitions Wound Center Management To Wound Care Advantage and the Luvo Operating System 3Health News:Decatur County Memorial Hospital Transitions Wound Center Management To Wound Care Advantage and the Luvo Operating System 4Health News:Best Drug Rehabilitation Interviews Country-Rock Duo Highway Run at the 2015 "Music With A Mission" Benefit Concert 2Health News:New Video Released on "Music With A Mission" Benefit Concert Headlining Artist Cadillac Three & Best Drug Rehabilitation 2
... A Danish study had reported that children in their teens ... to the harsh glare of the sun. // In the ... researchers had asked 340 volunteers to wear a wristwatch that ... UVR doses. ,The volunteers of the study included ...
... and Japan have been able to identify a type ... //beings awake. By tracking the nerve cells in rats, ... neuron receives inhibitory signals during night that makes them ... a chemical called orexin that keeps the animal awake. ...
... that increased exposure to infections in early infancy, as ... of developing acute lymphoblastic leukemia. ,The study results ... UK of age 2 to 14 yrs without cancer ... acute lymphoblastic leukemia. Day care and social activities were ...
... Medical School said that intake of calcium supplements over ... people at risk of colon cancer.// ,Calcium ... pre-cancerous polyp formations in colon. Calcium has chemo protective ... ,The previous study was in a trial, which ...
... Athletes who drink water during long distance running events ... much water // is almost as bad for health ... says the study researchers of UT Southwestern Medical Center, ... long race may lead to a condition called hyponatremia. ...
... have found out that having green tea catechins for a ... in males.// ,Of the 32 people who were ... only one person developed the cancer. They all had been ... the property of green tea catechins or a component of ...
Cached Medicine News:
(Date:8/28/2015)... SOUTH SAN FRANCISCO, Calif. , Aug. 28, 2015 ... therapeutics for the treatment of cancer, today announced the ... the U.S. Securities and Exchange Commission (SEC) relating to ... The number of shares to be offered and the ... determined. CytomX intends to list its common stock under ...
(Date:8/28/2015)... -- Research and Markets ( ... "Investigation Report on China,s Pranoprofen Market, 2010-2019" ... discovered by Welfide (Mitsubishi Tanabe Pharma Corporation formerly ... inflammatory drug, pranoprofen was later developed into eye ... trade name of pranopulin for the treatment of ...
(Date:8/28/2015)... , Aug. 28, 2015 ... has announced the addition of the "12th ... and Production" report to their offering. ... of Biopharmaceutical Manufacturing Capacity and Production is the ... manufacturing organizations, current and projected future capacity and ...
Breaking Medicine Technology:CytomX Files Registration Statement for Proposed Initial Public Offering 2Investigation Report on China's Pranoprofen Market, 2010-2019 212th Annual Report and Survey of Biopharmaceutical Manufacturing Capacity and Production 2
... (NASDAQ: PRXL ), a leading global biopharmaceutical ... appointed several executives to its global team of ... in PAREXEL,s PACE™ (Peri-Approval Clinical Excellence) group. This team ... to prove the value of their products to multiple ...
... 2011 Biodesix today announced  that results from a ... phase III study, EGF30008, will be presented at the ... The purpose of the study was to evaluate the ... outcomes following treatment with either Femara ® or Femara ...
Cached Medicine Technology:PAREXEL Strengthens Late Phase and Observational Research Capabilities With Expert Team to Help Biopharma Meet Commercialization Goals 2PAREXEL Strengthens Late Phase and Observational Research Capabilities With Expert Team to Help Biopharma Meet Commercialization Goals 3PAREXEL Strengthens Late Phase and Observational Research Capabilities With Expert Team to Help Biopharma Meet Commercialization Goals 4PAREXEL Strengthens Late Phase and Observational Research Capabilities With Expert Team to Help Biopharma Meet Commercialization Goals 5Biodesix Announces New VeriStrat® Data to be Presented at the 34th Annual CTRC-AACR San Antonio Breast Cancer Symposium 2Biodesix Announces New VeriStrat® Data to be Presented at the 34th Annual CTRC-AACR San Antonio Breast Cancer Symposium 3
Knowles Pins are available in 9" (228mm) overall length with 9/64" (3.5mm) shaft diameter and 1/4" (6.4mm) square bead....
... Calibrated Guide Wires are available in two ... 9 in. length. Material: DePuy certified stainless ... ,Smooth wires etched in 1/2 in. ... also available. Etched in 1/2 in. ...
Kirschner Wires are available in four point styles ranging from .028 to .062 in. Smooth tip wire available in 4, 6 and 9 in. lengths. Threaded tip available. Material: DePuy certified stainless steel...
... Non-Donor Supplemental: Calypte Biomedical ... HIV-1 antibody testing algorithm as well ... Western Blot Kit [Human Immunodeficiency Virus ... products represent a portfolio of established ...
Medicine Products: