Navigation Links
Genes associated with aggressive breast cancer

Researchers at the University of Gothenburg, Sweden, have for the first time identified 12 genes that could be associated with aggressive breast tumours. The discovery could result in more reliable prognoses and better treatment strategies for patients.

The results, published in the journal Clinical Cancer Research, are based on analyses of breast tumours from 97 female breast cancer patients. Half of these patients died within eight years of diagnosis, while the remainder survived for more than eight years.

Breast tumours consist of a heterogeneous mix of tumour cells which are markedly different in terms of their genes (DNA) and biological properties. The researchers used microarray techniques to study the overall picture of the tumours by measuring the amount of DNA and gene products (RNA) in each tumour. This enabled them to investigate the relationship between genetic changes and clinical parameters such as tumour properties and response to treatment.

"We've managed to identify 12 genes whose expression is associated with an aggressive form of breast cancer," says Toshima Parris, a PhD student at the Department of Oncology. "These 12 genes were much more prominent in patients who died within eight years than in those who survived."

Three of these 12 gene products were represented in much higher levels in aggressive breast tumours than in less aggressive tumours, whereas the nine remaining genes were found in lower levels in aggressive tumours.

These findings suggest that the activity of these genes could have an effect on tumour progression by impacting cell growth, motility and development. According to Parris, it may one day be possible to test for these markers in blood samples containing circulating tumour cells and/or tumour tissue from breast cancer patients in order to ascertain whether the patient may benefit from a particular treatment or drug to counteract this change in the genes' activity.

"We hope that diagnostics focusing on these genes at an early stage will result in more reliable prognoses, which could lead to more effective treatment regimens for patients with aggressive tumours," says Parris.


Contact: Toshima Parris
University of Gothenburg

Related medicine news :

1. Genome Studies Point to Cholesterol-Regulating Genes
2. When Others Drink, Your Genes May Lead You to Join Them
3. Breast cancer cells regulate multiple genes in response to estrogen-like compounds
4. Genes Tied to Hair Loss Disorder
5. More Genes Implicated in Type 2 Diabetes
6. The language of RNA decoded: Study reveals new function for pseudogenes and noncoding RNAs
7. New world Helicobacter pylori genome sequenced, dynamics of inflammation-related genes revealed
8. Scientists Spot More Genes Related to Alzheimers
9. Least Healthy More Apt to Think Genes Explain Disease Risk
10. Researchers report new autism genes discovered
11. Genes Link to Certain Cancers Questioned
Post Your Comments:
(Date:11/27/2015)... , ... November 27, 2015 , ... Dr. Thomas ... Associates, Inc. and Dr. Tucker Bierbaum with Emergency Medicine at St., Joseph ... that both STEMI and Sepsis conditions present in similar ways and require time-critical intervention ...
(Date:11/26/2015)... ... 26, 2015 , ... Patients at Serenity Point Recovery, a ... on Thanksgiving Day to share the things that they are most grateful for ... YouTube channel, patients displayed what they wrote on index cards, describing the things ...
(Date:11/26/2015)... ... 26, 2015 , ... Somu Sivaramakrishnan announced today that he ... now offers travelers, value and care based Travel Services, including exclusive pricing on ... as, cabin upgrades and special amenities such as, shore excursions, discounted fares, travel ...
(Date:11/26/2015)... TX (PRWEB) , ... November 26, 2015 , ... PRMA ... On November 19, 2015, our surgeons performed their 6,000th free flap breast reconstruction surgery! ... “We wake up every day excited to rebuild lives and it’s an honor to ...
(Date:11/26/2015)... ... November 26, 2015 , ... ... health and wellness consultation, has collaborated with Women’s Web – an online ... queries on topics on mental and emotional well-being relationship, life balance, stress, ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... , November 26, 2015 ... addition of the "2016 Future Horizons ... of Abuse Testing Market: Supplier Shares, Country ... report to their offering. --> ... the "2016 Future Horizons and Growth ...
(Date:11/26/2015)... Nov. 26, 2015 Research and Markets ( ... "Advanced Wound Care Market by Type (Dressings, Therapy Devices, ... (In-Patient Facility, Out-Patient Facility), and Geography - Global Forecast ... --> --> The purpose ... and forecast of the global advanced wound care market. ...
(Date:11/26/2015)... India , November 26, 2015 ... --> adds ... Report" and "Investigation Report on China ... and 2021 forecasts data and information ... . ...
Breaking Medicine Technology: