Navigation Links
Genes and Early Wheezing Tied to Childhood Asthma Risk
Date:3/27/2013

WEDNESDAY, March 27 (HealthDay News) -- Certain genetic factors and wheezing early in life are associated with a greatly increased risk of asthma in children, a new study says.

Researchers examined data from nearly 500 children and found that about 90 percent of those who had two copies of a common genetic variation and who also experienced wheezing when they had a cold early in life developed asthma by age 6.

These children, all from families with a history of asthma or allergies, were nearly four times more likely to develop asthma than those who did not have the genetic variation and did not wheeze, according the study in the March 28 issue of the New England Journal of Medicine.

The genetic variation is found on chromosome 17 and is common. Half of the children in the study had one copy and 25 percent had two copies. The researchers also noted that colds are extremely common and affect nearly all infants.

The increased risk is associated with wheezing during colds caused by a human rhinovirus infection, the University of Chicago Medical Center researchers said.

"We found that the interaction between this specific wheezing illness and a gene or genes on a region of chromosome 17 determines childhood asthma risk," study author Carole Ober, a professor of human genetics at the University of Chicago, said in a medical center news release. "The combination of genetic predisposition and the child's response to this infection has a huge effect."

The researchers said it is not clear how this gene variation and wheezing interact to increase the risk of developing asthma. It also should be noted that the research showed only an association between them, and not a cause-and-effect relationship.

About 25 percent of children who had no wheezing from a human rhinovirus infection developed asthma, and 40 percent of those who experienced wheezing in the first three years of life but lacked the risk-related gene variants developed asthma.

That rose to nearly 60 percent among those with one copy of the gene variant and to 90 percent for those with two copies.

More information

The American Lung Association has more about children and asthma.

-- Robert Preidt

SOURCE: University of Chicago Medical Center, news release, March 27, 2013


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Researchers ID Genes That May Determine Mental Illness
2. 2 repressor genes identified as essential for placental development
3. Genes Associated With Autism Also Related to Schizophrenia
4. Genes Might Cause Some to Shun Pork
5. Blond Genes May Vary Around the World
6. Mystery of the missing breast cancer genes
7. Living longer - variability in infection-fighting genes can be a boon for male survival
8. Genes Might Be Key to Parkinsons Spread
9. Strategy discovered to activate genes that suppress tumors and inhibit cancer
10. Study Ties Genes to Lower Urinary Tract Symptoms, Prostate Cancer Risk
11. Obesity genes may influence food choices, eating patterns
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genes and Early Wheezing Tied to Childhood Asthma Risk
(Date:5/27/2016)... ... May 27, 2016 , ... With a ... medical and food industries. Aside from its GMP accreditation, Validation Center is also ... successfully certified products, services and staff. , Validation Center is ISO17025 accredited and ...
(Date:5/26/2016)... ... ... There are many ways to cook a hot dog, but new research ... their dogs straight off the grill. Of the 90 percent of Americans who say ... a hot dog, far outpacing other cooking methods such as steaming (12 percent), microwaving ...
(Date:5/26/2016)... California (PRWEB) , ... May 26, 2016 , ... ... associated with discovery of thousands of defective respirators, according to court documents and ... the case of William and Becky Tyler v. American Optical Corporation, Case No. ...
(Date:5/26/2016)... ... May 26, 2016 , ... Georgia State University College of ... programs. , Answering to the increasing demand for curricular specializations, the Certificate in ... environmental and land use law. ,  , “The demand for lawyers with specific ...
(Date:5/26/2016)... ... ... On Memorial Day, Hope For Heroes and USA Medical Card ... the country. The nonprofit Hope For Heroes partnered with the leading provider of ... disabled military veterans, as well as police, firemen, and EMS professionals across the country, ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... Inivata, a global clinical ... tumour DNA (ctDNA) analysis to improve personalised healthcare ... Clive Morris as Chief Medical Officer. ... development programme, scientific collaborations, and through to commercialisation ... in clinical outcomes for patients. Clive ...
(Date:5/24/2016)... --   , Study met ... cleansing and superiority in , Excellent ... of the ascending colon   , ... Norgine B.V. today announced new positive data from the phase III ... versus standard 2 litre PEG with ascorbate. The study met both ...
(Date:5/24/2016)... , May 24, 2016  Joe Marziani has joined VMS BioMarketing as senior ... executive officer, today. In his new role, Marziani will lead the company,s business development ... professionals to improve outcomes. Photo - http://photos.prnewswire.com/prnh/20160523/371089 ... ... ...
Breaking Medicine Technology: