Navigation Links
Genes and Early Wheezing Tied to Childhood Asthma Risk
Date:3/27/2013

WEDNESDAY, March 27 (HealthDay News) -- Certain genetic factors and wheezing early in life are associated with a greatly increased risk of asthma in children, a new study says.

Researchers examined data from nearly 500 children and found that about 90 percent of those who had two copies of a common genetic variation and who also experienced wheezing when they had a cold early in life developed asthma by age 6.

These children, all from families with a history of asthma or allergies, were nearly four times more likely to develop asthma than those who did not have the genetic variation and did not wheeze, according the study in the March 28 issue of the New England Journal of Medicine.

The genetic variation is found on chromosome 17 and is common. Half of the children in the study had one copy and 25 percent had two copies. The researchers also noted that colds are extremely common and affect nearly all infants.

The increased risk is associated with wheezing during colds caused by a human rhinovirus infection, the University of Chicago Medical Center researchers said.

"We found that the interaction between this specific wheezing illness and a gene or genes on a region of chromosome 17 determines childhood asthma risk," study author Carole Ober, a professor of human genetics at the University of Chicago, said in a medical center news release. "The combination of genetic predisposition and the child's response to this infection has a huge effect."

The researchers said it is not clear how this gene variation and wheezing interact to increase the risk of developing asthma. It also should be noted that the research showed only an association between them, and not a cause-and-effect relationship.

About 25 percent of children who had no wheezing from a human rhinovirus infection developed asthma, and 40 percent of those who experienced wheezing in the first three years of life but lacked the risk-related gene variants developed asthma.

That rose to nearly 60 percent among those with one copy of the gene variant and to 90 percent for those with two copies.

More information

The American Lung Association has more about children and asthma.

-- Robert Preidt

SOURCE: University of Chicago Medical Center, news release, March 27, 2013


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Researchers ID Genes That May Determine Mental Illness
2. 2 repressor genes identified as essential for placental development
3. Genes Associated With Autism Also Related to Schizophrenia
4. Genes Might Cause Some to Shun Pork
5. Blond Genes May Vary Around the World
6. Mystery of the missing breast cancer genes
7. Living longer - variability in infection-fighting genes can be a boon for male survival
8. Genes Might Be Key to Parkinsons Spread
9. Strategy discovered to activate genes that suppress tumors and inhibit cancer
10. Study Ties Genes to Lower Urinary Tract Symptoms, Prostate Cancer Risk
11. Obesity genes may influence food choices, eating patterns
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genes and Early Wheezing Tied to Childhood Asthma Risk
(Date:10/13/2017)... ... 13, 2017 , ... Ellevate Network, the leading network for professional women, brought ... gender equality at their inaugural Summit in New York City in June. The event ... audience of over 3 million. To watch the Mobilize Women video, click here ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a leader ... been awarded a contract by the Center for Medicare and Medicaid Services (CMS). ... the enterprise use of Agile methodologies in a consistent and high value manner ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and San Francisco ... using cutting-edge Oventus O2Vent technology. As many as 18 million Americans are estimated ... in breathing. Oral appliances can offer significant relief to about 75 percent of ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of Medical Informatics (ACMI) ... FACMI, during the Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s ... Morris F. Collen, a pioneer in the field of medical informatics, this prestigious award ...
(Date:10/12/2017)... ... October 12, 2017 , ... HMP , a leader in healthcare ... Folio Magazine Eddie Digital Award for ‘Best B-to-B Healthcare Website.’ Winners were announced during ... , The annual award competition recognizes editorial and design excellence across a range of ...
Breaking Medicine News(10 mins):
(Date:10/7/2017)... --  Provista, a proven leader in the supply ... power, today announced a new resource area on Provistaco.com ... is the online home for case studies, articles on ... releases, slideshows and events. ... at their fingertips, viewers can also watch short videos ...
(Date:10/4/2017)... WESTWOOD, Mass. , Oct. 4, 2017  According to the Centers ... by the end of October . PhysicianOne Urgent Care is helping communities ... Westchester, NY , by offering no-cost* flu shots through ... , as mandated by certain health insurance regulations. ... The best time to get a flu shot is by ...
(Date:10/2/2017)... INDIANAPOLIS , Oct. 2, 2017  Eli Lilly ... its financial results for the third quarter of 2017 ... a conference call on that day with the investment ... performance. The conference call will begin at ... public can access a live webcast of the conference ...
Breaking Medicine Technology: