Navigation Links
Genes Yield More Clues to Schizophrenia

9 genetic markers play a role, and the condition can be inherited from both parents, scientists say

WEDNESDAY, Dec. 5 (HealthDay News) -- A U.S. team has spotted nine genetic markers that can increase a person's risk for schizophrenia.

They've also found evidence that the condition can be inherited in what geneticists call a "recessive" manner -- inherited from both parents.

"If a person inherits identical copies of these markers from each parent, his or her risk for schizophrenia increases substantially," lead author Todd Lencz, director of research at the Zucker Hillside Hospital campus of the Feinstein Institute for Medical Research in Glen Oaks, N.Y., explained in a prepared statement.

The study was published this week in the journal Proceedings of the National Academy of Sciences.

"If these results are confirmed, they could open up new avenues for research in schizophrenia and severe mental illness" study senior investigator Dr. Anil Malhotra, director of psychiatric research at Zucker Hillside, said in a prepared statement.

For this study, the researchers developed a unique mathematical method to simultaneously examine genetic information that a person has inherited from both parents, identifying identical pieces of chromosomes.

The scientists tested genetic material from 178 people with schizophrenia and a control group of 144 people without the condition. They identified nine regions along the chromosomes that may play a major role in triggering schizophrenia when two identical variants are inherited from parents.

Four of these regions contain genes previously linked to schizophrenia. The five other regions are new. Many of the genes in these regions play a role in the structure and survival of neurons.

The researchers found that 81 percent of schizophrenia patients in the study had at least one of the recessive markers, compared to 45 percent of those in the control group. Almost half the schizophrenia patients had two or more recessive markers, compared to 11 percent of those in the control group.

More information

Mental Health America has more about schizophrenia.

-- Robert Preidt

SOURCE: Feinstein Institute for Medical Research, news release, Dec. 3, 2007

Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Pathway links inflammation, angiogenesis and breast cancer
2. Traffic Fumes Plus Genes Boosts Kids Asthma Risk
3. New Database to Help Speed Search for Bipolar Disorder Genes
4. Is Perfect Pitch All in the Genes?
5. Discovery suggests location of genes for breast density, a strong risk factor for breast cancer
6. Genes Boost Risk for Rheumatoid Arthritis, Lupus
7. The genes involved in rheumatoid arthritis identified
8. If you think cancer genes are simple, you dont know JAK
9. Test for lung cancer looks for discomforting quiet among protective genes
10. Hushed Genes Might Mean Higher Lung Cancer Risk
11. EURYI project to understand how the brain wires during embryogenesis
Post Your Comments:
(Date:11/27/2015)... ... November 27, 2015 , ... ... software Q-Suite, announces the incorporation of Asterisk 11 LTS (Long Term Support) into ... Asterisk 11 LTS brings Q-Suite 5.10 up-to-date with a version of Asterisk that ...
(Date:11/26/2015)... ... , ... Inevitably when people think Thanksgiving, they also think Holiday sales and ... Friday and Cyber Monday massage chair sales to receive the best pricing ... to find the best massage chair deals, they can see all of the coupons ...
(Date:11/26/2015)... Ashburn, VA (PRWEB) , ... November 26, 2015 ... ... Planners, an American Express Travel Representative. As a franchise owner, Somu now offers ... range of cruise, destination wedding packages, private cruise sales, as well as, cabin ...
(Date:11/26/2015)... ... 26, 2015 , ... Jobs in hospital medical laboratories and in the imaging ... staffing agency Aureus Medical Group . These fields, as well as ... searching for healthcare jobs through the company’s website, , The leading ...
(Date:11/26/2015)... ... 26, 2015 , ... WorldCare International, Inc., the first company ... Employee Benefits Conference. The Employee Benefits Conference was hosted by the International Foundation ... 11th, 2015. The conference was held at the Hawaii Convention Center in Honolulu, ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... DUBLIN , Nov. 26, 2015 ... the addition of the "2016 Future Horizons ... Monitoring (TDM) Market: Supplier Shares, Country Segment Forecasts, ... offering. --> ... comprehensive analysis of the Japanese therapeutic drug monitoring ...
(Date:11/26/2015)... , November 26, 2015 ... of the "2016 Future Horizons and ... Abuse Testing Market: Supplier Shares, Country Segment ... to their offering. --> ... "2016 Future Horizons and Growth Strategies ...
(Date:11/26/2015)... DUBLIN , November 26, 2015 ... has announced the addition of the  ... in the European Therapeutic Drug Monitoring ... Forecasts, Competitive Intelligence, Emerging Opportunities"  report ... ) has announced the addition ...
Breaking Medicine Technology: