Navigation Links
Genes Tied to Severity of Cystic Fibrosis Identified

SUNDAY, May 22 (HealthDay News) -- The severity of cystic fibrosis, a life-threatening hereditary condition that affects the lungs and digestive system, seems to be influenced by genetic variations, researchers have found.

"Most cystic fibrosis patients born today live to their mid-30s, but that's an average. Some succumb to the disease before their 10th birthday, while others live into their 50s and we wanted to know why," Dr. Garry Cutting, a professor of pediatrics and member of the McKusick-Nathans Institute for Genetic Medicine at Johns Hopkins, said in a Hopkins news release.

The study, published online in Nature Genetics, used DNA from 3,467 patients -- including unrelated patients from the Genetic Modifier Study out of the University of North Carolina at Chapel Hill, the Canadian Consortium for Genetic Studies out of the University of Toronto, and related patients and their parents from the CF Twin and Sibling Study at Johns Hopkins.

The researchers hope their findings will help extend the life expectancy of people with the disease. "To achieve this goal, we had to work together as one group," Cutting said.

The investigators from all three studies collaborated and analyzed 600,000 sites of variation within the genome in search of common variations that are more frequently associated with severe cases of cystic fibrosis.

The result: The researchers were able to identify a region encompassed by two genes on chromosome 11 linked to severe cases of the disease. A second region on chromosome 20 was also identified. Continued study of this region revealed five genes that are turned on in respiratory cells, some of which are known to cause inflammation.

"We already know which gene causes cystic fibrosis, but to a large extent that gene does not by itself explain how severe the condition will be," explained Cutting. "Now we've discovered new genes that influence the course of disease and may enable prediction of disease severity and, most importantly, the customization of treatments for patients with unfavorable genetic modifiers -- this is the realization of individualized medicine," he added.

The investigators pointed out that further studies are needed to determine exactly how these genes alter the severity of cystic fibrosis.

"Of course we want to continue to push the median life expectancy up so that hopefully patients with more severe cases of cystic fibrosis will, with multimodal therapy, survive longer. And this is the first step toward developing such therapies for these patients," Cutting concluded.

More information

The Cystic Fibrosis Foundation provides detailed information on the symptoms and treatment for cystic fibrosis.

-- Mary Elizabeth Dallas

SOURCE: Johns Hopkins Medicine, news release, May 22, 2011

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Outstanding quality of science at 6th IAS Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2011) underlines conference goal of translating HIV research into practice
2. Genes May Affect Whether People Heed Advice
3. CSHL team perfects non-lethal way of switching off essential genes in mice
4. Certain Genes Could Add to Alcoholism Risk
5. Discovery of 2 new genes provides hope for stemming Staph infections
6. Coffee Addiction May Be Grounded in Genes
7. Study provides first link between 2 major Parkinsons genes
8. Scientists Spot 4 New Alzheimers Genes
9. Understanding Alzheimer’s: Genetic search uncovers five new genes
10. Different genes influence smoking risk during adolescence and adulthood
11. Genes relate to level of alcohol consumption among Asians
Post Your Comments:
Related Image:
Genes Tied to Severity of Cystic Fibrosis Identified
(Date:11/25/2015)... Missouri (PRWEB) , ... November 25, 2015 , ... ... HEAL, will provide scholarships for people struggling with eating disorders as a result ... from the second annual event, held at Fox Run Golf Club in Eureka, ...
(Date:11/25/2015)... ... November 25, 2015 , ... An unlikely combination of recycled ... way for homeless people to have a more dignified and comfortable night’s sleep. ... they are repurposing plastic bags into sleeping mats for the homeless. The ...
(Date:11/25/2015)... ... November 25, 2015 , ... Students and parents have something ... winners of the Create Real Impact awards. California Casualty is proud to ... the tide of distracted and reckless driving, the number one killer of young drivers. ...
(Date:11/24/2015)... ... ... Dr. Todd S. Afferica, a noted general dentist in Norcross, GA , ... now uses the BIOLASE WaterLase iPlus 2.0™ in many of his dental procedures. This ... cutting tools, such as the scalpel and high-speed drill, which can both cause patients ...
(Date:11/24/2015)... ... November 24, 2015 , ... ThirdLove, the ... sale a week early, offering 40% off select bras and underwear styles, now ... through both mobile fit technology and the latest fashion, quickly becoming the next ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)...  Array BioPharma Inc. (Nasdaq: ARRY ) ... Ron Squarer , will present at the Piper ... public is welcome to participate in the conference ... Jaffray Annual Healthcare ConferencePresenter:  , Ron Squarer, Chief ... Eastern Time Webcast: , ...
(Date:11/24/2015)... NEWPORT NEWS, Va. , Nov. 24, 2015 /PRNewswire/ ... that they have signed an agreement for DILON to ... select geographies across the globe. The signing of this distribution ... GE,s Discovery NM750b Molecular Breast Imaging system and is ... ways to provide better healthcare solutions for clinicians and ...
(Date:11/24/2015)... 2015 . ... adds Latest Guidebook for Chinese Medical Device GMP ... in November 2015 to the medical devices market ... at . China ... global economies with a fifth population in the ...
Breaking Medicine Technology: