Navigation Links
Genes Tie Blood Fat to Heart Disease
Date:5/6/2010

Mutation can increase risk by up to 40 percent, researchers say

THURSDAY, May 6 (HealthDay News) -- Scientists have long debated the role triglyceride levels might play in heart disease, and finally they have genetic evidence linking high concentrations of the blood fat to an increased risk of heart trouble.

Until now, cholesterol levels were the key targets of heart disease prevention efforts, but experts say a new report in the May 8 issue of The Lancet may revise that thinking.

Triglycerides, a major source of human energy, are produced by the liver or derived from foods. "Despite several decades of research, it has remained uncertain whether raised levels of triglyceride can cause heart disease," said lead researcher Nadeem Sarwar, a lecturer in cardiovascular epidemiology at the University of Cambridge in England.

"We found that people with a genetically programmed tendency for higher triglyceride levels also had a greater risk of heart disease," Sarwar said. "This suggests that triglyceride pathways may be involved in the development of heart disease."

To explore a genetic link between triglycerides and heart disease, Sarwar's team collected data on 302,430 people who participated in 101 studies. "We employed novel genetic approaches -- so-called 'Mendelian randomization analysis,'" he said.

Specifically, the researchers looked at mutations in the apolipoprotein A5 gene, a known determinant of triglyceride concentrations. They found that for every copy of the variant, there was a 16 percent increase in triglyceride concentrations, so two copies increased triglyceride levels 32 percent.

People with two such variants had a 40 percent increased risk of developing heart disease, the researchers calculated.

Although these genetic findings indicate a causative role for triglyceride pathways in the development of heart disease, they do not replace the need for large randomized clinical trials of medications that lower blood triglyceride levels, Sarwar said.

Such trials should help establish whether reducing triglyceride concentration can reduce the risk of heart disease, he said. "There are several medications currently available or under development that can influence blood triglyceride levels," he noted.

Drug maker Novartis, the British Heart Foundation and the UK Medical Research Council funded the study.

Dr. Gregg C. Fonarow, a professor of cardiovascular medicine and director of the Ahmanson-UCLA Cardiomyopathy Center at the University of California, Los Angeles, also said more research is needed.

"Elevated LDL cholesterol has been definitively established as a major modifiable cardiovascular risk factor," he said. "There is also strong evidence that low levels of HDL identify individuals at increased risk for cardiovascular events. However, the independent role that elevated triglyceride levels play in cardiovascular risk has been more difficult to establish and controversial," he said.

This study suggests a modest independent association between triglycerides and coronary heart disease, Fonarow said.

"Despite these findings it still remains to be demonstrated whether lowering triglyceride levels in patients with -- or at risk for -- cardiovascular disease will in and of itself reduce the risk of cardiovascular events and if so by how much," he said.

Another expert, Dr. Byron Lee, an assistant professor of cardiology at the University of California, San Francisco, suggested the study could alter the guidelines for heart prevention. "Traditionally, clinicians have focused only on getting our patients' LDL down and our HDL up because we thought that these were the major players in heart disease," he said.

"However, this study indicates that we need to now worry about high triglyceride levels as well," he added.

More information

For more information on heart disease, visit the American Heart Association.



SOURCES: Nadeem Sarwar, Ph.D., lecturer in cardiovascular epidemiology, University of Cambridge, England; Gregg C. Fonarow, M.D., professor, medicine, and director, Ahmanson-UCLA Cardiomyopathy Center, University of California, Los Angeles; Byron Lee, M.D., assistant professor, cardiology, University of California, San Francisco; May 8, 2010, The Lancet


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Scientists ID a protein that splices and dices genes
2. Genes May Influence Preterm Births
3. New Research Shows Genes of Pregnant Women and Their Fetuses Can Increase the Risk of Preterm Labor
4. Genes of pregnant women and their fetuses can increase the risk of preterm labor
5. NIH scientists identify maternal and fetal genes that increase preterm birth risk
6. Very Obese People May Be Missing Genes
7. Scientists map out regulatory regions of genome, hot spots for diabetes genes
8. Mutating Genes May Lead to Premature Births
9. ThermoGenesis Corp. Names Healthcare Industry Executive Craig Moore to Board of Directors
10. Genes, Diet Offer New Clues to Parkinsons Disease
11. Discovery Links Genes to Pancreatic Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... Beach, CA (PRWEB) , ... June 25, 2016 , ... ... UCLA with Magna Cum Laude and his M.D from the David Geffen School of ... Diego and returned to Los Angeles to complete his fellowship in hematology/oncology at the ...
(Date:6/25/2016)... Montreal, Canada (PRWEB) , ... June 25, 2016 , ... ... the pursuit of success. In terms of the latter, setting the bar too high ... low, risk more than just slow progress toward their goal. , Research from ...
(Date:6/24/2016)... ... ... June 19, 2016 is World Sickle Cell Observance Day. In an effort to ... treatments, Serenity Recovery Center of Marne, Michigan, has issued a pain management ... (SCD) is a disorder of the red blood cells, which can cause episodes of ...
(Date:6/24/2016)... MIAMI, Fla. (PRWEB) , ... June 24, 2016 , ... ... Florida Trend magazine’s 2016 Legal Elite. The attorneys chosen by their peers for this ... of Florida. , Seven Greenberg Traurig Shareholders received special honors as members of this ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and ... that call for a minimum wage raise to $12 an hour by 2020 and then ... will restore the lost value of the minimum wage, assure the wage floor does not ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016  Guerbet announced today that ... Supplier Horizon Award . One of ... was recognized for its support of Premier members through ... clinical excellence, and commitment to lower costs. ... this recognition of our outstanding customer service from Premier," ...
(Date:6/23/2016)... 23, 2016 Research and Markets ... Volumes: Global Analysis (United States, China, Japan, Brazil, United ... to their offering. ... healthcare business planners, provides surgical procedure volume data in ... with an in-depth analysis of growth drivers and inhibitors, ...
(Date:6/23/2016)... The Biotechnology industry might still ... great opportunities to investors. Stock-Callers.com assesses the recent performances ... XON ), Vertex Pharmaceuticals Inc. (NASDAQ: ... ARNA ), and Regeneron Pharmaceuticals Inc. (NASDAQ: ... your complimentary trade alerts at: http://stock-callers.com/registration ...
Breaking Medicine Technology: