Navigation Links
Genes Tie Blood Fat to Heart Disease
Date:5/6/2010

Mutation can increase risk by up to 40 percent, researchers say

THURSDAY, May 6 (HealthDay News) -- Scientists have long debated the role triglyceride levels might play in heart disease, and finally they have genetic evidence linking high concentrations of the blood fat to an increased risk of heart trouble.

Until now, cholesterol levels were the key targets of heart disease prevention efforts, but experts say a new report in the May 8 issue of The Lancet may revise that thinking.

Triglycerides, a major source of human energy, are produced by the liver or derived from foods. "Despite several decades of research, it has remained uncertain whether raised levels of triglyceride can cause heart disease," said lead researcher Nadeem Sarwar, a lecturer in cardiovascular epidemiology at the University of Cambridge in England.

"We found that people with a genetically programmed tendency for higher triglyceride levels also had a greater risk of heart disease," Sarwar said. "This suggests that triglyceride pathways may be involved in the development of heart disease."

To explore a genetic link between triglycerides and heart disease, Sarwar's team collected data on 302,430 people who participated in 101 studies. "We employed novel genetic approaches -- so-called 'Mendelian randomization analysis,'" he said.

Specifically, the researchers looked at mutations in the apolipoprotein A5 gene, a known determinant of triglyceride concentrations. They found that for every copy of the variant, there was a 16 percent increase in triglyceride concentrations, so two copies increased triglyceride levels 32 percent.

People with two such variants had a 40 percent increased risk of developing heart disease, the researchers calculated.

Although these genetic findings indicate a causative role for triglyceride pathways in the development of heart disease, they do not replace the need for large randomized clinical trials of medications that lower blood triglyceride levels, Sarwar said.

Such trials should help establish whether reducing triglyceride concentration can reduce the risk of heart disease, he said. "There are several medications currently available or under development that can influence blood triglyceride levels," he noted.

Drug maker Novartis, the British Heart Foundation and the UK Medical Research Council funded the study.

Dr. Gregg C. Fonarow, a professor of cardiovascular medicine and director of the Ahmanson-UCLA Cardiomyopathy Center at the University of California, Los Angeles, also said more research is needed.

"Elevated LDL cholesterol has been definitively established as a major modifiable cardiovascular risk factor," he said. "There is also strong evidence that low levels of HDL identify individuals at increased risk for cardiovascular events. However, the independent role that elevated triglyceride levels play in cardiovascular risk has been more difficult to establish and controversial," he said.

This study suggests a modest independent association between triglycerides and coronary heart disease, Fonarow said.

"Despite these findings it still remains to be demonstrated whether lowering triglyceride levels in patients with -- or at risk for -- cardiovascular disease will in and of itself reduce the risk of cardiovascular events and if so by how much," he said.

Another expert, Dr. Byron Lee, an assistant professor of cardiology at the University of California, San Francisco, suggested the study could alter the guidelines for heart prevention. "Traditionally, clinicians have focused only on getting our patients' LDL down and our HDL up because we thought that these were the major players in heart disease," he said.

"However, this study indicates that we need to now worry about high triglyceride levels as well," he added.

More information

For more information on heart disease, visit the American Heart Association.



SOURCES: Nadeem Sarwar, Ph.D., lecturer in cardiovascular epidemiology, University of Cambridge, England; Gregg C. Fonarow, M.D., professor, medicine, and director, Ahmanson-UCLA Cardiomyopathy Center, University of California, Los Angeles; Byron Lee, M.D., assistant professor, cardiology, University of California, San Francisco; May 8, 2010, The Lancet


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Scientists ID a protein that splices and dices genes
2. Genes May Influence Preterm Births
3. New Research Shows Genes of Pregnant Women and Their Fetuses Can Increase the Risk of Preterm Labor
4. Genes of pregnant women and their fetuses can increase the risk of preterm labor
5. NIH scientists identify maternal and fetal genes that increase preterm birth risk
6. Very Obese People May Be Missing Genes
7. Scientists map out regulatory regions of genome, hot spots for diabetes genes
8. Mutating Genes May Lead to Premature Births
9. ThermoGenesis Corp. Names Healthcare Industry Executive Craig Moore to Board of Directors
10. Genes, Diet Offer New Clues to Parkinsons Disease
11. Discovery Links Genes to Pancreatic Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... , ... First Choice Emergency Room , the largest network of independent ... Director of its new Mesquite-Samuell Farm facility. , “We are pleased to announce ... Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , ...
(Date:6/25/2016)... City, Oklahoma (PRWEB) , ... June 25, 2016 ... ... helping both athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic ... the Oklahoma City area —Johnson is one of the first doctors to perform ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits of ... of the latter, setting the bar too high can result in disappointment, perhaps even ... progress toward their goal. , Research from PsychTests.com reveals that behind ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events may suffer ... unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. To avoid ... healthy coping following a traumatic event. , Trauma sufferers tend to feel a range ...
(Date:6/24/2016)... ... , ... Marcy was in a crisis. Her son James, eight, was out of control. Prone ... physically. , “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If ... at my other children and say he was going to kill them. If we ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... DUBLIN , June 24, 2016 ... "The World Market for Companion Diagnostic Tests" report to ... World Market for Companion Diagnostics The World ... diagnostic and personalized medicine diagnostics. Market analysis in the report ... Diagnostics Test Market (In Vitro Diagnostic Kits) by Region (N. ...
(Date:6/23/2016)... 2016  MedSource announced today that it has ... solution of choice.  This latest decision demonstrates MedSource,s ... their clients by offering a state-of-the-art electronic data ... nowEDC as the EDC platform of choice in ... "nowEDC has long been a preferred EDC platform ...
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 Roche ... received 510(k) clearance for its Elecsys BRAHMS PCT (procalcitonin) ... severe sepsis or septic shock. With this clearance, Roche ... provide a fully integrated solution for sepsis risk assessment ... associated with bacterial infection and PCT levels in blood ...
Breaking Medicine Technology: